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High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner

Correa, Yubexi ; Del Giudice, Rita LU ; Waldie, Sarah ; Thépaut, Michel ; Micciula, Samantha ; Gerelli, Yuri ; Moulin, Martine ; Delaunay, Clara ; Fieschi, Franck and Pichler, Harald , et al. (2023) In Journal of Colloid and Interface Science 645. p.627-638
Abstract

There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile.... (More)

There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cholesterol efflux capacity, COVID-19, Deuterated cholesterol, HDL, Lipid metabolism, Lipids, Neutron reflection, SARS-CoV-2 spike protein
in
Journal of Colloid and Interface Science
volume
645
pages
12 pages
publisher
Elsevier
external identifiers
  • pmid:37167912
  • scopus:85158888783
ISSN
0021-9797
DOI
10.1016/j.jcis.2023.04.137
language
English
LU publication?
yes
id
880f0deb-ec07-44b4-b530-b2025e9e27fa
date added to LUP
2023-08-10 10:16:46
date last changed
2024-04-20 00:15:51
@article{880f0deb-ec07-44b4-b530-b2025e9e27fa,
  abstract     = {{<p>There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and the ability of HDL to efflux cholesterol from macrophages, we confirm these observations and further identify the preference of the S protein for specific lipids and the consequent effects on HDL function on lipid exchange ability. Moreover, the effect of the S protein on HDL function differs depending on the individuals lipid serum profile. Contrasting trends were observed for individuals presenting low triglycerides/high cholesterol serum levels (LTHC) compared to high triglycerides/high cholesterol (HTHC) or low triglycerides/low cholesterol serum levels (LTLC). Collectively, these results suggest that the S protein interacts with the HDL particle and, depending on the lipid profile of the infected individual, it impairs its function during COVID-19 infection, causing an imbalance in lipid metabolism.</p>}},
  author       = {{Correa, Yubexi and Del Giudice, Rita and Waldie, Sarah and Thépaut, Michel and Micciula, Samantha and Gerelli, Yuri and Moulin, Martine and Delaunay, Clara and Fieschi, Franck and Pichler, Harald and Haertlein, Michael and Forsyth, V. Trevor and Le Brun, Anton and Moir, Michael and Russell, Robert A. and Darwish, Tamim and Brinck, Jonas and Wodaje, Tigist and Jansen, Martin and Martín, César and Roosen - Runge, Felix and Cárdenas, Marité}},
  issn         = {{0021-9797}},
  keywords     = {{Cholesterol efflux capacity; COVID-19; Deuterated cholesterol; HDL; Lipid metabolism; Lipids; Neutron reflection; SARS-CoV-2 spike protein}},
  language     = {{eng}},
  pages        = {{627--638}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Colloid and Interface Science}},
  title        = {{High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner}},
  url          = {{http://dx.doi.org/10.1016/j.jcis.2023.04.137}},
  doi          = {{10.1016/j.jcis.2023.04.137}},
  volume       = {{645}},
  year         = {{2023}},
}