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Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity.

Mattsson, Kristina LU ; Källén, Karin LU ; Longnecker, M P; Rignell-Hydbom, Anna LU and Rylander, Lars LU (2013) In Diabetologia 56(8). p.1689-1695
Abstract
AIMS/HYPOTHESIS: The primary aim of the study was to investigate the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes. METHODS: Data were retrieved from the Medical Birth Register of Sweden for women who were born in 1982 (when smoking data were first registered) or later and who had given birth to at least one child; 80,189 pregnancies were included. The associations between in utero smoking exposure (three categories: non-smokers, 1-9 cigarettes/day [moderately exposed] and >9 cigarettes/day [heavily exposed]) and subsequent gestational diabetes (n = 291), non-gestational diabetes (n = 280) and obesity (n = 7,300)... (More)
AIMS/HYPOTHESIS: The primary aim of the study was to investigate the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes. METHODS: Data were retrieved from the Medical Birth Register of Sweden for women who were born in 1982 (when smoking data were first registered) or later and who had given birth to at least one child; 80,189 pregnancies were included. The associations between in utero smoking exposure (three categories: non-smokers, 1-9 cigarettes/day [moderately exposed] and >9 cigarettes/day [heavily exposed]) and subsequent gestational diabetes (n = 291), non-gestational diabetes (n = 280) and obesity (n = 7,300) were assessed. RESULTS: The adjusted ORs (aORs) of gestational diabetes were increased among women who were moderately (1.62, 95% CI 1.24, 2.13) and heavily (1.52, 95% CI 1.12, 2.06) exposed. The corresponding aORs of obesity were 1.36 (95% CI 1.28, 1.44) and 1.58 (95% CI 1.48, 1.68), respectively. A reduced OR for non-gestational diabetes was seen in the offspring of heavy smokers (aOR 0.66, 95% CI 0.45, 0.96). CONCLUSIONS/INTERPRETATION: Women exposed to smoking during fetal life were at higher risk of developing gestational diabetes and obesity. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
56
issue
8
pages
1689 - 1695
publisher
Springer
external identifiers
  • wos:000321285400003
  • pmid:23699990
  • scopus:84879894505
ISSN
1432-0428
DOI
10.1007/s00125-013-2936-7
language
English
LU publication?
yes
id
8f3fe463-ac8d-4a7f-93b8-8d9c8f69bca8 (old id 3804246)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23699990?dopt=Abstract
date added to LUP
2013-06-06 21:03:25
date last changed
2019-04-23 01:33:37
@article{8f3fe463-ac8d-4a7f-93b8-8d9c8f69bca8,
  abstract     = {AIMS/HYPOTHESIS: The primary aim of the study was to investigate the risk of developing gestational diabetes in women who were exposed to tobacco smoke in utero. Secondary aims were to assess the risk of obesity and non-gestational diabetes. METHODS: Data were retrieved from the Medical Birth Register of Sweden for women who were born in 1982 (when smoking data were first registered) or later and who had given birth to at least one child; 80,189 pregnancies were included. The associations between in utero smoking exposure (three categories: non-smokers, 1-9 cigarettes/day [moderately exposed] and >9 cigarettes/day [heavily exposed]) and subsequent gestational diabetes (n = 291), non-gestational diabetes (n = 280) and obesity (n = 7,300) were assessed. RESULTS: The adjusted ORs (aORs) of gestational diabetes were increased among women who were moderately (1.62, 95% CI 1.24, 2.13) and heavily (1.52, 95% CI 1.12, 2.06) exposed. The corresponding aORs of obesity were 1.36 (95% CI 1.28, 1.44) and 1.58 (95% CI 1.48, 1.68), respectively. A reduced OR for non-gestational diabetes was seen in the offspring of heavy smokers (aOR 0.66, 95% CI 0.45, 0.96). CONCLUSIONS/INTERPRETATION: Women exposed to smoking during fetal life were at higher risk of developing gestational diabetes and obesity.},
  author       = {Mattsson, Kristina and Källén, Karin and Longnecker, M P and Rignell-Hydbom, Anna and Rylander, Lars},
  issn         = {1432-0428},
  language     = {eng},
  number       = {8},
  pages        = {1689--1695},
  publisher    = {Springer},
  series       = {Diabetologia},
  title        = {Maternal smoking during pregnancy and daughters' risk of gestational diabetes and obesity.},
  url          = {http://dx.doi.org/10.1007/s00125-013-2936-7},
  volume       = {56},
  year         = {2013},
}