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Intrauterine exposure to perfluorinated compounds and overweight at age 4 : A case-control study

Martinsson, Matilda LU orcid ; Nielsen, Christel LU orcid ; Björk, Jonas LU ; Rylander, Lars LU orcid ; Malmqvist, Ebba LU orcid ; Lindh, Christian LU orcid and Rignell-Hydbom, Anna LU (2020) In PLoS ONE 15(3).
Abstract

Aims The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overweight. Methods We used a case-control design and included 354 cases (ISO-BMI ≥ 18 kg/m2) and 2 controls per case (ISO-BMI ≤17 kg/m2) from child health care centers in Malmö, Sweden. Controls were selected stratified on risk scores for overweight in a propensity score framework. Maternal serum levels were analyzed in... (More)

Aims The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overweight. Methods We used a case-control design and included 354 cases (ISO-BMI ≥ 18 kg/m2) and 2 controls per case (ISO-BMI ≤17 kg/m2) from child health care centers in Malmö, Sweden. Controls were selected stratified on risk scores for overweight in a propensity score framework. Maternal serum levels were analyzed in biobanked samples collected by routine around gestational week 14. Logistic regression was used to estimate odds ratios between quartiles of maternal serum levels and child overweight at age 4. Results There were no consistent monotonic exposure-response relationships. We found some significant odds ratios in specific quartiles but these were regarded as spurious findings. The absence of an effect was consistent over risk strata. Conclusions We did not find evidence of an association between maternal serum levels of PFOS, PFOA, PFHxS and PFNA in early pregnancy and child overweight at age 4. The level of other risk factors for overweight did not affect children’s susceptibility to prenatal PFAS exposure.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
15
issue
3
article number
e0230137
publisher
Public Library of Science (PLoS)
external identifiers
  • pmid:32176721
  • scopus:85081982310
ISSN
1932-6203
DOI
10.1371/journal.pone.0230137
language
English
LU publication?
yes
id
8a5db8f5-0966-4af7-ae72-1540114d3765
date added to LUP
2020-03-30 08:21:24
date last changed
2024-08-07 16:29:14
@article{8a5db8f5-0966-4af7-ae72-1540114d3765,
  abstract     = {{<p>Aims The aims were to investigate the association between maternal serum levels of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS) and perfluorononanoic acid (PFNA) in early pregnancy and overweight in the child at 4 years and to assess potential heterogeneity in exposure effect between strata with different levels of other risk factors for overweight. Methods We used a case-control design and included 354 cases (ISO-BMI ≥ 18 kg/m<sup>2</sup>) and 2 controls per case (ISO-BMI ≤17 kg/m<sup>2</sup>) from child health care centers in Malmö, Sweden. Controls were selected stratified on risk scores for overweight in a propensity score framework. Maternal serum levels were analyzed in biobanked samples collected by routine around gestational week 14. Logistic regression was used to estimate odds ratios between quartiles of maternal serum levels and child overweight at age 4. Results There were no consistent monotonic exposure-response relationships. We found some significant odds ratios in specific quartiles but these were regarded as spurious findings. The absence of an effect was consistent over risk strata. Conclusions We did not find evidence of an association between maternal serum levels of PFOS, PFOA, PFHxS and PFNA in early pregnancy and child overweight at age 4. The level of other risk factors for overweight did not affect children’s susceptibility to prenatal PFAS exposure.</p>}},
  author       = {{Martinsson, Matilda and Nielsen, Christel and Björk, Jonas and Rylander, Lars and Malmqvist, Ebba and Lindh, Christian and Rignell-Hydbom, Anna}},
  issn         = {{1932-6203}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{3}},
  publisher    = {{Public Library of Science (PLoS)}},
  series       = {{PLoS ONE}},
  title        = {{Intrauterine exposure to perfluorinated compounds and overweight at age 4 : A case-control study}},
  url          = {{http://dx.doi.org/10.1371/journal.pone.0230137}},
  doi          = {{10.1371/journal.pone.0230137}},
  volume       = {{15}},
  year         = {{2020}},
}