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Aquaglyceroporins and orthodox aquaporins in human adipocytes

Huang, Peng LU ; Hansen, Jesper S. ; Saba, Karim H. LU orcid ; Bergman, Anna LU ; Negoita, Florentina LU ; Gourdon, Pontus LU ; Hagström-Andersson, Anna LU orcid and Lindkvist-Petersson, Karin LU (2022) In Biochimica et Biophysica Acta - Biomembranes 1864(1).
Abstract

Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we... (More)

Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we discovered by transcriptome sequencing that AQP1 is expressed in human primary adipocytes. AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia. Thus, this data suggests a contribution of both orthodox aquaporin and aquaglyceroporin in human adipocytes to maintain the homeostasis of glycerol and water during fasting and feeding.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AQP, Aquaglyceroporins, Human adipocytes, Orthodox aquaporins, Perilipin 1
in
Biochimica et Biophysica Acta - Biomembranes
volume
1864
issue
1
article number
183795
publisher
Elsevier
external identifiers
  • scopus:85116860294
  • pmid:34627746
ISSN
0005-2736
DOI
10.1016/j.bbamem.2021.183795
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 The Authors
id
928de913-b3be-4801-b4e2-985f4cda91b8
date added to LUP
2021-11-01 13:37:15
date last changed
2024-06-15 19:43:09
@article{928de913-b3be-4801-b4e2-985f4cda91b8,
  abstract     = {{<p>Aquaporins play a crucial role in water homeostasis in the human body, and recently the physiological importance of aquaporins as glycerol channels have been demonstrated. The aquaglyceroporins (AQP3, AQP7, AQP9 and AQP10) represent key glycerol channels, enabling glycerol flux across the membranes of cells. Adipocytes are the major source of glycerol and during lipolysis, glycerol is released to be metabolized by other tissues through a well-orchestrated process. Here we show that both AQP3 and AQP7 bind to the lipid droplet protein perilipin 1 (PLIN1), suggesting that PLIN1 is involved in the coordination of the subcellular translocation of aquaglyceroporins in human adipocytes. Moreover, in addition to aquaglyceroporins, we discovered by transcriptome sequencing that AQP1 is expressed in human primary adipocytes. AQP1 is mainly a water channel and thus is thought to be involved in the response to hyper-osmotic stress by efflux of water during hyperglycemia. Thus, this data suggests a contribution of both orthodox aquaporin and aquaglyceroporin in human adipocytes to maintain the homeostasis of glycerol and water during fasting and feeding.</p>}},
  author       = {{Huang, Peng and Hansen, Jesper S. and Saba, Karim H. and Bergman, Anna and Negoita, Florentina and Gourdon, Pontus and Hagström-Andersson, Anna and Lindkvist-Petersson, Karin}},
  issn         = {{0005-2736}},
  keywords     = {{AQP; Aquaglyceroporins; Human adipocytes; Orthodox aquaporins; Perilipin 1}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{1}},
  publisher    = {{Elsevier}},
  series       = {{Biochimica et Biophysica Acta - Biomembranes}},
  title        = {{Aquaglyceroporins and orthodox aquaporins in human adipocytes}},
  url          = {{http://dx.doi.org/10.1016/j.bbamem.2021.183795}},
  doi          = {{10.1016/j.bbamem.2021.183795}},
  volume       = {{1864}},
  year         = {{2022}},
}