A Population-Based Study of Unfavorable Prognostic Factors Associated With Pyogenic Liver Abscess
Bläckberg, Anna LU ; Jönsson, Astrid ; Svensson, Emma ; Sunnerhagen, Torgny LU
; Kiasat, Ali
and Ljungquist, Oskar
LU
(2023)
In Open Forum Infectious Diseases
10(8).
- Abstract
- Background
Pyogenic liver abscess (PLA) is a rare entity that is associated with substantial mortality and morbidity. Our objective was to investigate variables associated with mortality and subsequent PLA in patients diagnosed with PLA in southern Sweden.
Methods
We conducted a population-based observational study comprising all episodes of PLA that occurred between 2011 and 2020 in the county of Skåne, southern Sweden. The primary outcome was defined as all-cause 90-day mortality and the secondary outcome was defined as the occurrence of a subsequent PLA.
Results
A total of 452 episodes of PLA occurred in 360 patients during the study period. The 90-day mortality rate was 16% (n = 58) and the subsequent PLA... (More) - Background
Pyogenic liver abscess (PLA) is a rare entity that is associated with substantial mortality and morbidity. Our objective was to investigate variables associated with mortality and subsequent PLA in patients diagnosed with PLA in southern Sweden.
Methods
We conducted a population-based observational study comprising all episodes of PLA that occurred between 2011 and 2020 in the county of Skåne, southern Sweden. The primary outcome was defined as all-cause 90-day mortality and the secondary outcome was defined as the occurrence of a subsequent PLA.
Results
A total of 452 episodes of PLA occurred in 360 patients during the study period. The 90-day mortality rate was 16% (n = 58) and the subsequent PLA rate was 20% (n = 92). In a multivariable logistic regression model, female sex (odds ratio [OR], 2.0 [95% confidence interval {CI}, 1.1–3.9]), malignancy (OR, 3.7 [95% CI, 1.9–7.1]), liver failure (OR, 6.3 [95% CI, 2.7–14.5]), and polymicrobial findings (OR, 3.8 [95% CI, 2.2–6.9]) were associated with death within 90 days (P < .05). Male sex (OR, 2.1 [95% CI, 1.2–3.6]), malignancy (OR, 2.1 [95% CI, 1.3–3.6]), age (64–74 years: OR, 2.5 [95% CI, 1.3–4.8]), and chronic liver disease (OR, 3.0 [95% CI, 1.4–6.5]) were associated with the risk of subsequent PLA (P ≤ .01).
Conclusions
Identifying different clinical variables associated with an unfavorable outcome may improve the management and treatment of patients with PLA and thus prevent the risk of death and subsequent PLA. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/895c287c-e8c5-4117-9c3c-611a69397a3f
- author
- Bläckberg, Anna
LU
; Jönsson, Astrid
; Svensson, Emma
; Sunnerhagen, Torgny
LU
; Kiasat, Ali
and Ljungquist, Oskar
LU
- organization
- publishing date
- 2023-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Open Forum Infectious Diseases
- volume
- 10
- issue
- 8
- article number
- ofad352
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85168509415
- pmid:37547858
- ISSN
- 2328-8957
- DOI
- 10.1093/ofid/ofad352
- language
- English
- LU publication?
- yes
- id
- 895c287c-e8c5-4117-9c3c-611a69397a3f
- alternative location
- https://academic.oup.com/ofid/article/doi/10.1093/ofid/ofad352/7222602
- date added to LUP
- 2023-08-06 11:30:42
- date last changed
- 2024-02-20 00:36:16
@article{895c287c-e8c5-4117-9c3c-611a69397a3f,
abstract = {{Background<br/>Pyogenic liver abscess (PLA) is a rare entity that is associated with substantial mortality and morbidity. Our objective was to investigate variables associated with mortality and subsequent PLA in patients diagnosed with PLA in southern Sweden.<br/><br/>Methods<br/>We conducted a population-based observational study comprising all episodes of PLA that occurred between 2011 and 2020 in the county of Skåne, southern Sweden. The primary outcome was defined as all-cause 90-day mortality and the secondary outcome was defined as the occurrence of a subsequent PLA.<br/><br/>Results<br/>A total of 452 episodes of PLA occurred in 360 patients during the study period. The 90-day mortality rate was 16% (n = 58) and the subsequent PLA rate was 20% (n = 92). In a multivariable logistic regression model, female sex (odds ratio [OR], 2.0 [95% confidence interval {CI}, 1.1–3.9]), malignancy (OR, 3.7 [95% CI, 1.9–7.1]), liver failure (OR, 6.3 [95% CI, 2.7–14.5]), and polymicrobial findings (OR, 3.8 [95% CI, 2.2–6.9]) were associated with death within 90 days (P < .05). Male sex (OR, 2.1 [95% CI, 1.2–3.6]), malignancy (OR, 2.1 [95% CI, 1.3–3.6]), age (64–74 years: OR, 2.5 [95% CI, 1.3–4.8]), and chronic liver disease (OR, 3.0 [95% CI, 1.4–6.5]) were associated with the risk of subsequent PLA (P ≤ .01).<br/><br/>Conclusions<br/>Identifying different clinical variables associated with an unfavorable outcome may improve the management and treatment of patients with PLA and thus prevent the risk of death and subsequent PLA.}},
author = {{Bläckberg, Anna and Jönsson, Astrid and Svensson, Emma and Sunnerhagen, Torgny and Kiasat, Ali and Ljungquist, Oskar}},
issn = {{2328-8957}},
language = {{eng}},
month = {{08}},
number = {{8}},
publisher = {{Oxford University Press}},
series = {{Open Forum Infectious Diseases}},
title = {{A Population-Based Study of Unfavorable Prognostic Factors Associated With Pyogenic Liver Abscess}},
url = {{https://lup.lub.lu.se/search/files/154183585/ofad352.pdf}},
doi = {{10.1093/ofid/ofad352}},
volume = {{10}},
year = {{2023}},
}