Dependence of macrophage superoxide release on the pulse amplitude of an applied pressure regime : A potential factor at the soft tissue-implant interface
(2016) In Journal of Tissue Engineering and Regenerative Medicine 10(3). p.227-238- Abstract
Failure of soft tissue implants has been largely attributed to the influence of biomaterial surface properties on the foreign body response, but some implant complications, e.g. macrophage accumulation and necrosis, are still not effectively addressed with surface treatments to minimize deleterious biomaterial effects. We explored an alternative explanation for implant failure, linking biocompatibility with implant micromotion-induced pressure fluctuations at the tissue-biomaterial interface. For this purpose, we used a custom in vitro system to characterize the effects of pressure fluctuations on the activity of macrophages, the predominant cells at a healing implant site. Initially, we quantified superoxide production by HL60-derived... (More)
Failure of soft tissue implants has been largely attributed to the influence of biomaterial surface properties on the foreign body response, but some implant complications, e.g. macrophage accumulation and necrosis, are still not effectively addressed with surface treatments to minimize deleterious biomaterial effects. We explored an alternative explanation for implant failure, linking biocompatibility with implant micromotion-induced pressure fluctuations at the tissue-biomaterial interface. For this purpose, we used a custom in vitro system to characterize the effects of pressure fluctuations on the activity of macrophages, the predominant cells at a healing implant site. Initially, we quantified superoxide production by HL60-derived macrophage-like cells under several different pressure regimes with means of 5-40 mmHg, amplitudes of 0-15 mmHg and frequencies of 0-1.5 Hz. All pressure regimes tested elicited significantly (p2=0.74; p
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- author
- Shin, Hainsworth Y. ; Frechette, Danielle M. ; Rohner, Nathan ; Zhang, Xiaoyan ; Puleo, David A. and Bjursten, Lars M. LU
- organization
- publishing date
- 2016-03-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cell adhesion, Macrophage, Mechanotransduction, Pressure, Superoxide, Tissue-implant interface
- in
- Journal of Tissue Engineering and Regenerative Medicine
- volume
- 10
- issue
- 3
- pages
- 227 - 238
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000372920000008
- pmid:23881832
- scopus:84961207254
- ISSN
- 1932-6254
- DOI
- 10.1002/term.1789
- language
- English
- LU publication?
- yes
- id
- 94514036-2370-44b1-a6e5-5b85712828fe
- date added to LUP
- 2016-05-18 16:40:06
- date last changed
- 2024-03-06 23:24:22
@article{94514036-2370-44b1-a6e5-5b85712828fe, abstract = {{<p>Failure of soft tissue implants has been largely attributed to the influence of biomaterial surface properties on the foreign body response, but some implant complications, e.g. macrophage accumulation and necrosis, are still not effectively addressed with surface treatments to minimize deleterious biomaterial effects. We explored an alternative explanation for implant failure, linking biocompatibility with implant micromotion-induced pressure fluctuations at the tissue-biomaterial interface. For this purpose, we used a custom in vitro system to characterize the effects of pressure fluctuations on the activity of macrophages, the predominant cells at a healing implant site. Initially, we quantified superoxide production by HL60-derived macrophage-like cells under several different pressure regimes with means of 5-40 mmHg, amplitudes of 0-15 mmHg and frequencies of 0-1.5 Hz. All pressure regimes tested elicited significantly (p2=0.74; p</p>}}, author = {{Shin, Hainsworth Y. and Frechette, Danielle M. and Rohner, Nathan and Zhang, Xiaoyan and Puleo, David A. and Bjursten, Lars M.}}, issn = {{1932-6254}}, keywords = {{Cell adhesion; Macrophage; Mechanotransduction; Pressure; Superoxide; Tissue-implant interface}}, language = {{eng}}, month = {{03}}, number = {{3}}, pages = {{227--238}}, publisher = {{John Wiley & Sons Inc.}}, series = {{Journal of Tissue Engineering and Regenerative Medicine}}, title = {{Dependence of macrophage superoxide release on the pulse amplitude of an applied pressure regime : A potential factor at the soft tissue-implant interface}}, url = {{http://dx.doi.org/10.1002/term.1789}}, doi = {{10.1002/term.1789}}, volume = {{10}}, year = {{2016}}, }