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Measures of lung function and their relationship with advanced glycation end-products

Zaigham, Suneela LU ; Persson, Margaretha LU orcid ; Jujic, Amra LU ; Frantz, Sophia LU ; Borné, Yan LU ; Malinovschi, Andrei ; Wollmer, Per LU and Engström, Gunnar LU (2020) In ERJ Open Research 6(2).
Abstract

Background: Advanced glycation end-products (AGEs) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the association between AGE accumulation in the skin measured by skin autofluorescence (SAF) and lung function in healthy subjects has not been explored in detail. We use a population-based study of 50-64-year-olds to assess spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) and impulse oscillometry (IOS) in relation to SAF.

Methods: Participants with information on SAF, lung function and potential confounding variables were included from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) cohort (spirometry, n=4111; DLCO, n=3889; IOS, n=3970). Linear regression... (More)

Background: Advanced glycation end-products (AGEs) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the association between AGE accumulation in the skin measured by skin autofluorescence (SAF) and lung function in healthy subjects has not been explored in detail. We use a population-based study of 50-64-year-olds to assess spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) and impulse oscillometry (IOS) in relation to SAF.

Methods: Participants with information on SAF, lung function and potential confounding variables were included from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) cohort (spirometry, n=4111; DLCO, n=3889; IOS, n=3970). Linear regression was used to assess changes in lung function (as measured by spirometry (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC), DLCO and IOS (resistance measured at 5 (R5) and 20 Hz (R20), R5-R20, area of reactance, reactance measured at 5 Hz (X-5), and resonant frequency)) by a 1-sd increase in SAF.

Results: FEV1, FVC and DLCO were significantly and inversely associated with SAF after adjustment for potential confounding factors (per 1-sd increase in SAF: FEV1 -0.03 L (95% CI -0.04- -0.02 L), p<0.001; FVC -0.03 L (95% CI -0.05- -0.02 L), p<0.001; DLCO -0.07 mmol·min-1·kPa-1 (95% CI -0.11- -0.03 mmol·min-1·kPa-1), p<0.001). This association was also found in nonsmokers and in non-COPD subjects. Pulmonary reactance (X5) but not pulmonary resistance (R5, R20 and R5-R20) was significantly associated with SAF (per 1-sd increase in SAF: X5 -0.001 kPa·L-1·s (95% CI -0.003-0.00 kPa·L-1·s), p=0.042), which was mirrored in non-COPD patients but not in current nonsmokers.

Conclusions: AGE accumulation, as measured by SAF, is significantly associated with lung function decrements indicative of changes in the lung parenchyma.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
ERJ Open Research
volume
6
issue
2
article number
00356-2019
publisher
European Respiratory Society
external identifiers
  • scopus:85114081198
  • pmid:32523964
ISSN
2312-0541
DOI
10.1183/23120541.00356-2019
language
English
LU publication?
yes
additional info
Copyright ©ERS 2020.
id
91b3cd55-8a1b-4b59-807f-c15fb500fa30
date added to LUP
2020-06-24 11:23:49
date last changed
2024-04-04 00:29:20
@article{91b3cd55-8a1b-4b59-807f-c15fb500fa30,
  abstract     = {{<p>Background: Advanced glycation end-products (AGEs) have been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the association between AGE accumulation in the skin measured by skin autofluorescence (SAF) and lung function in healthy subjects has not been explored in detail. We use a population-based study of 50-64-year-olds to assess spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) and impulse oscillometry (IOS) in relation to SAF.</p><p>Methods: Participants with information on SAF, lung function and potential confounding variables were included from the Swedish Cardiopulmonary Bioimage Study (SCAPIS) cohort (spirometry, n=4111; DLCO, n=3889; IOS, n=3970). Linear regression was used to assess changes in lung function (as measured by spirometry (forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC), DLCO and IOS (resistance measured at 5 (R5) and 20 Hz (R20), R5-R20, area of reactance, reactance measured at 5 Hz (X-5), and resonant frequency)) by a 1-sd increase in SAF.</p><p>Results: FEV1, FVC and DLCO were significantly and inversely associated with SAF after adjustment for potential confounding factors (per 1-sd increase in SAF: FEV1 -0.03 L (95% CI -0.04- -0.02 L), p&lt;0.001; FVC -0.03 L (95% CI -0.05- -0.02 L), p&lt;0.001; DLCO -0.07 mmol·min-1·kPa-1 (95% CI -0.11- -0.03 mmol·min-1·kPa-1), p&lt;0.001). This association was also found in nonsmokers and in non-COPD subjects. Pulmonary reactance (X5) but not pulmonary resistance (R5, R20 and R5-R20) was significantly associated with SAF (per 1-sd increase in SAF: X5 -0.001 kPa·L-1·s (95% CI -0.003-0.00 kPa·L-1·s), p=0.042), which was mirrored in non-COPD patients but not in current nonsmokers.</p><p>Conclusions: AGE accumulation, as measured by SAF, is significantly associated with lung function decrements indicative of changes in the lung parenchyma.</p>}},
  author       = {{Zaigham, Suneela and Persson, Margaretha and Jujic, Amra and Frantz, Sophia and Borné, Yan and Malinovschi, Andrei and Wollmer, Per and Engström, Gunnar}},
  issn         = {{2312-0541}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{European Respiratory Society}},
  series       = {{ERJ Open Research}},
  title        = {{Measures of lung function and their relationship with advanced glycation end-products}},
  url          = {{http://dx.doi.org/10.1183/23120541.00356-2019}},
  doi          = {{10.1183/23120541.00356-2019}},
  volume       = {{6}},
  year         = {{2020}},
}