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Measurement of intact parathyroid hormone in the diagnosis of hyperparathyroidism

Bergenfelz, A LU ; Valdermarsson, S and Ahrén, B LU (1991) In Acta Endocrinologica 125(6). p.74-668
Abstract

Plasma levels of parathyroid hormone were determined pre-operatively in 27 consecutive patients with clinical and biochemical signs of primary hyperparathyroidism, by the use of one assay recognizing the intact PTH molecule and one assay recognizing the mid-portion of PTH. Plasma levels of mid-molecule PTH were normal in 5 of the patients with primary hyperparathyroidism. In 4 of these patients, plasma levels of intact PTH were raised. Conversely, in 6 patients with primary hyperparathyroidism, intact PTH were normal pre-operatively. In 5 of these cases, plasma levels of mid-molecule PTH were raised. The EDTA infusion test was performed in 6 patients with normal baseline plasma level of intact PTH pre-operatively. The test correctly... (More)

Plasma levels of parathyroid hormone were determined pre-operatively in 27 consecutive patients with clinical and biochemical signs of primary hyperparathyroidism, by the use of one assay recognizing the intact PTH molecule and one assay recognizing the mid-portion of PTH. Plasma levels of mid-molecule PTH were normal in 5 of the patients with primary hyperparathyroidism. In 4 of these patients, plasma levels of intact PTH were raised. Conversely, in 6 patients with primary hyperparathyroidism, intact PTH were normal pre-operatively. In 5 of these cases, plasma levels of mid-molecule PTH were raised. The EDTA infusion test was performed in 6 patients with normal baseline plasma level of intact PTH pre-operatively. The test correctly predicted all the patients in this group who were found to have primary hyperparathyroidism, as well as a patient with normal parathyroid glands found at operation. We conclude that some patients with primary hyperparathyroidism have normal baseline plasma levels of intact PTH. In these patients, plasma levels of mid-molecule PTH and an EDTA infusion test provide further diagnostic information.

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published
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keywords
Adult, Aged, Aged, 80 and over, Biomarkers, Edetic Acid, Female, Humans, Hyperparathyroidism, Infusions, Intravenous, Male, Middle Aged, Parathyroid Hormone, Journal Article
in
Acta Endocrinologica
volume
125
issue
6
pages
74 - 668
publisher
Scandinavian University Press
external identifiers
  • scopus:0026344278
ISSN
0001-5598
language
English
LU publication?
yes
id
9295cb67-2185-4ac5-bcf8-6137080dd14d
date added to LUP
2017-05-10 13:46:28
date last changed
2017-09-20 15:29:07
@article{9295cb67-2185-4ac5-bcf8-6137080dd14d,
  abstract     = {<p>Plasma levels of parathyroid hormone were determined pre-operatively in 27 consecutive patients with clinical and biochemical signs of primary hyperparathyroidism, by the use of one assay recognizing the intact PTH molecule and one assay recognizing the mid-portion of PTH. Plasma levels of mid-molecule PTH were normal in 5 of the patients with primary hyperparathyroidism. In 4 of these patients, plasma levels of intact PTH were raised. Conversely, in 6 patients with primary hyperparathyroidism, intact PTH were normal pre-operatively. In 5 of these cases, plasma levels of mid-molecule PTH were raised. The EDTA infusion test was performed in 6 patients with normal baseline plasma level of intact PTH pre-operatively. The test correctly predicted all the patients in this group who were found to have primary hyperparathyroidism, as well as a patient with normal parathyroid glands found at operation. We conclude that some patients with primary hyperparathyroidism have normal baseline plasma levels of intact PTH. In these patients, plasma levels of mid-molecule PTH and an EDTA infusion test provide further diagnostic information.</p>},
  author       = {Bergenfelz, A and Valdermarsson, S and Ahrén, B},
  issn         = {0001-5598},
  keyword      = {Adult,Aged,Aged, 80 and over,Biomarkers,Edetic Acid,Female,Humans,Hyperparathyroidism,Infusions, Intravenous,Male,Middle Aged,Parathyroid Hormone,Journal Article},
  language     = {eng},
  number       = {6},
  pages        = {74--668},
  publisher    = {Scandinavian University Press},
  series       = {Acta Endocrinologica},
  title        = {Measurement of intact parathyroid hormone in the diagnosis of hyperparathyroidism},
  volume       = {125},
  year         = {1991},
}