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The associations of self-rated health with cardiovascular risk proteins : A proteomics approach

Bao, Xue LU ; Borné, Yan LU ; Yin, Songjiang LU ; Niu, Kaijun ; Orho-Melander, Marju LU ; Nilsson, Jan LU ; Melander, Olle LU orcid and Engström, Gunnar LU (2019) In Clinical Proteomics 16.
Abstract

Background: Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD. 

Methods: Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approach was used to assess the associations of SRH with 88 cardiovascular risk proteins, measured in plasma from 4521 participants without CVD. The false discovery rate (FDR) was controlled using the Benjamini and Hochberg method. Covariates taken into consideration were age, sex, traditional CVD risk factors (low-density lipoprotein... (More)

Background: Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD. 

Methods: Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approach was used to assess the associations of SRH with 88 cardiovascular risk proteins, measured in plasma from 4521 participants without CVD. The false discovery rate (FDR) was controlled using the Benjamini and Hochberg method. Covariates taken into consideration were age, sex, traditional CVD risk factors (low-density lipoprotein cholesterol, systolic blood pressure, anti-hypertensive medication, diabetes, body mass index, smoking), comorbidity, life-style and psycho-social factors (education level, living alone, alcohol consumption, low physical activity, psychiatric medication, sleep duration, and unemployment). 

Results: Age and sex-adjusted associations with SRH was found for 34 plasma proteins. Nine of them remained significant after adjustments for traditional CVD risk factors. After further adjustment for comorbidity, life-style and psycho-social factors, only leptin (β = - 0.035, corrected p = 0.016) and C-C motif chemokine 20 (CCL20; β = - 0.054, corrected p = 0.016) were significantly associated with SRH. 

Conclusions: Poor SRH was associated with raised concentrations of many plasma proteins. However, the relationships were largely attenuated by adjustments for CVD risk factors, comorbidity and psycho-social factors. Leptin and CCL20 were associated with poor SRH in the present study and could potentially be involved in the SRH-CVD link.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-C motif chemokine 20, Leptin, Proteomic, Self-rated health
in
Clinical Proteomics
volume
16
article number
40
publisher
Humana Press
external identifiers
  • pmid:31832026
  • scopus:85075617174
ISSN
1542-6416
DOI
10.1186/s12014-019-9258-9
language
English
LU publication?
yes
id
8f159b9a-e447-4064-acf9-c847653585db
date added to LUP
2019-12-18 12:07:55
date last changed
2024-05-01 02:43:11
@article{8f159b9a-e447-4064-acf9-c847653585db,
  abstract     = {{<p>Background: Though subjective, poor self-rated health (SRH) has consistently been shown to predict cardiovascular disease (CVD). The underlying mechanism is unclear. This study evaluates the associations of SRH with biomarkers for CVD, aiming to explore potential pathways between poor SRH and CVD. </p><p>Methods: Based on the Malmö Diet and Cancer Cardiovascular Cohort study, a targeted proteomics approach was used to assess the associations of SRH with 88 cardiovascular risk proteins, measured in plasma from 4521 participants without CVD. The false discovery rate (FDR) was controlled using the Benjamini and Hochberg method. Covariates taken into consideration were age, sex, traditional CVD risk factors (low-density lipoprotein cholesterol, systolic blood pressure, anti-hypertensive medication, diabetes, body mass index, smoking), comorbidity, life-style and psycho-social factors (education level, living alone, alcohol consumption, low physical activity, psychiatric medication, sleep duration, and unemployment). </p><p>Results: Age and sex-adjusted associations with SRH was found for 34 plasma proteins. Nine of them remained significant after adjustments for traditional CVD risk factors. After further adjustment for comorbidity, life-style and psycho-social factors, only leptin (β = - 0.035, corrected p = 0.016) and C-C motif chemokine 20 (CCL20; β = - 0.054, corrected p = 0.016) were significantly associated with SRH. </p><p>Conclusions: Poor SRH was associated with raised concentrations of many plasma proteins. However, the relationships were largely attenuated by adjustments for CVD risk factors, comorbidity and psycho-social factors. Leptin and CCL20 were associated with poor SRH in the present study and could potentially be involved in the SRH-CVD link.</p>}},
  author       = {{Bao, Xue and Borné, Yan and Yin, Songjiang and Niu, Kaijun and Orho-Melander, Marju and Nilsson, Jan and Melander, Olle and Engström, Gunnar}},
  issn         = {{1542-6416}},
  keywords     = {{C-C motif chemokine 20; Leptin; Proteomic; Self-rated health}},
  language     = {{eng}},
  month        = {{11}},
  publisher    = {{Humana Press}},
  series       = {{Clinical Proteomics}},
  title        = {{The associations of self-rated health with cardiovascular risk proteins : A proteomics approach}},
  url          = {{http://dx.doi.org/10.1186/s12014-019-9258-9}},
  doi          = {{10.1186/s12014-019-9258-9}},
  volume       = {{16}},
  year         = {{2019}},
}