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Single nucleotide polymorphisms in the human gene for osteoprotegerin are not related to bone mineral density or fracture in elderly women

Brandstrom, H; Gerdhem, Paul LU ; Stiger, F; Obrant, Karl LU ; Melhus, H; Ljunggren, O; Kindmark, A and Åkesson, Kristina LU (2004) In Calcified Tissue International 74(1). p.18-24
Abstract
Osteoprotegerin (OPG), a secreted member of the tumor necrosis factor receptor family, is a potent inhibitor of osteoclast activation and differentiation. In animal models OPG prevents bone loss, and in humans bone resorption can be reduced by injections of OPG. OPG may also play a role in cardiovascular disease since mice lacking the OPG gene display arterial calcification. In a screening effort of the OPG gene, we recently discovered a single nucleotide polymorphism in the promoter region of OPG (T950C), and reported an association with vascular morphology and function in 59 healthy individuals. Due to the pronounced effect of OPG on bone turnover, the present study was conducted to investigate whether OPG polymorphisms are also... (More)
Osteoprotegerin (OPG), a secreted member of the tumor necrosis factor receptor family, is a potent inhibitor of osteoclast activation and differentiation. In animal models OPG prevents bone loss, and in humans bone resorption can be reduced by injections of OPG. OPG may also play a role in cardiovascular disease since mice lacking the OPG gene display arterial calcification. In a screening effort of the OPG gene, we recently discovered a single nucleotide polymorphism in the promoter region of OPG (T950C), and reported an association with vascular morphology and function in 59 healthy individuals. Due to the pronounced effect of OPG on bone turnover, the present study was conducted to investigate whether OPG polymorphisms are also associated with bone mineral density or with fracture. The relationship between single nucleotide polymorphisms in the promoter region of OPG (T950C) and the first intron (C1217T), and bone mineral density, measured by DXA in the hip or spine or ultrasound of the heel, was investigated in the Malmo OPRA-study of 1044 women, all 75 years old. The possible relation to fracture incidence was also analyzed. Among the 858 and 864 individuals respectively, genotyped, no significant associations between the investigated single nucleotide polymorphisms and bone mineral density measurements (T950C P=0.50-0.64, C1217T P=0.51-1.00), quantitative ultrasound measurements of the calcaneus, or fractures (T950C P=0.61-0.66, C1217T P=0.14-0.33) were found. Thus, our results show that polymorphisms in the OPG gene, one of which has previously been found to be associated with cardiovascular morphology and function, are not associated with bone mineral density in elderly Swedish women. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
OPG, polymorphism, BMD, fractures, ultrasound
in
Calcified Tissue International
volume
74
issue
1
pages
18 - 24
publisher
Springer
external identifiers
  • wos:000188662700003
  • scopus:0842348791
ISSN
1432-0827
DOI
10.1007/s00223-002-2136-9
language
English
LU publication?
yes
id
1ff7e682-3fb7-46eb-ad7e-b340cd742927 (old id 899425)
date added to LUP
2008-01-10 13:07:22
date last changed
2017-05-28 04:24:47
@article{1ff7e682-3fb7-46eb-ad7e-b340cd742927,
  abstract     = {Osteoprotegerin (OPG), a secreted member of the tumor necrosis factor receptor family, is a potent inhibitor of osteoclast activation and differentiation. In animal models OPG prevents bone loss, and in humans bone resorption can be reduced by injections of OPG. OPG may also play a role in cardiovascular disease since mice lacking the OPG gene display arterial calcification. In a screening effort of the OPG gene, we recently discovered a single nucleotide polymorphism in the promoter region of OPG (T950C), and reported an association with vascular morphology and function in 59 healthy individuals. Due to the pronounced effect of OPG on bone turnover, the present study was conducted to investigate whether OPG polymorphisms are also associated with bone mineral density or with fracture. The relationship between single nucleotide polymorphisms in the promoter region of OPG (T950C) and the first intron (C1217T), and bone mineral density, measured by DXA in the hip or spine or ultrasound of the heel, was investigated in the Malmo OPRA-study of 1044 women, all 75 years old. The possible relation to fracture incidence was also analyzed. Among the 858 and 864 individuals respectively, genotyped, no significant associations between the investigated single nucleotide polymorphisms and bone mineral density measurements (T950C P=0.50-0.64, C1217T P=0.51-1.00), quantitative ultrasound measurements of the calcaneus, or fractures (T950C P=0.61-0.66, C1217T P=0.14-0.33) were found. Thus, our results show that polymorphisms in the OPG gene, one of which has previously been found to be associated with cardiovascular morphology and function, are not associated with bone mineral density in elderly Swedish women.},
  author       = {Brandstrom, H and Gerdhem, Paul and Stiger, F and Obrant, Karl and Melhus, H and Ljunggren, O and Kindmark, A and Åkesson, Kristina},
  issn         = {1432-0827},
  keyword      = {OPG,polymorphism,BMD,fractures,ultrasound},
  language     = {eng},
  number       = {1},
  pages        = {18--24},
  publisher    = {Springer},
  series       = {Calcified Tissue International},
  title        = {Single nucleotide polymorphisms in the human gene for osteoprotegerin are not related to bone mineral density or fracture in elderly women},
  url          = {http://dx.doi.org/10.1007/s00223-002-2136-9},
  volume       = {74},
  year         = {2004},
}