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Morphometric analysis of thalamic volume in progressive supranuclear palsy : In vivo evidence of regionally specific bilateral thalamic atrophy

Power, Brian D.; Jakabek, David; Hunter-Dickson, Mitchell; Wilkes, Fiona A.; van Westen, Danielle LU ; Santillo, Alexander F. LU ; Walterfang, Mark; Velakoulis, Dennis; Nilsson, Christer LU and Looi, Jeffrey C. L. (2017) In Psychiatry Research - Neuroimaging 265. p.65-71
Abstract

We investigated whether differences were detectable in the volume and shape of the dorsal thalamus on magnetic resonance imaging in patients with progressive supranuclear palsy (PSP). Manual segmentation of the left and right thalami on magnetic resonance imaging scans occurred in 22 patients with clinically diagnosed PSP and 23 healthy controls; thalamic volumes (left, right, total) were calculated. Between group differences were explored by multivariate analysis of co-variance, using age and intracranial volume as covariates. Analysis of the shape of the thalamus was performed using the spherical harmonic point distribution method software package. Patients with PSP were found to have significant bilateral thalamic atrophy on magnetic... (More)

We investigated whether differences were detectable in the volume and shape of the dorsal thalamus on magnetic resonance imaging in patients with progressive supranuclear palsy (PSP). Manual segmentation of the left and right thalami on magnetic resonance imaging scans occurred in 22 patients with clinically diagnosed PSP and 23 healthy controls; thalamic volumes (left, right, total) were calculated. Between group differences were explored by multivariate analysis of co-variance, using age and intracranial volume as covariates. Analysis of the shape of the thalamus was performed using the spherical harmonic point distribution method software package. Patients with PSP were found to have significant bilateral thalamic atrophy on magnetic resonance imaging; there was significant shape deflation over the anterior-lateral and anterior-ventral surfaces bilaterally, and over the right caudal thalamus. Recognizing decreased thalamic morphology in PSP patients in vivo may be an important component of an ensemble of diagnostic biomarkers in the future, particularly given the difficulty of distinguishing PSP from other Parkinsonian conditions early in the disease course.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atrophy, Magnetic resonance imaging, Morphology, Progressive supranuclear palsy, Thalamus
in
Psychiatry Research - Neuroimaging
volume
265
pages
65 - 71
publisher
Elsevier
external identifiers
  • scopus:85019547362
  • wos:000405053200008
ISSN
0925-4927
DOI
10.1016/j.pscychresns.2017.05.004
language
English
LU publication?
yes
id
8e3b0ca5-1226-4473-82df-4490c6bf5b9f
date added to LUP
2017-06-16 11:31:40
date last changed
2017-09-18 11:41:34
@article{8e3b0ca5-1226-4473-82df-4490c6bf5b9f,
  abstract     = {<p>We investigated whether differences were detectable in the volume and shape of the dorsal thalamus on magnetic resonance imaging in patients with progressive supranuclear palsy (PSP). Manual segmentation of the left and right thalami on magnetic resonance imaging scans occurred in 22 patients with clinically diagnosed PSP and 23 healthy controls; thalamic volumes (left, right, total) were calculated. Between group differences were explored by multivariate analysis of co-variance, using age and intracranial volume as covariates. Analysis of the shape of the thalamus was performed using the spherical harmonic point distribution method software package. Patients with PSP were found to have significant bilateral thalamic atrophy on magnetic resonance imaging; there was significant shape deflation over the anterior-lateral and anterior-ventral surfaces bilaterally, and over the right caudal thalamus. Recognizing decreased thalamic morphology in PSP patients in vivo may be an important component of an ensemble of diagnostic biomarkers in the future, particularly given the difficulty of distinguishing PSP from other Parkinsonian conditions early in the disease course.</p>},
  author       = {Power, Brian D. and Jakabek, David and Hunter-Dickson, Mitchell and Wilkes, Fiona A. and van Westen, Danielle and Santillo, Alexander F. and Walterfang, Mark and Velakoulis, Dennis and Nilsson, Christer and Looi, Jeffrey C. L.},
  issn         = {0925-4927},
  keyword      = {Atrophy,Magnetic resonance imaging,Morphology,Progressive supranuclear palsy,Thalamus},
  language     = {eng},
  month        = {07},
  pages        = {65--71},
  publisher    = {Elsevier},
  series       = {Psychiatry Research - Neuroimaging},
  title        = {Morphometric analysis of thalamic volume in progressive supranuclear palsy : In vivo evidence of regionally specific bilateral thalamic atrophy},
  url          = {http://dx.doi.org/10.1016/j.pscychresns.2017.05.004},
  volume       = {265},
  year         = {2017},
}