Caffeine Intake, Plasma Caffeine Level, and Kidney Function : A Mendelian Randomization Study
(2023) In Nutrients 15(20).- Abstract
Caffeine is a psychoactive substance widely consumed worldwide, mainly via sources such as coffee and tea. The effects of caffeine on kidney function remain unclear. We leveraged the genetic variants in the CYP1A2 and AHR genes via the two-sample Mendelian randomization (MR) framework to estimate the association of genetically predicted plasma caffeine and caffeine intake on kidney traits. Genetic association summary statistics on plasma caffeine levels and caffeine intake were taken from genome-wide association study (GWAS) meta-analyses of 9876 and of >47,000 European ancestry individuals, respectively. Genetically predicted plasma caffeine levels were associated with a decrease in estimated glomerular filtration rate (eGFR)... (More)
Caffeine is a psychoactive substance widely consumed worldwide, mainly via sources such as coffee and tea. The effects of caffeine on kidney function remain unclear. We leveraged the genetic variants in the CYP1A2 and AHR genes via the two-sample Mendelian randomization (MR) framework to estimate the association of genetically predicted plasma caffeine and caffeine intake on kidney traits. Genetic association summary statistics on plasma caffeine levels and caffeine intake were taken from genome-wide association study (GWAS) meta-analyses of 9876 and of >47,000 European ancestry individuals, respectively. Genetically predicted plasma caffeine levels were associated with a decrease in estimated glomerular filtration rate (eGFR) measured using either creatinine or cystatin C. In contrast, genetically predicted caffeine intake was associated with an increase in eGFR and a low risk of chronic kidney disease. The discrepancy is likely attributable to faster metabolizers of caffeine consuming more caffeine-containing beverages to achieve the same pharmacological effect. Further research is needed to distinguish whether the observed effects on kidney function are driven by the harmful effects of higher plasma caffeine levels or the protective effects of greater intake of caffeine-containing beverages, particularly given the widespread use of drinks containing caffeine and the increasing burden of kidney disease.
(Less)
- author
- Giontella, Alice
LU
; de La Harpe, Roxane ; Cronje, Héléne T. ; Zagkos, Loukas ; Woolf, Benjamin ; Larsson, Susanna C. and Gill, Dipender
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- caffeine intake, caffeine level, causal inference, estimated glomerular filtration rate, genetically predicted coffee consumption, kidney function, Mendelian randomization
- in
- Nutrients
- volume
- 15
- issue
- 20
- article number
- 4422
- publisher
- MDPI AG
- external identifiers
-
- scopus:85175448182
- pmid:37892497
- ISSN
- 2072-6643
- DOI
- 10.3390/nu15204422
- language
- English
- LU publication?
- yes
- id
- 8dbe1a67-1422-44ca-9b10-b726eaa1e305
- date added to LUP
- 2023-11-24 09:43:09
- date last changed
- 2025-02-10 17:13:33
@article{8dbe1a67-1422-44ca-9b10-b726eaa1e305, abstract = {{<p>Caffeine is a psychoactive substance widely consumed worldwide, mainly via sources such as coffee and tea. The effects of caffeine on kidney function remain unclear. We leveraged the genetic variants in the CYP1A2 and AHR genes via the two-sample Mendelian randomization (MR) framework to estimate the association of genetically predicted plasma caffeine and caffeine intake on kidney traits. Genetic association summary statistics on plasma caffeine levels and caffeine intake were taken from genome-wide association study (GWAS) meta-analyses of 9876 and of >47,000 European ancestry individuals, respectively. Genetically predicted plasma caffeine levels were associated with a decrease in estimated glomerular filtration rate (eGFR) measured using either creatinine or cystatin C. In contrast, genetically predicted caffeine intake was associated with an increase in eGFR and a low risk of chronic kidney disease. The discrepancy is likely attributable to faster metabolizers of caffeine consuming more caffeine-containing beverages to achieve the same pharmacological effect. Further research is needed to distinguish whether the observed effects on kidney function are driven by the harmful effects of higher plasma caffeine levels or the protective effects of greater intake of caffeine-containing beverages, particularly given the widespread use of drinks containing caffeine and the increasing burden of kidney disease.</p>}}, author = {{Giontella, Alice and de La Harpe, Roxane and Cronje, Héléne T. and Zagkos, Loukas and Woolf, Benjamin and Larsson, Susanna C. and Gill, Dipender}}, issn = {{2072-6643}}, keywords = {{caffeine intake; caffeine level; causal inference; estimated glomerular filtration rate; genetically predicted coffee consumption; kidney function; Mendelian randomization}}, language = {{eng}}, number = {{20}}, publisher = {{MDPI AG}}, series = {{Nutrients}}, title = {{Caffeine Intake, Plasma Caffeine Level, and Kidney Function : A Mendelian Randomization Study}}, url = {{http://dx.doi.org/10.3390/nu15204422}}, doi = {{10.3390/nu15204422}}, volume = {{15}}, year = {{2023}}, }