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Prostaglandin E(2) and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: No impact on survival of seizure-generated neurons.

Ajmone-Cat, Maria Antonietta ; Iosif, Robert LU ; Ekdahl Clementson, Christine LU ; Kokaia, Zaal LU ; Minghetti, Luisa and Lindvall, Olle LU (2006) In Neurobiology of Disease 23(1). p.23-35
Abstract
Partial and generalized status epilepticus (pSE and gSE) trigger the same level of progenitor cell proliferation in adult dentate gyrus, but survival of new neurons is poor after gSE. Here, we show markedly elevated levels of prostaglandin E-2 (PGE(2)) and brain-derived neurotrophic factor (BDNF) in rat hippocampal formation at 7 days following pSE but not gSE. Administration of the cyclooxygenase (COX) inhibitor flurbiprofen for 1 week, starting at day 8 post-SE, abated PGE(2) and decreased BDNF levels, but did not affect survival of new neurons a weeks later. Thus, high PGE(2) and BDNF levels induced by pSE are probably not of major importance for survival of new neurons during the first days after formation. We propose that they... (More)
Partial and generalized status epilepticus (pSE and gSE) trigger the same level of progenitor cell proliferation in adult dentate gyrus, but survival of new neurons is poor after gSE. Here, we show markedly elevated levels of prostaglandin E-2 (PGE(2)) and brain-derived neurotrophic factor (BDNF) in rat hippocampal formation at 7 days following pSE but not gSE. Administration of the cyclooxygenase (COX) inhibitor flurbiprofen for 1 week, starting at day 8 post-SE, abated PGE(2) and decreased BDNF levels, but did not affect survival of new neurons a weeks later. Thus, high PGE(2) and BDNF levels induced by pSE are probably not of major importance for survival of new neurons during the first days after formation. We propose that they modulate other aspects of synaptic and cellular plasticity, and thereby may influence epileptogenesis. (Less)
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organization
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Contribution to journal
publication status
published
subject
keywords
status epilepticus, flurbiprofen, neurogenesis, isoprostanes, EP3, EP2, neurotrophic factor (BDNF), brain-derived, prostaglandin E-2 (PGE(2)), cyclooxygenase-2 (COX-2)
in
Neurobiology of Disease
volume
23
issue
1
pages
23 - 35
publisher
Elsevier
external identifiers
  • pmid:16531049
  • wos:000238632300003
  • scopus:33745122517
  • pmid:16531049
ISSN
0969-9961
DOI
10.1016/j.nbd.2006.01.010
language
English
LU publication?
yes
id
8e62d94b-c1a4-4a36-a461-f6aaa59b4563 (old id 154702)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16531049&dopt=Abstract
date added to LUP
2016-04-01 12:34:55
date last changed
2020-01-12 10:05:44
@article{8e62d94b-c1a4-4a36-a461-f6aaa59b4563,
  abstract     = {Partial and generalized status epilepticus (pSE and gSE) trigger the same level of progenitor cell proliferation in adult dentate gyrus, but survival of new neurons is poor after gSE. Here, we show markedly elevated levels of prostaglandin E-2 (PGE(2)) and brain-derived neurotrophic factor (BDNF) in rat hippocampal formation at 7 days following pSE but not gSE. Administration of the cyclooxygenase (COX) inhibitor flurbiprofen for 1 week, starting at day 8 post-SE, abated PGE(2) and decreased BDNF levels, but did not affect survival of new neurons a weeks later. Thus, high PGE(2) and BDNF levels induced by pSE are probably not of major importance for survival of new neurons during the first days after formation. We propose that they modulate other aspects of synaptic and cellular plasticity, and thereby may influence epileptogenesis.},
  author       = {Ajmone-Cat, Maria Antonietta and Iosif, Robert and Ekdahl Clementson, Christine and Kokaia, Zaal and Minghetti, Luisa and Lindvall, Olle},
  issn         = {0969-9961},
  language     = {eng},
  number       = {1},
  pages        = {23--35},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {Prostaglandin E(2) and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: No impact on survival of seizure-generated neurons.},
  url          = {http://dx.doi.org/10.1016/j.nbd.2006.01.010},
  doi          = {10.1016/j.nbd.2006.01.010},
  volume       = {23},
  year         = {2006},
}