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Optogenetic control of human neurons in organotypic brain cultures

Andersson, My LU ; Avaliani, Natalia; Svensson, Andreas LU ; Wickham, Jenny LU ; Pinborg, Lars H.; Jespersen, Bo; Christiansen, Søren H.; Bengzon, Johan LU ; Woldbye, David P D and Kokaia, Merab LU (2016) In Scientific Reports 6.
Abstract

Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
6
publisher
Nature Publishing Group
external identifiers
  • scopus:84964617583
  • wos:000374502000001
ISSN
2045-2322
DOI
10.1038/srep24818
language
English
LU publication?
yes
id
8edb0254-31c2-4c63-8741-718da3cfe8f9
date added to LUP
2016-09-30 13:40:34
date last changed
2017-10-29 04:52:19
@article{8edb0254-31c2-4c63-8741-718da3cfe8f9,
  abstract     = {<p>Optogenetics is one of the most powerful tools in neuroscience, allowing for selective control of specific neuronal populations in the brain of experimental animals, including mammals. We report, for the first time, the application of optogenetic tools to human brain tissue providing a proof-of-concept for the use of optogenetics in neuromodulation of human cortical and hippocampal neurons as a possible tool to explore network mechanisms and develop future therapeutic strategies.</p>},
  articleno    = {24818},
  author       = {Andersson, My and Avaliani, Natalia and Svensson, Andreas and Wickham, Jenny and Pinborg, Lars H. and Jespersen, Bo and Christiansen, Søren H. and Bengzon, Johan and Woldbye, David P D and Kokaia, Merab},
  issn         = {2045-2322},
  language     = {eng},
  month        = {04},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Optogenetic control of human neurons in organotypic brain cultures},
  url          = {http://dx.doi.org/10.1038/srep24818},
  volume       = {6},
  year         = {2016},
}