Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease.
Sjöberg, Klas LU
; Eriksson, Sten
LU
; Tenngart, Birgitta
; Roth, Bodil
LU
; Leffler, Hakon
LU
and Stenberg, Pål
(2002)
In Autoimmunity
35(5).
p.357-364
- Abstract
- issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against... (More)
- issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may--when present--be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/112037
- author
- Sjöberg, Klas
LU
; Eriksson, Sten
LU
; Tenngart, Birgitta
; Roth, Bodil
LU
; Leffler, Hakon
LU
and Stenberg, Pål
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Autoimmunity, Coeliac Disease, Endomysial Antibodies, Factor Xiii, Transglutaminase Antibodies
- in
- Autoimmunity
- volume
- 35
- issue
- 5
- pages
- 357 - 364
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:12515290
- wos:000178871600008
- scopus:0036700633
- ISSN
- 0891-6934
- DOI
- 10.1080/0891693021000005402
- language
- English
- LU publication?
- yes
- id
- 9274ea3c-afd2-4287-8233-b156788941b5 (old id 112037)
- alternative location
- http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12515290&dopt=AbstractPlus
- date added to LUP
- 2016-04-01 17:09:52
- date last changed
- 2023-01-05 05:41:16
@article{9274ea3c-afd2-4287-8233-b156788941b5,
abstract = {{issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may--when present--be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease.}},
author = {{Sjöberg, Klas and Eriksson, Sten and Tenngart, Birgitta and Roth, Bodil and Leffler, Hakon and Stenberg, Pål}},
issn = {{0891-6934}},
keywords = {{Autoimmunity; Coeliac Disease; Endomysial Antibodies; Factor Xiii; Transglutaminase Antibodies}},
language = {{eng}},
number = {{5}},
pages = {{357--364}},
publisher = {{Taylor & Francis}},
series = {{Autoimmunity}},
title = {{Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease.}},
url = {{http://dx.doi.org/10.1080/0891693021000005402}},
doi = {{10.1080/0891693021000005402}},
volume = {{35}},
year = {{2002}},
}