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Increased intestinal permeability in primary Sjögren's syndrome and multiple sclerosis

Sjöström, Bitte LU ; Bredberg, Anders LU ; Mandl, Thomas LU ; Alonso-Magdalena, Lucía LU ; Ohlsson, Bodil LU ; Lavasani, Shahram LU ; Nouri, Mehrnaz LU and Henriksson, Gunnel LU (2021) In Journal of Translational Autoimmunity 4.
Abstract

There is increasing evidence suggesting a role of intestinal dysfunction in a number of autoimmune diseases. Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with a documented increased level of intestinal inflammation, whereas multiple sclerosis (MS) is an organ-specific autoimmune disease known to exhibit increased intestinal permeability. In this study we determine to what extent intestinal inflammation, analysed by a faecal calprotectin ELISA, is accompanied by altered intestinal wall permeability, as measured by a lactulose and mannitol intestinal absorption assay. Intestinal permeability was increased in both pSS and MS patients, while faecal calprotectin was elevated in pSS but normal in MS. Our findings suggest... (More)

There is increasing evidence suggesting a role of intestinal dysfunction in a number of autoimmune diseases. Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with a documented increased level of intestinal inflammation, whereas multiple sclerosis (MS) is an organ-specific autoimmune disease known to exhibit increased intestinal permeability. In this study we determine to what extent intestinal inflammation, analysed by a faecal calprotectin ELISA, is accompanied by altered intestinal wall permeability, as measured by a lactulose and mannitol intestinal absorption assay. Intestinal permeability was increased in both pSS and MS patients, while faecal calprotectin was elevated in pSS but normal in MS. Our findings suggest different mechanisms mediating a leaky gut in these two diseases: in pSS there is autoimmune attack directly on the intestinal wall; in MS, with autoimmunity being limited to the CNS, it may be due to a disturbed CNS regulation of enteric nerve function.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Faecal calprotectin, Intestinal permeability, Lactulose/mannitol ratio, Multiple sclerosis, Primary Sjögren's syndrome
in
Journal of Translational Autoimmunity
volume
4
article number
100082
publisher
Elsevier
external identifiers
  • scopus:85099364203
  • pmid:33506194
ISSN
2589-9090
DOI
10.1016/j.jtauto.2021.100082
language
English
LU publication?
yes
id
8a30ebc0-d81d-4c3e-ae17-9d78dd9ac387
date added to LUP
2021-01-22 10:59:05
date last changed
2024-06-27 07:42:07
@article{8a30ebc0-d81d-4c3e-ae17-9d78dd9ac387,
  abstract     = {{<p>There is increasing evidence suggesting a role of intestinal dysfunction in a number of autoimmune diseases. Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with a documented increased level of intestinal inflammation, whereas multiple sclerosis (MS) is an organ-specific autoimmune disease known to exhibit increased intestinal permeability. In this study we determine to what extent intestinal inflammation, analysed by a faecal calprotectin ELISA, is accompanied by altered intestinal wall permeability, as measured by a lactulose and mannitol intestinal absorption assay. Intestinal permeability was increased in both pSS and MS patients, while faecal calprotectin was elevated in pSS but normal in MS. Our findings suggest different mechanisms mediating a leaky gut in these two diseases: in pSS there is autoimmune attack directly on the intestinal wall; in MS, with autoimmunity being limited to the CNS, it may be due to a disturbed CNS regulation of enteric nerve function.</p>}},
  author       = {{Sjöström, Bitte and Bredberg, Anders and Mandl, Thomas and Alonso-Magdalena, Lucía and Ohlsson, Bodil and Lavasani, Shahram and Nouri, Mehrnaz and Henriksson, Gunnel}},
  issn         = {{2589-9090}},
  keywords     = {{Faecal calprotectin; Intestinal permeability; Lactulose/mannitol ratio; Multiple sclerosis; Primary Sjögren's syndrome}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Translational Autoimmunity}},
  title        = {{Increased intestinal permeability in primary Sjögren's syndrome and multiple sclerosis}},
  url          = {{http://dx.doi.org/10.1016/j.jtauto.2021.100082}},
  doi          = {{10.1016/j.jtauto.2021.100082}},
  volume       = {{4}},
  year         = {{2021}},
}