Clinical translation of a novel photoacoustic imaging system for examining the temporal artery
(2019) In IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control 66(3). p.472-480- Abstract
The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant cell arteritis (GCA), both in vivo and ex vivo, and the results were compared to that of histology. To adapt PAI to human studies, the transducer was fixed to an adjustable arm to reduce motion artifacts and a stepping motor was developed to enable 3D scanning. Risks associated with the use of lasers, ultrasound, and electrical equipment were evaluated by measuring energy levels, and safety precautions were undertaken to prevent injury to the patients and staff. The PAI spectra obtained... (More)
The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant cell arteritis (GCA), both in vivo and ex vivo, and the results were compared to that of histology. To adapt PAI to human studies, the transducer was fixed to an adjustable arm to reduce motion artifacts and a stepping motor was developed to enable 3D scanning. Risks associated with the use of lasers, ultrasound, and electrical equipment were evaluated by measuring energy levels, and safety precautions were undertaken to prevent injury to the patients and staff. The PAI spectra obtained clearly delineated the artery wall, both in vivo and ex vivo, although the latter were of higher quality due to the lack of artifacts. The results could be compared to that of histology. The energy levels involved were found to be below limits given in regulatory standards. Eye protectors prevented irradiation of the patient’s eyes, and visual function after the procedure was found not to be affected. The patients reported no discomfort during the investigations. PAI provides images of the temporal artery wall that may be used for the future diagnosis of GCA in humans. The technique could be further refined by addressing the specific problems of motion artefacts and interference from blood and other chromophores. This study paves the way for other clinical applications of PAI.
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- author
- Sheikh, Rafi LU ; Cinthio, Magnus LU ; Dahlstrand, Ulf LU ; Erlov, Tobias LU ; Naumovska, Magdalena LU ; Hammar, Bjorn LU ; Zackrisson, Sophia LU ; Jansson, Tomas LU ; Reistad, Nina LU and Malmsjo, Malin LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Arteries, Artery, Biopsy, Imaging, In vivo, Medical diagnostic imaging, Photoacoustic imaging, Temporal arteritis, Three-dimensional displays, Transducers, Ultrasonic imaging
- in
- IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control
- volume
- 66
- issue
- 3
- pages
- 472 - 480
- publisher
- IEEE - Institute of Electrical and Electronics Engineers Inc.
- external identifiers
-
- scopus:85053359530
- pmid:30872212
- ISSN
- 0885-3010
- DOI
- 10.1109/TUFFC.2018.2868674
- language
- English
- LU publication?
- yes
- id
- 944ea29a-7c4b-4e57-b442-1b0f850a6996
- date added to LUP
- 2018-10-08 12:42:57
- date last changed
- 2024-09-17 03:39:05
@article{944ea29a-7c4b-4e57-b442-1b0f850a6996, abstract = {{<p>The objective was to provide a clinical setup for photoacoustic imaging (PAI) of the temporal artery in humans and to describe the challenges encountered and methods of overcoming them. The temporal artery was examined in 7 patients with suspect giant cell arteritis (GCA), both in vivo and ex vivo, and the results were compared to that of histology. To adapt PAI to human studies, the transducer was fixed to an adjustable arm to reduce motion artifacts and a stepping motor was developed to enable 3D scanning. Risks associated with the use of lasers, ultrasound, and electrical equipment were evaluated by measuring energy levels, and safety precautions were undertaken to prevent injury to the patients and staff. The PAI spectra obtained clearly delineated the artery wall, both in vivo and ex vivo, although the latter were of higher quality due to the lack of artifacts. The results could be compared to that of histology. The energy levels involved were found to be below limits given in regulatory standards. Eye protectors prevented irradiation of the patient&#x2019;s eyes, and visual function after the procedure was found not to be affected. The patients reported no discomfort during the investigations. PAI provides images of the temporal artery wall that may be used for the future diagnosis of GCA in humans. The technique could be further refined by addressing the specific problems of motion artefacts and interference from blood and other chromophores. This study paves the way for other clinical applications of PAI.</p>}}, author = {{Sheikh, Rafi and Cinthio, Magnus and Dahlstrand, Ulf and Erlov, Tobias and Naumovska, Magdalena and Hammar, Bjorn and Zackrisson, Sophia and Jansson, Tomas and Reistad, Nina and Malmsjo, Malin}}, issn = {{0885-3010}}, keywords = {{Arteries; Artery; Biopsy; Imaging; In vivo; Medical diagnostic imaging; Photoacoustic imaging; Temporal arteritis; Three-dimensional displays; Transducers; Ultrasonic imaging}}, language = {{eng}}, number = {{3}}, pages = {{472--480}}, publisher = {{IEEE - Institute of Electrical and Electronics Engineers Inc.}}, series = {{IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control}}, title = {{Clinical translation of a novel photoacoustic imaging system for examining the temporal artery}}, url = {{http://dx.doi.org/10.1109/TUFFC.2018.2868674}}, doi = {{10.1109/TUFFC.2018.2868674}}, volume = {{66}}, year = {{2019}}, }