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Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome

Carlsson, Annelie LU ; Axelsson, Irene LU ; Borulf, Stefan LU ; Bredberg, Anders LU ; Forslund, Marianne; Lindberg, Bengt LU ; Sjöberg, Klas LU and Ivarsson, Sten-Anders LU (1998) In Pediatrics 101(2). p.5-272
Abstract

OBJECTIVE: This study was undertaken to investigate the prevalence of celiac disease in children and adolescents with Down syndrome.

MATERIAL AND METHODS: Forty-three children and adolescents with Down syndrome were screened for IgA-antigliadin antibodies (AGA) and IgA-antiendomysium antibodies (EMA). Patients found to be either AGA- or EMA-positive were investigated further with intestinal biopsy.

RESULTS: None of the 43 patients had known celiac disease at entry into the study; 37% (16/43) were found to have AGA levels above normal, and 16% (7/43) to be EMA-positive. Of the 15 patients who underwent biopsy, 8 manifested villous atrophy. Villous atrophy was present in all 7 of the EMA-positive patients, whereas the villi... (More)

OBJECTIVE: This study was undertaken to investigate the prevalence of celiac disease in children and adolescents with Down syndrome.

MATERIAL AND METHODS: Forty-three children and adolescents with Down syndrome were screened for IgA-antigliadin antibodies (AGA) and IgA-antiendomysium antibodies (EMA). Patients found to be either AGA- or EMA-positive were investigated further with intestinal biopsy.

RESULTS: None of the 43 patients had known celiac disease at entry into the study; 37% (16/43) were found to have AGA levels above normal, and 16% (7/43) to be EMA-positive. Of the 15 patients who underwent biopsy, 8 manifested villous atrophy. Villous atrophy was present in all 7 of the EMA-positive patients, whereas the villi were normal in 7 of the 13 AGA-positive patients who underwent biopsy.

CONCLUSIONS: EMA is a good immunologic marker for use in screening for celiac disease, and screening is justified in patients with Down syndrome.

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organization
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Contribution to journal
publication status
published
subject
keywords
Adolescent, Autoantibodies, Biomarkers, Celiac Disease, Child, Child, Preschool, Down Syndrome, Gliadin, Humans, Immunoglobulin A, Intestine, Small, Muscle Fibers, Skeletal, Prevalence, Journal Article, Research Support, Non-U.S. Gov't
in
Pediatrics
volume
101
issue
2
pages
5 - 272
publisher
American Academy of Pediatrics
external identifiers
  • scopus:0031886498
ISSN
1098-4275
DOI
10.1542/peds.101.2.272
language
English
LU publication?
yes
id
8b8c9d3b-16dd-4fff-96d5-3067c92f33b8
date added to LUP
2017-11-09 11:40:42
date last changed
2017-11-12 04:36:36
@article{8b8c9d3b-16dd-4fff-96d5-3067c92f33b8,
  abstract     = {<p>OBJECTIVE: This study was undertaken to investigate the prevalence of celiac disease in children and adolescents with Down syndrome.</p><p>MATERIAL AND METHODS: Forty-three children and adolescents with Down syndrome were screened for IgA-antigliadin antibodies (AGA) and IgA-antiendomysium antibodies (EMA). Patients found to be either AGA- or EMA-positive were investigated further with intestinal biopsy.</p><p>RESULTS: None of the 43 patients had known celiac disease at entry into the study; 37% (16/43) were found to have AGA levels above normal, and 16% (7/43) to be EMA-positive. Of the 15 patients who underwent biopsy, 8 manifested villous atrophy. Villous atrophy was present in all 7 of the EMA-positive patients, whereas the villi were normal in 7 of the 13 AGA-positive patients who underwent biopsy.</p><p>CONCLUSIONS: EMA is a good immunologic marker for use in screening for celiac disease, and screening is justified in patients with Down syndrome.</p>},
  author       = {Carlsson, Annelie and Axelsson, Irene and Borulf, Stefan and Bredberg, Anders and Forslund, Marianne and Lindberg, Bengt and Sjöberg, Klas and Ivarsson, Sten-Anders},
  issn         = {1098-4275},
  keyword      = {Adolescent,Autoantibodies,Biomarkers,Celiac Disease,Child,Child, Preschool,Down Syndrome,Gliadin,Humans,Immunoglobulin A,Intestine, Small,Muscle Fibers, Skeletal,Prevalence,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {2},
  pages        = {5--272},
  publisher    = {American Academy of Pediatrics},
  series       = {Pediatrics},
  title        = {Prevalence of IgA-antigliadin antibodies and IgA-antiendomysium antibodies related to celiac disease in children with Down syndrome},
  url          = {http://dx.doi.org/10.1542/peds.101.2.272},
  volume       = {101},
  year         = {1998},
}