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Clinical translation of a novel photoacoustic imaging system for examining the temporal artery

Sheikh, Rafi LU ; Cinthio, Magnus LU ; Dahlstrand, Ulf LU ; Erlov, Tobias LU ; Naumovska, Magdalena LU ; Hammar, Bjorn LU ; Zackrisson, Sophia LU ; Jansson, Tomas LU ; Reistad, Nina LU and Malmsjo, Malin LU (2018) In IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Abstract

The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant cell arteritis (GCA), both in vivo and ex vivo, and the results were compared to that of histology. To adapt PAI to human studies, the transducer was fixed to an adjustable arm to reduce motion artifacts and a stepping motor was developed to enable 3D scanning. Risks associated with the use of lasers, ultrasound, and electrical equipment were evaluated by measuring energy levels, and safety precautions were undertaken to prevent injury to the patients and staff. The PAI spectra obtained... (More)

The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant cell arteritis (GCA), both in vivo and ex vivo, and the results were compared to that of histology. To adapt PAI to human studies, the transducer was fixed to an adjustable arm to reduce motion artifacts and a stepping motor was developed to enable 3D scanning. Risks associated with the use of lasers, ultrasound, and electrical equipment were evaluated by measuring energy levels, and safety precautions were undertaken to prevent injury to the patients and staff. The PAI spectra obtained clearly delineated the artery wall, both in vivo and ex vivo, although the latter were of higher quality due to the lack of artifacts. The results could be compared to that of histology. The energy levels involved were found to be below limits given in regulatory standards. Eye protectors prevented irradiation of the patient’s eyes, and visual function after the procedure was found not to be affected. The patients reported no discomfort during the investigations. PAI provides images of the temporal artery wall that may be used for the future diagnosis of GCA in humans. The technique could be further refined by addressing the specific problems of motion artefacts and interference from blood and other chromophores. This study paves the way for other clinical applications of PAI.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Arteries, Artery, Biopsy, Imaging, In vivo, Medical diagnostic imaging, Photoacoustic imaging, Temporal arteritis, Three-dimensional displays, Transducers, Ultrasonic imaging
in
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
publisher
IEEE--Institute of Electrical and Electronics Engineers Inc.
external identifiers
  • scopus:85053359530
ISSN
0885-3010
DOI
10.1109/TUFFC.2018.2868674
language
English
LU publication?
yes
id
944ea29a-7c4b-4e57-b442-1b0f850a6996
date added to LUP
2018-10-08 12:42:57
date last changed
2018-10-11 09:53:34
@article{944ea29a-7c4b-4e57-b442-1b0f850a6996,
  abstract     = {<p>The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant cell arteritis (GCA), both in vivo and ex vivo, and the results were compared to that of histology. To adapt PAI to human studies, the transducer was fixed to an adjustable arm to reduce motion artifacts and a stepping motor was developed to enable 3D scanning. Risks associated with the use of lasers, ultrasound, and electrical equipment were evaluated by measuring energy levels, and safety precautions were undertaken to prevent injury to the patients and staff. The PAI spectra obtained clearly delineated the artery wall, both in vivo and ex vivo, although the latter were of higher quality due to the lack of artifacts. The results could be compared to that of histology. The energy levels involved were found to be below limits given in regulatory standards. Eye protectors prevented irradiation of the patient&amp;#x2019;s eyes, and visual function after the procedure was found not to be affected. The patients reported no discomfort during the investigations. PAI provides images of the temporal artery wall that may be used for the future diagnosis of GCA in humans. The technique could be further refined by addressing the specific problems of motion artefacts and interference from blood and other chromophores. This study paves the way for other clinical applications of PAI.</p>},
  author       = {Sheikh, Rafi and Cinthio, Magnus and Dahlstrand, Ulf and Erlov, Tobias and Naumovska, Magdalena and Hammar, Bjorn and Zackrisson, Sophia and Jansson, Tomas and Reistad, Nina and Malmsjo, Malin},
  issn         = {0885-3010},
  keyword      = {Arteries,Artery,Biopsy,Imaging,In vivo,Medical diagnostic imaging,Photoacoustic imaging,Temporal arteritis,Three-dimensional displays,Transducers,Ultrasonic imaging},
  language     = {eng},
  month        = {09},
  publisher    = {IEEE--Institute of Electrical and Electronics Engineers Inc.},
  series       = {IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control},
  title        = {Clinical translation of a novel photoacoustic imaging system for examining the temporal artery},
  url          = {http://dx.doi.org/10.1109/TUFFC.2018.2868674},
  year         = {2018},
}