Advanced

Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition

Lin, Crystal; Travis, Ruth C.; Appleby, Paul N.; Tipper, Sarah; Weiderpass, Elisabete; Chang-Claude, Jenny; Gram, Inger T.; Kaaks, Rudolf; Kiemeney, Lambertus A. and Ljungberg, Börje, et al. (2018) In International Journal of Cancer 143(10). p.2351-2358
Abstract

Previous in vitro and case–control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between... (More)

Previous in vitro and case–control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66–1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65–1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bladder cancer, EPIC cohort, IGF-I, prospective, urothelial cell carcinoma
in
International Journal of Cancer
volume
143
issue
10
pages
8 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85053382965
ISSN
0020-7136
DOI
10.1002/ijc.31650
language
English
LU publication?
yes
id
90fc7ba3-4fe2-4be5-a253-3f70981da737
date added to LUP
2018-11-13 14:28:54
date last changed
2019-02-20 11:35:36
@article{90fc7ba3-4fe2-4be5-a253-3f70981da737,
  abstract     = {<p>Previous in vitro and case–control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66–1.24, p<sub>trend</sub> = 0.40) or UCC (n of cases = 776; 0.91, 0.65–1.26, p<sub>trend</sub> = 0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (p<sub>heterogeneity</sub> &gt; 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk.</p>},
  author       = {Lin, Crystal and Travis, Ruth C. and Appleby, Paul N. and Tipper, Sarah and Weiderpass, Elisabete and Chang-Claude, Jenny and Gram, Inger T. and Kaaks, Rudolf and Kiemeney, Lambertus A. and Ljungberg, Börje and Tumino, Rosario and Tjønneland, Anne and Roswall, Nina and Overvad, Kim and Boutron-Ruault, Marie Christine and Manciniveri, Francesca Romana and Severi, Gianluca and Trichopoulou, Antonia and Masala, Giovanna and Sacerdote, Carlotta and Agnoli, Claudia and Panico, Salvatore and Bueno-de-Mesquita, Bas and Peeters, Petra H. and Salamanca-Fernández, Elena and Chirlaque, Maria Dolores and Ardanaz, Eva and Dorronsoro, Miren and Menéndez, Virginia and Luján-Barroso, Leila and Liedberg, Fredrik and Freisling, Heinz and Gunter, Marc and Aune, Dagfinn and Cross, Amanda J. and Riboli, Elio and Key, Timothy J. and Perez-Cornago, Aurora},
  issn         = {0020-7136},
  keyword      = {bladder cancer,EPIC cohort,IGF-I,prospective,urothelial cell carcinoma},
  language     = {eng},
  month        = {11},
  number       = {10},
  pages        = {2351--2358},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.31650},
  volume       = {143},
  year         = {2018},
}