c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.
(2015) In Nature Reviews. Microbiology 13(12). p.749-760- Abstract
- The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator... (More)
- The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8148385
- author
- Bush, Matthew J ; Tschowri, Natalia ; Schlimpert, Susan ; Flärdh, Klas LU and Buttner, Mark J
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Reviews. Microbiology
- volume
- 13
- issue
- 12
- pages
- 749 - 760
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:26499894
- wos:000365839200005
- scopus:84947486837
- pmid:26499894
- ISSN
- 1740-1534
- DOI
- 10.1038/nrmicro3546
- language
- English
- LU publication?
- yes
- id
- 9530e159-9d6d-44b3-bdd8-6c9987df3a9f (old id 8148385)
- date added to LUP
- 2016-04-01 11:17:22
- date last changed
- 2022-04-28 08:45:40
@article{9530e159-9d6d-44b3-bdd8-6c9987df3a9f,
abstract = {{The complex life cycle of streptomycetes involves two distinct filamentous cell forms: the growing (or vegetative) hyphae and the reproductive (or aerial) hyphae, which differentiate into long chains of spores. Until recently, little was known about the signalling pathways that regulate the developmental transitions leading to sporulation. In this Review, we discuss important new insights into these pathways that have led to the emergence of a coherent regulatory network, focusing on the erection of aerial hyphae and the synchronous cell division event that produces dozens of unigenomic spores. In particular, we highlight the role of cyclic di-GMP (c-di-GMP) in controlling the initiation of development, and the role of the master regulator BldD in mediating c-di-GMP signalling.}},
author = {{Bush, Matthew J and Tschowri, Natalia and Schlimpert, Susan and Flärdh, Klas and Buttner, Mark J}},
issn = {{1740-1534}},
language = {{eng}},
number = {{12}},
pages = {{749--760}},
publisher = {{Nature Publishing Group}},
series = {{Nature Reviews. Microbiology}},
title = {{c-di-GMP signalling and the regulation of developmental transitions in streptomycetes.}},
url = {{http://dx.doi.org/10.1038/nrmicro3546}},
doi = {{10.1038/nrmicro3546}},
volume = {{13}},
year = {{2015}},
}