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Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.

Valentino, L A; Pipe, S W; Collins, P W; Blanchette, V S; Berntorp, Erik LU ; Fischer, K; Ewenstein, B M; Oh, M and Spotts, G (2016) In Haemophilia 22(4). p.20-514
Abstract
We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Haemophilia
volume
22
issue
4
pages
20 - 514
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:26930418
  • scopus:84979085792
  • wos:000387387000029
ISSN
1351-8216
DOI
10.1111/hae.12905
language
English
LU publication?
yes
id
8246190c-7195-4c94-9724-6a9037613b21 (old id 8856697)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26930418?dopt=Abstract
date added to LUP
2016-03-15 10:39:29
date last changed
2017-11-19 04:16:37
@article{8246190c-7195-4c94-9724-6a9037613b21,
  abstract     = {We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.},
  author       = {Valentino, L A and Pipe, S W and Collins, P W and Blanchette, V S and Berntorp, Erik and Fischer, K and Ewenstein, B M and Oh, M and Spotts, G},
  issn         = {1351-8216},
  language     = {eng},
  month        = {03},
  number       = {4},
  pages        = {20--514},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.},
  url          = {http://dx.doi.org/10.1111/hae.12905},
  volume       = {22},
  year         = {2016},
}