Gd‐DTPA2–‐enhanced MRI of femoral knee cartilage: A dose‐response study in healthy volunteers
Tiderius, C J LU ; Olsson, L E LU
; de Verdier, H
; Leander, P
LU
; Ekberg, O
LU
and Dahlberg, L
LU
(2001)
In Magnetic Resonance in Medicine
46(6).
p.71-1067
- Abstract
The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an... (More)
The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an intravenous injection of Gd-DTPA2- at single, double, and triple doses: 0.1, 0.2, and 0.3 mmol/kg body weight, respectively. The increase in R1 postcontrast was linearly dose-related at all times. The highest R1 values were registered at 2 and 3 h postcontrast, suggesting 2 h to be optimal in the clinical situation. The triple dose indicated a subtle compartmental difference in men, with higher contrast distribution medially than laterally. Results suggest that the triple dose is needed to detect minor cartilage matrix differences.
(Less)
- author
- Tiderius, C J
LU
; Olsson, L E
LU
; de Verdier, H
; Leander, P
LU
; Ekberg, O
LU
and Dahlberg, L
LU
- organization
- publishing date
- 2001-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Cartilage, Articular, Contrast Media, Dose-Response Relationship, Drug, Female, Gadolinium DTPA, Humans, Knee Joint, Magnetic Resonance Imaging, Male
- in
- Magnetic Resonance in Medicine
- volume
- 46
- issue
- 6
- pages
- 5 pages
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0034747168
- pmid:11746570
- ISSN
- 0740-3194
- DOI
- 10.1002/mrm.1300
- language
- English
- LU publication?
- yes
- id
- 8b2b4cc3-b27b-474b-9c7e-d8433232ddc3
- date added to LUP
- 2016-08-16 12:13:35
- date last changed
- 2025-10-14 11:08:09
@article{8b2b4cc3-b27b-474b-9c7e-d8433232ddc3,
abstract = {{<p>The negatively charged contrast agent Gd-DTPA2- distributes inversely to the cartilage fixed charged density. This enables structural cartilage examinations by contrast-enhanced MRI. In line with the development of a clinically applicable protocol for such examinations, this study describes the temporal pattern of Gd-DTPA2- distribution in femoral knee cartilage at three different doses in healthy volunteers. Nineteen volunteers (ages 21-28 years) were examined with a 1.5T MRI system. Quantitative relaxation rate measurements were made in weight-bearing central parts of femoral cartilage using sets of five turbo inversion recovery images with different inversion times. The cartilage was analyzed before and four times (1-4 h) after an intravenous injection of Gd-DTPA2- at single, double, and triple doses: 0.1, 0.2, and 0.3 mmol/kg body weight, respectively. The increase in R1 postcontrast was linearly dose-related at all times. The highest R1 values were registered at 2 and 3 h postcontrast, suggesting 2 h to be optimal in the clinical situation. The triple dose indicated a subtle compartmental difference in men, with higher contrast distribution medially than laterally. Results suggest that the triple dose is needed to detect minor cartilage matrix differences.</p>}},
author = {{Tiderius, C J and Olsson, L E and de Verdier, H and Leander, P and Ekberg, O and Dahlberg, L}},
issn = {{0740-3194}},
keywords = {{Adult; Cartilage, Articular; Contrast Media; Dose-Response Relationship, Drug; Female; Gadolinium DTPA; Humans; Knee Joint; Magnetic Resonance Imaging; Male}},
language = {{eng}},
number = {{6}},
pages = {{71--1067}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Magnetic Resonance in Medicine}},
title = {{Gd‐DTPA2–‐enhanced MRI of femoral knee cartilage: A dose‐response study in healthy volunteers}},
url = {{http://dx.doi.org/10.1002/mrm.1300}},
doi = {{10.1002/mrm.1300}},
volume = {{46}},
year = {{2001}},
}