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Three-month neoadjuvant hormonal therapy before radical prostatectomy: a 7-year follow-up of a randomized controlled trial

Aus, G; Abrahamsson, Per-Anders LU ; Ahlgren, Göran LU ; Hugosson, J; Lundberg, S; Schain, M; Schelin, S and Pedersen, K (2002) In BJU International1999-01-01+01:00 90(6). p.561-566
Abstract
Objective To describe the outcome, assessed as the level of prostate specific antigen (PSA), of a mature (more than half the events recorded) prospective randomized study with a median follow-up of 82 months of neoadjuvant hormonal therapy before radical prostatectomy, as this has been suggested to decrease the rate of positive surgical margins (i.e. provide greater potential to completely excise the tumour). Patient and methods From December 1991 to March 1994, 126 patients with clinically localized prostate cancer were randomized between direct radical prostatectomy or a 3-month course of a gonadotrophin-releasing hormone analogue before surgery. The patients were followed by PSA determinations and a value of > 0.5 ng/mL used to... (More)
Objective To describe the outcome, assessed as the level of prostate specific antigen (PSA), of a mature (more than half the events recorded) prospective randomized study with a median follow-up of 82 months of neoadjuvant hormonal therapy before radical prostatectomy, as this has been suggested to decrease the rate of positive surgical margins (i.e. provide greater potential to completely excise the tumour). Patient and methods From December 1991 to March 1994, 126 patients with clinically localized prostate cancer were randomized between direct radical prostatectomy or a 3-month course of a gonadotrophin-releasing hormone analogue before surgery. The patients were followed by PSA determinations and a value of > 0.5 ng/mL used to define progression. Results The incidence of positive surgical margins decreased from 45.5% to 23.6% (P = 0.016) with hormone treatment. Despite this there was no difference in PSA progression-free survival at the last follow-up; it was 51.5% for those undergoing radical prostatectomy only and 49.8% for those who received hormonal pretreatment (P = 0.588). Conclusions Three months of neoadjuvant hormonal therapy before radical prostatectomy offers no benefit to the patient and cannot be recommended for routine clinical use. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prostate cancer, treatment, hormonal therapy, radical prostatectomy, randomized trial, follow-up
in
BJU International1999-01-01+01:00
volume
90
issue
6
pages
561 - 566
publisher
Blackwell Science Ltd
external identifiers
  • pmid:12230618
  • wos:000178007600013
  • scopus:0036381078
ISSN
1464-4096
DOI
10.1046/j.1464-410X.2002.02982.x
language
English
LU publication?
yes
id
b7804a9f-c00c-47f2-a951-a51d9a79ef53 (old id 892644)
date added to LUP
2008-01-15 16:58:47
date last changed
2017-06-11 03:30:09
@article{b7804a9f-c00c-47f2-a951-a51d9a79ef53,
  abstract     = {Objective To describe the outcome, assessed as the level of prostate specific antigen (PSA), of a mature (more than half the events recorded) prospective randomized study with a median follow-up of 82 months of neoadjuvant hormonal therapy before radical prostatectomy, as this has been suggested to decrease the rate of positive surgical margins (i.e. provide greater potential to completely excise the tumour). Patient and methods From December 1991 to March 1994, 126 patients with clinically localized prostate cancer were randomized between direct radical prostatectomy or a 3-month course of a gonadotrophin-releasing hormone analogue before surgery. The patients were followed by PSA determinations and a value of > 0.5 ng/mL used to define progression. Results The incidence of positive surgical margins decreased from 45.5% to 23.6% (P = 0.016) with hormone treatment. Despite this there was no difference in PSA progression-free survival at the last follow-up; it was 51.5% for those undergoing radical prostatectomy only and 49.8% for those who received hormonal pretreatment (P = 0.588). Conclusions Three months of neoadjuvant hormonal therapy before radical prostatectomy offers no benefit to the patient and cannot be recommended for routine clinical use.},
  author       = {Aus, G and Abrahamsson, Per-Anders and Ahlgren, Göran and Hugosson, J and Lundberg, S and Schain, M and Schelin, S and Pedersen, K},
  issn         = {1464-4096},
  keyword      = {prostate cancer,treatment,hormonal therapy,radical prostatectomy,randomized trial,follow-up},
  language     = {eng},
  number       = {6},
  pages        = {561--566},
  publisher    = {Blackwell Science Ltd},
  series       = {BJU International1999-01-01+01:00},
  title        = {Three-month neoadjuvant hormonal therapy before radical prostatectomy: a 7-year follow-up of a randomized controlled trial},
  url          = {http://dx.doi.org/10.1046/j.1464-410X.2002.02982.x},
  volume       = {90},
  year         = {2002},
}