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Closed-loop Prevention of Hypotension in the Heartbeating Brain-dead Porcine Model

Soltesz, Kristian LU ; Sturk, Christopher LU ; Paskevicius, Audrius LU ; Liao, Qiuming LU ; Qin, Guangqi LU ; Sjöberg, Trygve LU and Steen, Stig LU (2016) In IEEE Transactions on Biomedical Engineering
Abstract
Objective: The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model.

Methods:
Dynamic modeling and system identification were based on in-vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. Results: The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous... (More)
Objective: The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model.

Methods:
Dynamic modeling and system identification were based on in-vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. Results: The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous operation.

Conclusion: Parameter variability in the identified models confirmed the benefit of closed-loop controlled administration of the proposed therapy. The evaluated robust controller was able to mitigate both process uncertainty and external disturbances.

Significance:
Prevention of hypertension is critical to the care of heartbeating brain-dead organ donors. Its automation would likely increase the fraction of organs suitable for transplantation from this patient group. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Drug delivery, Medical control systems
in
IEEE Transactions on Biomedical Engineering
issue
99
pages
8 pages
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
ISSN
0018-9294
DOI
10.1109/TBME.2016.2602228
language
English
LU publication?
yes
id
8eedfc3a-db98-460e-a110-eba027353d16
date added to LUP
2016-08-18 17:35:43
date last changed
2017-01-26 14:10:17
@article{8eedfc3a-db98-460e-a110-eba027353d16,
  abstract     = {<i>Objective:</i> The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model. <i><br/><br/>Methods:</i> Dynamic modeling and system identification were based on <i>in-vivo</i> data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated <i>in vivo</i>. <i>Results:</i> The control system responded both predictably and consistently to external disturbances. It was possible to prevent mean arterial pressure to fall below a user-specified reference throughout 24 h of completely autonomous operation.<br/><br/><i>Conclusion:</i> Parameter variability in the identified models confirmed the benefit of closed-loop controlled administration of the proposed therapy. The evaluated robust controller was able to mitigate both process uncertainty and external disturbances. <i><br/><br/>Significance:</i> Prevention of hypertension is critical to the care of heartbeating brain-dead organ donors. Its automation would likely increase the fraction of organs suitable for transplantation from this patient group.},
  author       = {Soltesz, Kristian and Sturk, Christopher and Paskevicius, Audrius and Liao, Qiuming and Qin, Guangqi and Sjöberg, Trygve and Steen, Stig},
  issn         = {0018-9294},
  keyword      = {Drug delivery, Medical control systems},
  language     = {eng},
  number       = {99},
  pages        = {8},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Biomedical Engineering},
  title        = {Closed-loop Prevention of Hypotension in the Heartbeating Brain-dead Porcine Model},
  url          = {http://dx.doi.org/10.1109/TBME.2016.2602228},
  year         = {2016},
}