Cytokines and Janus kinase/signal transducer and activator of transcription signaling in prostate cancer : overview and therapeutic opportunities
(2020) In Current Opinion in Endocrine and Metabolic Research 10. p.36-42- Abstract
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway was originally identified as a key cellular mechanism mediating the action of cytokines, interferons, and growth factors for the control of gene expression. Extracellular signals mediated by cytokines are thus transduced through this pathway into transcriptional programs that regulate cell growth, differentiation, proliferation, invasion, survival, and inflammation. In prostate cancer, an aberrant or persistent activation of the JAK/STAT signaling is related to tumor growth and disease progression, making this pathway an ideal therapeutic target. Here, we review the most recent literature on this topic, and we summarize the latest advances and future... (More)
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway was originally identified as a key cellular mechanism mediating the action of cytokines, interferons, and growth factors for the control of gene expression. Extracellular signals mediated by cytokines are thus transduced through this pathway into transcriptional programs that regulate cell growth, differentiation, proliferation, invasion, survival, and inflammation. In prostate cancer, an aberrant or persistent activation of the JAK/STAT signaling is related to tumor growth and disease progression, making this pathway an ideal therapeutic target. Here, we review the most recent literature on this topic, and we summarize the latest advances and future challenges in therapeutically targeting the JAK/STAT pathway in prostate cancer.
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- author
- Canesin, Giacomo LU ; Krzyzanowska, Agnieszka LU ; Hellsten, Rebecka LU and Bjartell, Anders LU
- organization
- publishing date
- 2020-02-24
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Castration-resistant prostate cancer, Cytokines, IL-6, JAK/STAT pathway, Myeloid-derived suppressor cells, Prostate cancer, STAT3
- in
- Current Opinion in Endocrine and Metabolic Research
- volume
- 10
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85081744437
- ISSN
- 2451-9650
- DOI
- 10.1016/j.coemr.2020.02.004
- language
- English
- LU publication?
- yes
- id
- 8872e90e-1185-4a90-9bc8-8bb682bef3cc
- date added to LUP
- 2020-04-07 13:40:17
- date last changed
- 2022-05-04 17:00:26
@article{8872e90e-1185-4a90-9bc8-8bb682bef3cc, abstract = {{<p>The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway was originally identified as a key cellular mechanism mediating the action of cytokines, interferons, and growth factors for the control of gene expression. Extracellular signals mediated by cytokines are thus transduced through this pathway into transcriptional programs that regulate cell growth, differentiation, proliferation, invasion, survival, and inflammation. In prostate cancer, an aberrant or persistent activation of the JAK/STAT signaling is related to tumor growth and disease progression, making this pathway an ideal therapeutic target. Here, we review the most recent literature on this topic, and we summarize the latest advances and future challenges in therapeutically targeting the JAK/STAT pathway in prostate cancer.</p>}}, author = {{Canesin, Giacomo and Krzyzanowska, Agnieszka and Hellsten, Rebecka and Bjartell, Anders}}, issn = {{2451-9650}}, keywords = {{Castration-resistant prostate cancer; Cytokines; IL-6; JAK/STAT pathway; Myeloid-derived suppressor cells; Prostate cancer; STAT3}}, language = {{eng}}, month = {{02}}, pages = {{36--42}}, publisher = {{Elsevier}}, series = {{Current Opinion in Endocrine and Metabolic Research}}, title = {{Cytokines and Janus kinase/signal transducer and activator of transcription signaling in prostate cancer : overview and therapeutic opportunities}}, url = {{http://dx.doi.org/10.1016/j.coemr.2020.02.004}}, doi = {{10.1016/j.coemr.2020.02.004}}, volume = {{10}}, year = {{2020}}, }