Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis

Khan, Faisel ; Gonçalves, Isabel LU orcid ; Shore, Angela C. ; Natali, Andrea ; Palombo, Carlo ; Colhoun, Helen M. ; Östling, Gerd LU ; Casanova, Francesco ; Kennbäck, Cecilia LU and Aizawa, Kunihiko , et al. (2022) In Cell Reports Medicine 3(7).
Abstract

The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] −0.14 [−0.06 to −0.02] p = 0.001, 0.15... (More)

The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] −0.14 [−0.06 to −0.02] p = 0.001, 0.15 [0.02–0.07] p = 0.001, and 0.20 [0.03–0.07] p < 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15–0.29] p < 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
atherosclerosis, biomarkers, carotid ultrasound, intima-media thickness, risk factors, type 2 diabetes
in
Cell Reports Medicine
volume
3
issue
7
article number
100676
publisher
Elsevier
external identifiers
  • pmid:35858591
  • scopus:85134730726
ISSN
2666-3791
DOI
10.1016/j.xcrm.2022.100676
language
English
LU publication?
yes
id
8cc9b1ab-7499-4a58-b11e-6d324bedc4b7
date added to LUP
2022-10-10 10:47:17
date last changed
2024-06-13 12:39:45
@article{8cc9b1ab-7499-4a58-b11e-6d324bedc4b7,
  abstract     = {{<p>The factors that influence the atherosclerotic disease process in high-risk individuals remain poorly understood. Here, we used a combination of vascular imaging, risk factor assessment, and biomarkers to identify factors associated with 3-year change in carotid disease severity in a cohort of high-risk subjects treated with preventive therapy (n = 865). The results show that changes in intima-media thickness (IMT) are most pronounced in the carotid bulb. Progression of bulb IMT demonstrates independent associations with baseline bulb IMT, the plaque gray scale median (GSM), and the plasma level of platelet-derived growth factor (PDGF) (standardized β-coefficients and 95% confidence interval [CI] −0.14 [−0.06 to −0.02] p = 0.001, 0.15 [0.02–0.07] p = 0.001, and 0.20 [0.03–0.07] p &lt; 0.001, respectively). Plasma PDGF correlates with the plaque GSM (0.23 [0.15–0.29] p &lt; 0.001). These observations provide insight into the atherosclerotic process in high-risk subjects by showing that progression primarily occurs in fibrotic plaques and is associated with increased levels of PDGF.</p>}},
  author       = {{Khan, Faisel and Gonçalves, Isabel and Shore, Angela C. and Natali, Andrea and Palombo, Carlo and Colhoun, Helen M. and Östling, Gerd and Casanova, Francesco and Kennbäck, Cecilia and Aizawa, Kunihiko and Persson, Margaretha and Gooding, Kim M. and Strain, David and Looker, Helen and Dove, Fiona and Belch, Jill and Pinnola, Silvia and Venturi, Elena and Kozakova, Michaela and Nilsson, Jan}},
  issn         = {{2666-3791}},
  keywords     = {{atherosclerosis; biomarkers; carotid ultrasound; intima-media thickness; risk factors; type 2 diabetes}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  publisher    = {{Elsevier}},
  series       = {{Cell Reports Medicine}},
  title        = {{Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis}},
  url          = {{http://dx.doi.org/10.1016/j.xcrm.2022.100676}},
  doi          = {{10.1016/j.xcrm.2022.100676}},
  volume       = {{3}},
  year         = {{2022}},
}