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Protein Z and protein Z-dependent protease inhibitor - Determinants of levels and risk of venous thrombosis

Al-Shanqeeti, A; Vlieg, AV; Berntorp, Erik LU ; Rosendaal, FR and Broze, GJ (2005) In Thrombosis and Haemostasis 93(3). p.411-413
Abstract
To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
thrombophilia, coagulation inhibitors, clinical/epidemiological studies
in
Thrombosis and Haemostasis
volume
93
issue
3
pages
411 - 413
publisher
F K Schattauer Verlag Gmbh
external identifiers
  • wos:000227808200004
  • scopus:15344345528
ISSN
0340-6245
DOI
10.1160/TH04-11-0715
language
English
LU publication?
yes
id
19642b49-799a-4b7d-839f-a9e8fca6aeab (old id 896984)
alternative location
https://www.openaccess.leidenuniv.nl/dspace/bitstream/1887/5054/1/2_303_440.pdf
date added to LUP
2008-01-11 10:01:39
date last changed
2017-01-15 04:20:45
@article{19642b49-799a-4b7d-839f-a9e8fca6aeab,
  abstract     = {To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.},
  author       = {Al-Shanqeeti, A and Vlieg, AV and Berntorp, Erik and Rosendaal, FR and Broze, GJ},
  issn         = {0340-6245},
  keyword      = {thrombophilia,coagulation inhibitors,clinical/epidemiological studies},
  language     = {eng},
  number       = {3},
  pages        = {411--413},
  publisher    = {F K Schattauer Verlag Gmbh},
  series       = {Thrombosis and Haemostasis},
  title        = {Protein Z and protein Z-dependent protease inhibitor - Determinants of levels and risk of venous thrombosis},
  url          = {http://dx.doi.org/10.1160/TH04-11-0715},
  volume       = {93},
  year         = {2005},
}