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Serum copper, zinc and copper/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study

Bengtsson, Ylva LU orcid ; Demircan, Kamil ; Vallon-Christersson, Johan LU orcid ; Malmberg, Martin ; Saal, Lao LU orcid ; Ryden, Lisa LU orcid ; Borg, Åke LU ; Schomburg, Lutz ; Sandsveden, Malte LU and Manjer, Jonas LU (2023) In Redox Biology 63.
Abstract
Background
The essential trace elements copper and zinc, and their ratio (copper/zinc), are important for maintaining redox homeostasis. Previous studies suggest that these elements may impact breast cancer survival. However, no epidemiological study has so far been conducted on the potential association between copper and copper/zinc levels and survival after breast cancer diagnosis. In this study, we aimed to examine the relationship between serum copper, zinc and copper/zinc levels and survival following breast cancer diagnosis.

Patients and methods
The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a population-based cohort study including multiple participating hospitals in Sweden. A total of 1998... (More)
Background
The essential trace elements copper and zinc, and their ratio (copper/zinc), are important for maintaining redox homeostasis. Previous studies suggest that these elements may impact breast cancer survival. However, no epidemiological study has so far been conducted on the potential association between copper and copper/zinc levels and survival after breast cancer diagnosis. In this study, we aimed to examine the relationship between serum copper, zinc and copper/zinc levels and survival following breast cancer diagnosis.

Patients and methods
The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a population-based cohort study including multiple participating hospitals in Sweden. A total of 1998 patients diagnosed with primary invasive breast cancer were followed for approximately nine years. Serum levels of copper and zinc and their ratio at the time of diagnosis was analyzed in relation to breast cancer survival using multivariate Cox regression, yielding hazard ratios (HR) with 95% confidence intervals.

Results
A higher copper/zinc ratio was associated with lower overall survival after breast cancer diagnosis. Comparing patients with a copper/zinc ratio in quartile 4 vs 1, the crude HR was 2.29 (1.65–3.19) (Ptrend
Conclusion
There is evidence that the serum copper/zinc ratio provides an independent predictive value for overall survival following breast cancer diagnosis. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Redox Biology
volume
63
article number
102728
publisher
Elsevier
external identifiers
  • scopus:85159567397
  • pmid:37210781
ISSN
2213-2317
DOI
10.1016/j.redox.2023.102728
project
Sweden Cancerome Analysis Network - Breast (SCAN-B): a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine
Trace Elements and Breast Cancer: Selenium, Zinc and Copper in Relation to Risk and Prognosis
language
English
LU publication?
yes
id
8af4f2e9-33b7-4553-9956-05817ab1353e
date added to LUP
2023-06-29 15:42:21
date last changed
2023-11-09 15:20:55
@article{8af4f2e9-33b7-4553-9956-05817ab1353e,
  abstract     = {{Background<br/>The essential trace elements copper and zinc, and their ratio (copper/zinc), are important for maintaining redox homeostasis. Previous studies suggest that these elements may impact breast cancer survival. However, no epidemiological study has so far been conducted on the potential association between copper and copper/zinc levels and survival after breast cancer diagnosis. In this study, we aimed to examine the relationship between serum copper, zinc and copper/zinc levels and survival following breast cancer diagnosis.<br/><br/>Patients and methods<br/>The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a population-based cohort study including multiple participating hospitals in Sweden. A total of 1998 patients diagnosed with primary invasive breast cancer were followed for approximately nine years. Serum levels of copper and zinc and their ratio at the time of diagnosis was analyzed in relation to breast cancer survival using multivariate Cox regression, yielding hazard ratios (HR) with 95% confidence intervals.<br/><br/>Results<br/>A higher copper/zinc ratio was associated with lower overall survival after breast cancer diagnosis. Comparing patients with a copper/zinc ratio in quartile 4 vs 1, the crude HR was 2.29 (1.65–3.19) (Ptrend <br/>Conclusion<br/>There is evidence that the serum copper/zinc ratio provides an independent predictive value for overall survival following breast cancer diagnosis.}},
  author       = {{Bengtsson, Ylva and Demircan, Kamil and Vallon-Christersson, Johan and Malmberg, Martin and Saal, Lao and Ryden, Lisa and Borg, Åke and Schomburg, Lutz and Sandsveden, Malte and Manjer, Jonas}},
  issn         = {{2213-2317}},
  language     = {{eng}},
  month        = {{05}},
  publisher    = {{Elsevier}},
  series       = {{Redox Biology}},
  title        = {{Serum copper, zinc and copper/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study}},
  url          = {{http://dx.doi.org/10.1016/j.redox.2023.102728}},
  doi          = {{10.1016/j.redox.2023.102728}},
  volume       = {{63}},
  year         = {{2023}},
}