Advanced

Familial risks for epilepsy among siblings based on hospitalizations in Sweden

Hemminki, Kari LU ; Li, Xinjun LU ; Johansson, Sven-Erik LU ; Sundquist, Kristina LU and Sundquist, Jan LU (2006) In Neuroepidemiology 27(2). p.67-73
Abstract

PURPOSE: Epilepsy is a common disabling condition, with high heritability according to twin studies. Characterization of familial risks for common subtypes of epilepsy will advance the search for the heritable causes of these conditions and their underlying mechanisms. We aim at defining familial risks for siblings to be hospitalized because of epilepsy.

METHODS: A nationwide ad hoc epilepsy database was constructed by linking the Multigeneration Register on 0- to 69-year-old siblings to the Hospital Discharge Register for data on epilepsies covering the years 1987-2001. Standardized risk ratios (SIRs) were calculated for affected sibling pairs by comparing them to those whose siblings had no epilepsy.

RESULTS: Among a total... (More)

PURPOSE: Epilepsy is a common disabling condition, with high heritability according to twin studies. Characterization of familial risks for common subtypes of epilepsy will advance the search for the heritable causes of these conditions and their underlying mechanisms. We aim at defining familial risks for siblings to be hospitalized because of epilepsy.

METHODS: A nationwide ad hoc epilepsy database was constructed by linking the Multigeneration Register on 0- to 69-year-old siblings to the Hospital Discharge Register for data on epilepsies covering the years 1987-2001. Standardized risk ratios (SIRs) were calculated for affected sibling pairs by comparing them to those whose siblings had no epilepsy.

RESULTS: Among a total of 26,799 hospitalized cases, 598 affected siblings were identified with a familial SIR of 2.35; the SIR was highest at ages 0-4 years (6.82). Infantile spasms showed the highest risk for any subtype (10.45), when a co-sibling was diagnosed with any epilepsy. When both siblings were diagnosed with a concordant (same) subtype of epilepsy, the SIRs were high, i.e. 8.43 for generalized idiopathic epilepsy, 2.56 for partial epilepsy, 24.72 for status epilepticus and 24.39 for other epilepsies. Generalized idiopathic epilepsy was also associated with grand mal (4.06) and other epilepsies (7.61). The numbers of cases were small but concordant diagnoses always showing higher SIRs compared with discordant diagnoses.

CONCLUSIONS: Within the limits of the present sample size, our results suggest high familial aggregation for certain subtypes of epilepsy for which distinct genetic mechanisms may underlie.

(Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent, Adult, Age Factors, Aged, Algorithms, Child, Child, Preschool, Databases, Factual, Epilepsy/epidemiology, Ethics, Female, Hospitalization/statistics & numerical data, Humans, Infant, Male, Middle Aged, Registries, Risk, Sex Factors, Siblings, Socioeconomic Factors, Sweden/epidemiology, Treatment Outcome
in
Neuroepidemiology
volume
27
issue
2
pages
7 pages
publisher
Karger
external identifiers
  • scopus:33748641516
ISSN
0251-5350
DOI
10.1159/000094976
language
English
LU publication?
no
id
8818cf79-e58d-41d2-83ff-b63983bb63dc
date added to LUP
2019-01-30 11:11:47
date last changed
2019-06-19 04:08:14
@article{8818cf79-e58d-41d2-83ff-b63983bb63dc,
  abstract     = {<p>PURPOSE: Epilepsy is a common disabling condition, with high heritability according to twin studies. Characterization of familial risks for common subtypes of epilepsy will advance the search for the heritable causes of these conditions and their underlying mechanisms. We aim at defining familial risks for siblings to be hospitalized because of epilepsy.</p><p>METHODS: A nationwide ad hoc epilepsy database was constructed by linking the Multigeneration Register on 0- to 69-year-old siblings to the Hospital Discharge Register for data on epilepsies covering the years 1987-2001. Standardized risk ratios (SIRs) were calculated for affected sibling pairs by comparing them to those whose siblings had no epilepsy.</p><p>RESULTS: Among a total of 26,799 hospitalized cases, 598 affected siblings were identified with a familial SIR of 2.35; the SIR was highest at ages 0-4 years (6.82). Infantile spasms showed the highest risk for any subtype (10.45), when a co-sibling was diagnosed with any epilepsy. When both siblings were diagnosed with a concordant (same) subtype of epilepsy, the SIRs were high, i.e. 8.43 for generalized idiopathic epilepsy, 2.56 for partial epilepsy, 24.72 for status epilepticus and 24.39 for other epilepsies. Generalized idiopathic epilepsy was also associated with grand mal (4.06) and other epilepsies (7.61). The numbers of cases were small but concordant diagnoses always showing higher SIRs compared with discordant diagnoses.</p><p>CONCLUSIONS: Within the limits of the present sample size, our results suggest high familial aggregation for certain subtypes of epilepsy for which distinct genetic mechanisms may underlie.</p>},
  author       = {Hemminki, Kari and Li, Xinjun and Johansson, Sven-Erik and Sundquist, Kristina and Sundquist, Jan},
  issn         = {0251-5350},
  keyword      = {Adolescent,Adult,Age Factors,Aged,Algorithms,Child,Child, Preschool,Databases, Factual,Epilepsy/epidemiology,Ethics,Female,Hospitalization/statistics & numerical data,Humans,Infant,Male,Middle Aged,Registries,Risk,Sex Factors,Siblings,Socioeconomic Factors,Sweden/epidemiology,Treatment Outcome},
  language     = {eng},
  number       = {2},
  pages        = {67--73},
  publisher    = {Karger},
  series       = {Neuroepidemiology},
  title        = {Familial risks for epilepsy among siblings based on hospitalizations in Sweden},
  url          = {http://dx.doi.org/10.1159/000094976},
  volume       = {27},
  year         = {2006},
}