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Relationship Between Ljungan Virus Antibodies, HLA-DQ8, and Insulin Autoantibodies in Newly Diagnosed Type 1 Diabetes Children

Nilsson, Anna-Lena LU ; Vaziri Sani, Fariba LU ; Andersson, Cecilia K LU ; Larsson, Karin LU ; Carlsson, Annelie LU ; Cedervall, Elisabeth; Jonsson, Bjorn; Neiderud, Jan; Larsson, Helena LU and Ivarsson, Sten LU , et al. (2013) In Viral Immunology 26(3). p.207-215
Abstract
Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet autoantibodies in newly diagnosed T1D patients (n = 676) and controls (n = 309). Patients, 0-18 years of age, diagnosed with T1D in 1996-2005 were analyzed for LVAb, HLA-DQ genotypes, and all seven known islet autoantibodies (GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, and ZnT8QA). LVAb at 75th percentile, defined as cut off, was 90 (range 6-3936) U/mL... (More)
Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet autoantibodies in newly diagnosed T1D patients (n = 676) and controls (n = 309). Patients, 0-18 years of age, diagnosed with T1D in 1996-2005 were analyzed for LVAb, HLA-DQ genotypes, and all seven known islet autoantibodies (GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, and ZnT8QA). LVAb at 75th percentile, defined as cut off, was 90 (range 6-3936) U/mL and 4th quartile LVAb were found in 25% (170/676) of which 64% were < 10 (n = 108, p < 0.0001), and 27% were < 5 (n = 45; p < 0.0001) years old. The 4th quartile LVAb in children < 10 years of age correlated to HLA DQ2/8, 8/8, and 8/X (p < 0.0001). Furthermore, in the group with 4th quartile LVAb, 55% were IAA positive (p = 0.01) and correlation was found between 4th quartile LVAb and IAA in children < 10 years of age (p = 0.035). It is concluded that 1) LVAb were common among the young T1D patients and LVAb levels were higher in the younger age groups; 2) 4th quartile LVAb correlated with IAA; and 3) there was a correlation between 4th quartile LVAb and HLA-DQ8, particularly in the young patients. The presence of LVAb supports the notion that prior exposure to LV may be associated with T1D. (Less)
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Contribution to journal
publication status
published
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Viral Immunology
volume
26
issue
3
pages
207 - 215
publisher
Mary Ann Liebert, Inc.
external identifiers
  • wos:000320506100007
  • scopus:84879166705
ISSN
0882-8245
DOI
10.1089/vim.2013.0008
language
English
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yes
id
8c62a137-5540-4ba1-b670-53ac9ec01d06 (old id 3979893)
date added to LUP
2013-09-02 13:27:11
date last changed
2019-05-05 03:44:25
@article{8c62a137-5540-4ba1-b670-53ac9ec01d06,
  abstract     = {Environmental factors, including viral infections, may explain an increasing and fluctuating incidence of childhood type 1 diabetes (T1D). Ljungan virus (LV) isolated from bank voles have been implicated, but it is unclear whether LV contributes to islet autoimmunity, progression to clinical onset, or both, of T1D. The aim was to test whether LV antibodies (LVAb) were related to HLA-DQ and islet autoantibodies in newly diagnosed T1D patients (n = 676) and controls (n = 309). Patients, 0-18 years of age, diagnosed with T1D in 1996-2005 were analyzed for LVAb, HLA-DQ genotypes, and all seven known islet autoantibodies (GADA, IA-2A, IAA, ICA, ZnT8RA, ZnT8WA, and ZnT8QA). LVAb at 75th percentile, defined as cut off, was 90 (range 6-3936) U/mL and 4th quartile LVAb were found in 25% (170/676) of which 64% were &lt; 10 (n = 108, p &lt; 0.0001), and 27% were &lt; 5 (n = 45; p &lt; 0.0001) years old. The 4th quartile LVAb in children &lt; 10 years of age correlated to HLA DQ2/8, 8/8, and 8/X (p &lt; 0.0001). Furthermore, in the group with 4th quartile LVAb, 55% were IAA positive (p = 0.01) and correlation was found between 4th quartile LVAb and IAA in children &lt; 10 years of age (p = 0.035). It is concluded that 1) LVAb were common among the young T1D patients and LVAb levels were higher in the younger age groups; 2) 4th quartile LVAb correlated with IAA; and 3) there was a correlation between 4th quartile LVAb and HLA-DQ8, particularly in the young patients. The presence of LVAb supports the notion that prior exposure to LV may be associated with T1D.},
  author       = {Nilsson, Anna-Lena and Vaziri Sani, Fariba and Andersson, Cecilia K and Larsson, Karin and Carlsson, Annelie and Cedervall, Elisabeth and Jonsson, Bjorn and Neiderud, Jan and Larsson, Helena and Ivarsson, Sten and Lernmark, Åke},
  issn         = {0882-8245},
  language     = {eng},
  number       = {3},
  pages        = {207--215},
  publisher    = {Mary Ann Liebert, Inc.},
  series       = {Viral Immunology},
  title        = {Relationship Between Ljungan Virus Antibodies, HLA-DQ8, and Insulin Autoantibodies in Newly Diagnosed Type 1 Diabetes Children},
  url          = {http://dx.doi.org/10.1089/vim.2013.0008},
  volume       = {26},
  year         = {2013},
}