Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.
(2016) In Haemophilia 22(4). p.20-514- Abstract
- We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8856697
- author
- Valentino, L A ; Pipe, S W ; Collins, P W ; Blanchette, V S ; Berntorp, Erik LU ; Fischer, K ; Ewenstein, B M ; Oh, M and Spotts, G
- organization
- publishing date
- 2016-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Haemophilia
- volume
- 22
- issue
- 4
- pages
- 20 - 514
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:26930418
- pmid:26930418
- scopus:84979085792
- wos:000387387000029
- ISSN
- 1351-8216
- DOI
- 10.1111/hae.12905
- language
- English
- LU publication?
- yes
- id
- 8246190c-7195-4c94-9724-6a9037613b21 (old id 8856697)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26930418?dopt=Abstract
- date added to LUP
- 2016-04-04 07:13:43
- date last changed
- 2022-09-06 20:23:01
@article{8246190c-7195-4c94-9724-6a9037613b21, abstract = {{We previously showed that pharmacokinetic-guided prophylaxis (PKP) allows the dosing interval to be extended while maintaining a specific trough level. However, the associations of peak factor VIII (FVIII) levels and area under the curve (AUC) with breakthrough bleeding have not been investigated.}}, author = {{Valentino, L A and Pipe, S W and Collins, P W and Blanchette, V S and Berntorp, Erik and Fischer, K and Ewenstein, B M and Oh, M and Spotts, G}}, issn = {{1351-8216}}, language = {{eng}}, month = {{03}}, number = {{4}}, pages = {{20--514}}, publisher = {{Wiley-Blackwell}}, series = {{Haemophilia}}, title = {{Association of peak factor VIII levels and area under the curve with bleeding in patients with haemophilia A on every third day pharmacokinetic-guided prophylaxis.}}, url = {{http://dx.doi.org/10.1111/hae.12905}}, doi = {{10.1111/hae.12905}}, volume = {{22}}, year = {{2016}}, }