Advanced

Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial

Thorstensson, Carina LU ; Roos, Ewa LU ; Petersson, Ingemar LU and Ekdahl, Charlotte LU (2005) In BMC Musculoskeletal Disorders 6.
Abstract
Background: Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and definite radiographic knee osteoarthritis. The aim was to test the effects of a short-term, high-intensity exercise program on self-reported pain, function and quality of life. Methods: Patients aged 36 - 65, with OA grade III (Kellgren & Lawrence) were recruited. They had been referred for radiographic examination due to knee pain and had no history of major knee injury. They were randomized to a twice weekly supervised one hour exercise intervention for six weeks, or to a non-intervention control group. Exercise was performed at >= 60% of maximum heart rate (HR max). The primary... (More)
Background: Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and definite radiographic knee osteoarthritis. The aim was to test the effects of a short-term, high-intensity exercise program on self-reported pain, function and quality of life. Methods: Patients aged 36 - 65, with OA grade III (Kellgren & Lawrence) were recruited. They had been referred for radiographic examination due to knee pain and had no history of major knee injury. They were randomized to a twice weekly supervised one hour exercise intervention for six weeks, or to a non-intervention control group. Exercise was performed at >= 60% of maximum heart rate (HR max). The primary outcome measure was the Knee injury and Osteoarthritis Outcome Score (KOOS). Follow-up occurred at 6 weeks and 6 months. Results: Sixty-one subjects ( mean age 56 (SD 6), 51 % women, mean BMI 29.5 ( SD 4.8)) were randomly assigned to intervention ( n = 30) or control group ( n = 31). No significant differences in the KOOS subscales assessing pain, other symptoms, or function in daily life or in sport and recreation were seen at any time point between exercisers and controls. In the exercise group, an improvement was seen at 6 weeks in the KOOS subscale quality of life compared to the control group ( mean change 4.0 vs. - 0.7, p = 0.05). The difference between groups was still persistent at 6 months ( p = 0.02). Conclusion: A six-week high-intensive exercise program had no effect on pain or function in middle-aged patients with moderate to severe radiographic knee OA. Some effect was seen on quality of life in the exercise group compared to the control group. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Musculoskeletal Disorders
volume
6
publisher
BioMed Central
external identifiers
  • wos:000231267800001
  • pmid:15924620
  • scopus:23944441527
ISSN
1471-2474
DOI
10.1186/1471-2474-6-27
language
English
LU publication?
yes
id
48058c39-4558-4d89-8ce3-8b6f04d3002c (old id 910271)
date added to LUP
2008-01-21 12:02:35
date last changed
2017-10-29 04:18:09
@article{48058c39-4558-4d89-8ce3-8b6f04d3002c,
  abstract     = {Background: Studies on exercise in knee osteoarthritis (OA) have focused on elderly subjects. Subjects in this study were middle-aged with symptomatic and definite radiographic knee osteoarthritis. The aim was to test the effects of a short-term, high-intensity exercise program on self-reported pain, function and quality of life. Methods: Patients aged 36 - 65, with OA grade III (Kellgren & Lawrence) were recruited. They had been referred for radiographic examination due to knee pain and had no history of major knee injury. They were randomized to a twice weekly supervised one hour exercise intervention for six weeks, or to a non-intervention control group. Exercise was performed at >= 60% of maximum heart rate (HR max). The primary outcome measure was the Knee injury and Osteoarthritis Outcome Score (KOOS). Follow-up occurred at 6 weeks and 6 months. Results: Sixty-one subjects ( mean age 56 (SD 6), 51 % women, mean BMI 29.5 ( SD 4.8)) were randomly assigned to intervention ( n = 30) or control group ( n = 31). No significant differences in the KOOS subscales assessing pain, other symptoms, or function in daily life or in sport and recreation were seen at any time point between exercisers and controls. In the exercise group, an improvement was seen at 6 weeks in the KOOS subscale quality of life compared to the control group ( mean change 4.0 vs. - 0.7, p = 0.05). The difference between groups was still persistent at 6 months ( p = 0.02). Conclusion: A six-week high-intensive exercise program had no effect on pain or function in middle-aged patients with moderate to severe radiographic knee OA. Some effect was seen on quality of life in the exercise group compared to the control group.},
  author       = {Thorstensson, Carina and Roos, Ewa and Petersson, Ingemar and Ekdahl, Charlotte},
  issn         = {1471-2474},
  language     = {eng},
  publisher    = {BioMed Central},
  series       = {BMC Musculoskeletal Disorders},
  title        = {Six-week high-intensity exercise program for middle-aged patients with knee osteoarthritis: a randomized controlled trial},
  url          = {http://dx.doi.org/10.1186/1471-2474-6-27},
  volume       = {6},
  year         = {2005},
}