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Timing in Purkinje Cells and a Novel Learning Mechanism

Hesslow, Germund LU ; Jirenhed, Dan Anders LU and Johansson, Fredrik LU (2021) In Contemporary Clinical Neuroscience p.327-335
Abstract

During eyeblink conditioning, Purkinje cells that control the eyelid learn to respond with a pause in simple spike firing to the conditional stimulus. This conditional pause response (CR) in the Purkinje cell is adaptively timed and drives the overt response. Recent results show that the Purkinje cell CR does not depend on modification of synaptic strength such as long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and to time of the CR accordingly. The Purkinje cell CR is elicited by glutamate acting on metabotropic receptors (mGluR7) and may involve inwardly rectifying potassium channels (Kir3).

Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Contemporary Clinical Neuroscience
series title
Contemporary Clinical Neuroscience
editor
Mizusawa, Hidehiro and Kakei, Shinji
pages
9 pages
publisher
Springer
external identifiers
  • scopus:85119159898
ISSN
2627-535X
2627-5341
ISBN
978-3-030-75816-5
978-3-030-75817-2
DOI
10.1007/978-3-030-75817-2_15
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, Springer Nature Switzerland AG.
id
8c913365-2128-48c8-b5a9-24be2d556541
date added to LUP
2021-12-03 14:58:08
date last changed
2025-01-13 19:22:58
@inbook{8c913365-2128-48c8-b5a9-24be2d556541,
  abstract     = {{<p>During eyeblink conditioning, Purkinje cells that control the eyelid learn to respond with a pause in simple spike firing to the conditional stimulus. This conditional pause response (CR) in the Purkinje cell is adaptively timed and drives the overt response. Recent results show that the Purkinje cell CR does not depend on modification of synaptic strength such as long-term depression but on a novel mechanism that enables the cell to learn the temporal interval between conditional and unconditional stimuli and to time of the CR accordingly. The Purkinje cell CR is elicited by glutamate acting on metabotropic receptors (mGluR7) and may involve inwardly rectifying potassium channels (K<sub>ir</sub>3).</p>}},
  author       = {{Hesslow, Germund and Jirenhed, Dan Anders and Johansson, Fredrik}},
  booktitle    = {{Contemporary Clinical Neuroscience}},
  editor       = {{Mizusawa, Hidehiro and Kakei, Shinji}},
  isbn         = {{978-3-030-75816-5}},
  issn         = {{2627-535X}},
  language     = {{eng}},
  pages        = {{327--335}},
  publisher    = {{Springer}},
  series       = {{Contemporary Clinical Neuroscience}},
  title        = {{Timing in Purkinje Cells and a Novel Learning Mechanism}},
  url          = {{http://dx.doi.org/10.1007/978-3-030-75817-2_15}},
  doi          = {{10.1007/978-3-030-75817-2_15}},
  year         = {{2021}},
}