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Butler enables rapid cloud-based analysis of thousands of human genomes

Yakneen, Sergei ; Waszak, Sebastian M ; Gertz, Michael and Korbel, Jan O (2020) In Nature Biotechnology 38(3). p.288-292
Abstract

We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

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author
; ; and
contributor
LU ; LU orcid and LU orcid
author collaboration
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cloud Computing, Computational Biology/methods, Genome, Human, Humans, Neoplasms/genetics, Software
in
Nature Biotechnology
volume
38
issue
3
pages
288 - 292
publisher
Nature Publishing Group
external identifiers
  • pmid:32024987
  • scopus:85079041410
ISSN
1546-1696
DOI
10.1038/s41587-019-0360-3
language
English
LU publication?
yes
id
937aa1b1-6488-4110-90c0-09f638a5ec5a
date added to LUP
2023-03-29 17:26:07
date last changed
2024-10-04 12:43:21
@article{937aa1b1-6488-4110-90c0-09f638a5ec5a,
  abstract     = {{<p>We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.</p>}},
  author       = {{Yakneen, Sergei and Waszak, Sebastian M and Gertz, Michael and Korbel, Jan O}},
  issn         = {{1546-1696}},
  keywords     = {{Cloud Computing; Computational Biology/methods; Genome, Human; Humans; Neoplasms/genetics; Software}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{288--292}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Biotechnology}},
  title        = {{Butler enables rapid cloud-based analysis of thousands of human genomes}},
  url          = {{http://dx.doi.org/10.1038/s41587-019-0360-3}},
  doi          = {{10.1038/s41587-019-0360-3}},
  volume       = {{38}},
  year         = {{2020}},
}