A Population-Based Study on the Incidence, Risk Factors, and Outcome of Salmonella Bloodstream Infections in South Sweden 2012–2022
Björklund, L. ; Mattisson, Y. LU ; Bläckberg, A. LU ; Sunnerhagen, T. LU
and Ljungquist, O.
LU
(2024)
In Infectious Diseases and Therapy
p.501-519
- Abstract
- Introduction
Invasive infections caused by Salmonella are a significant global health concern. This population-based study aimed to comprehensively analyze invasive Salmonella infections in South Sweden, focusing on incidence, clinical presentation, risk factors, and outcomes.
Methods
This population-based observational cohort study, conducted from 2012 to 2022, included all patients with Salmonella bloodstream infections (BSI) in the Skåne region, South Sweden. A control group consisted of patients with positive stool cultures/PCR for Salmonella but without BSI. Data were collected following a predefined study protocol from medical records. Standardized statistical analyses assessed patient characteristics, clinical... (More) - Introduction
Invasive infections caused by Salmonella are a significant global health concern. This population-based study aimed to comprehensively analyze invasive Salmonella infections in South Sweden, focusing on incidence, clinical presentation, risk factors, and outcomes.
Methods
This population-based observational cohort study, conducted from 2012 to 2022, included all patients with Salmonella bloodstream infections (BSI) in the Skåne region, South Sweden. A control group consisted of patients with positive stool cultures/PCR for Salmonella but without BSI. Data were collected following a predefined study protocol from medical records. Standardized statistical analyses assessed patient characteristics, clinical presentation, and outcomes.
Results
Between 2012 and 2022, 149 patients with SBSI were identified, with the majority having non-typhoidal Salmonella (NTS) infections (95%). A declining trend in the incidence of SBSI was observed, with the highest incidence in 2012 (1.5 per 100,000 person-years) and the lowest in 2020 (0.3 per 100,000 person-years). Patients with BSI were more likely to be older, have comorbidities, be immunosuppressed, and use proton pump inhibitors (PPIs). Additionally, patients with BSI presented with fewer gastrointestinal symptoms, had a higher respiratory rate, lower saturation, and higher SOFA scores, suggesting a more septic presentation. Patients with SBSI had significantly longer hospital stays and higher 30-day, 90-day, 180-day, and 365-day mortality rates compared to the control group.
Conclusion
Invasive Salmonella infections are rare in South Sweden. In a cohort of enteric and invasive Salmonella infection, the absence of classic gastroenteritis symptoms increases the risk of Salmonella bloodstream infection. This study highlights the importance of distinguishing between clinical presentations to guide appropriate treatment when Salmonella infection is suspected. The declining trend in incidence, particularly associated with international travel, necessitates further investigation to understand contributing factors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/93f30e7c-e382-4827-90ee-931c273541ea
- author
- Björklund, L.
; Mattisson, Y.
LU
; Bläckberg, A.
LU
; Sunnerhagen, T.
LU
and Ljungquist, O.
LU
- organization
- publishing date
- 2024-02-23
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Infectious Diseases and Therapy
- pages
- 501 - 519
- publisher
- Springer
- external identifiers
-
- pmid:38393503
- scopus:85187241594
- ISSN
- 2193-8229
- DOI
- 10.1007/s40121-024-00929-y
- project
- Invasive infections with gastrointestinal pathogens
- language
- English
- LU publication?
- yes
- id
- 93f30e7c-e382-4827-90ee-931c273541ea
- date added to LUP
- 2024-02-23 09:13:46
- date last changed
- 2024-04-09 13:57:59
@article{93f30e7c-e382-4827-90ee-931c273541ea,
abstract = {{Introduction<br/>Invasive infections caused by Salmonella are a significant global health concern. This population-based study aimed to comprehensively analyze invasive Salmonella infections in South Sweden, focusing on incidence, clinical presentation, risk factors, and outcomes.<br/><br/>Methods<br/>This population-based observational cohort study, conducted from 2012 to 2022, included all patients with Salmonella bloodstream infections (BSI) in the Skåne region, South Sweden. A control group consisted of patients with positive stool cultures/PCR for Salmonella but without BSI. Data were collected following a predefined study protocol from medical records. Standardized statistical analyses assessed patient characteristics, clinical presentation, and outcomes.<br/><br/>Results<br/>Between 2012 and 2022, 149 patients with SBSI were identified, with the majority having non-typhoidal Salmonella (NTS) infections (95%). A declining trend in the incidence of SBSI was observed, with the highest incidence in 2012 (1.5 per 100,000 person-years) and the lowest in 2020 (0.3 per 100,000 person-years). Patients with BSI were more likely to be older, have comorbidities, be immunosuppressed, and use proton pump inhibitors (PPIs). Additionally, patients with BSI presented with fewer gastrointestinal symptoms, had a higher respiratory rate, lower saturation, and higher SOFA scores, suggesting a more septic presentation. Patients with SBSI had significantly longer hospital stays and higher 30-day, 90-day, 180-day, and 365-day mortality rates compared to the control group.<br/><br/>Conclusion<br/>Invasive Salmonella infections are rare in South Sweden. In a cohort of enteric and invasive Salmonella infection, the absence of classic gastroenteritis symptoms increases the risk of Salmonella bloodstream infection. This study highlights the importance of distinguishing between clinical presentations to guide appropriate treatment when Salmonella infection is suspected. The declining trend in incidence, particularly associated with international travel, necessitates further investigation to understand contributing factors.}},
author = {{Björklund, L. and Mattisson, Y. and Bläckberg, A. and Sunnerhagen, T. and Ljungquist, O.}},
issn = {{2193-8229}},
language = {{eng}},
month = {{02}},
pages = {{501--519}},
publisher = {{Springer}},
series = {{Infectious Diseases and Therapy}},
title = {{A Population-Based Study on the Incidence, Risk Factors, and Outcome of Salmonella Bloodstream Infections in South Sweden 2012–2022}},
url = {{https://lup.lub.lu.se/search/files/172577117/s40121-024-00929-y.pdf}},
doi = {{10.1007/s40121-024-00929-y}},
year = {{2024}},
}