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A numerical human brain phantom for dynamic glucose-enhanced (DGE) MRI : On the influence of head motion at 3T

Lehmann, Patrick M LU orcid ; Seidemo, Anina LU ; Andersen, Mads LU ; Xu, Xiang ; Li, Xu ; Yadav, Nirbhay N ; Wirestam, Ronnie LU orcid ; Liebig, Patrick ; Testud, Frederik LU and Sundgren, Pia LU orcid , et al. (2023) In Magnetic Resonance in Medicine 89(5). p.1871-1887
Abstract

PURPOSE: Dynamic glucose-enhanced (DGE) MRI relates to a group of exchange-based MRI techniques where the uptake of glucose analogues is studied dynamically. However, motion artifacts can be mistaken for true DGE effects, while motion correction may alter true signal effects. The aim was to design a numerical human brain phantom to simulate a realistic DGE MRI protocol at 3T that can be used to assess the influence of head movement on the signal before and after retrospective motion correction.

METHODS: MPRAGE data from a tumor patient were used to simulate dynamic Z-spectra under the influence of motion. The DGE responses for different tissue types were simulated, creating a ground truth. Rigid head movement patterns were applied... (More)

PURPOSE: Dynamic glucose-enhanced (DGE) MRI relates to a group of exchange-based MRI techniques where the uptake of glucose analogues is studied dynamically. However, motion artifacts can be mistaken for true DGE effects, while motion correction may alter true signal effects. The aim was to design a numerical human brain phantom to simulate a realistic DGE MRI protocol at 3T that can be used to assess the influence of head movement on the signal before and after retrospective motion correction.

METHODS: MPRAGE data from a tumor patient were used to simulate dynamic Z-spectra under the influence of motion. The DGE responses for different tissue types were simulated, creating a ground truth. Rigid head movement patterns were applied as well as physiological dilatation and pulsation of the lateral ventricles and head-motion-induced B 0 -changes in presence of first-order shimming. The effect of retrospective motion correction was evaluated.

RESULTS: Motion artifacts similar to those previously reported for in vivo DGE data could be reproduced. Head movement of 1 mm translation and 1.5 degrees rotation led to a pseudo-DGE effect on the order of 1% signal change. B 0 effects due to head motion altered DGE changes due to a shift in the water saturation spectrum. Pseudo DGE effects were partly reduced or enhanced by rigid motion correction depending on tissue location.

CONCLUSION: DGE MRI studies can be corrupted by motion artifacts. Designing post-processing methods using retrospective motion correction including B 0 correction will be crucial for clinical implementation. The proposed phantom should be useful for evaluation and optimization of such techniques.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CEST, D-glucose, dynamic glucose enhanced, glucoCEST, motion correction, simulations
in
Magnetic Resonance in Medicine
volume
89
issue
5
pages
17 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85145315833
  • pmid:36579955
ISSN
1522-2594
DOI
10.1002/mrm.29563
language
English
LU publication?
yes
additional info
© 2022 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
id
9054b510-f0cc-431d-ad26-a689e0b90fe8
date added to LUP
2023-01-02 14:55:49
date last changed
2024-04-18 17:28:14
@article{9054b510-f0cc-431d-ad26-a689e0b90fe8,
  abstract     = {{<p>PURPOSE: Dynamic glucose-enhanced (DGE) MRI relates to a group of exchange-based MRI techniques where the uptake of glucose analogues is studied dynamically. However, motion artifacts can be mistaken for true DGE effects, while motion correction may alter true signal effects. The aim was to design a numerical human brain phantom to simulate a realistic DGE MRI protocol at 3T that can be used to assess the influence of head movement on the signal before and after retrospective motion correction.</p><p>METHODS: MPRAGE data from a tumor patient were used to simulate dynamic Z-spectra under the influence of motion. The DGE responses for different tissue types were simulated, creating a ground truth. Rigid head movement patterns were applied as well as physiological dilatation and pulsation of the lateral ventricles and head-motion-induced B 0 -changes in presence of first-order shimming. The effect of retrospective motion correction was evaluated. </p><p>RESULTS: Motion artifacts similar to those previously reported for in vivo DGE data could be reproduced. Head movement of 1 mm translation and 1.5 degrees rotation led to a pseudo-DGE effect on the order of 1% signal change. B 0 effects due to head motion altered DGE changes due to a shift in the water saturation spectrum. Pseudo DGE effects were partly reduced or enhanced by rigid motion correction depending on tissue location. </p><p>CONCLUSION: DGE MRI studies can be corrupted by motion artifacts. Designing post-processing methods using retrospective motion correction including B 0 correction will be crucial for clinical implementation. The proposed phantom should be useful for evaluation and optimization of such techniques. </p>}},
  author       = {{Lehmann, Patrick M and Seidemo, Anina and Andersen, Mads and Xu, Xiang and Li, Xu and Yadav, Nirbhay N and Wirestam, Ronnie and Liebig, Patrick and Testud, Frederik and Sundgren, Pia and van Zijl, Peter C M and Knutsson, Linda}},
  issn         = {{1522-2594}},
  keywords     = {{CEST; D-glucose; dynamic glucose enhanced; glucoCEST; motion correction; simulations}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1871--1887}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Magnetic Resonance in Medicine}},
  title        = {{A numerical human brain phantom for dynamic glucose-enhanced (DGE) MRI : On the influence of head motion at 3T}},
  url          = {{http://dx.doi.org/10.1002/mrm.29563}},
  doi          = {{10.1002/mrm.29563}},
  volume       = {{89}},
  year         = {{2023}},
}