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Complement deficiencies and systemic lupus erythematosus

Truedsson, Lennart LU ; Bengtsson, Anders LU and Sturfelt, Gunnar LU (2007) In Autoimmunity 40(8). p.560-566
Abstract
The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencies and SLE could be explained by several mechanisms, including impaired clearance of immune complexes and impaired handling of apoptotic cells, aberrant tolerance induction or changes in cytokine regulation. Also during SLE disease flares, the complement system is activated giving rise to partial deficiency or dysfunction due to consumption. On the other hand, complement also takes part in the inflammatory reaction in the... (More)
The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencies and SLE could be explained by several mechanisms, including impaired clearance of immune complexes and impaired handling of apoptotic cells, aberrant tolerance induction or changes in cytokine regulation. Also during SLE disease flares, the complement system is activated giving rise to partial deficiency or dysfunction due to consumption. On the other hand, complement also takes part in the inflammatory reaction in the disease that gives rise to the tissue and organ damage. In this review various aspects of the relation between complement and SLE are discussed. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
complement, SLE, deficiency, autoimmune disease
in
Autoimmunity
volume
40
issue
8
pages
560 - 566
publisher
Taylor & Francis
external identifiers
  • wos:000251606200003
  • scopus:37349066319
ISSN
0891-6934
DOI
10.1080/08916930701510673
language
English
LU publication?
yes
id
001c6445-ddd6-45ef-a216-51710d98115e (old id 966180)
date added to LUP
2008-01-30 09:31:01
date last changed
2017-11-05 04:23:43
@article{001c6445-ddd6-45ef-a216-51710d98115e,
  abstract     = {The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencies and SLE could be explained by several mechanisms, including impaired clearance of immune complexes and impaired handling of apoptotic cells, aberrant tolerance induction or changes in cytokine regulation. Also during SLE disease flares, the complement system is activated giving rise to partial deficiency or dysfunction due to consumption. On the other hand, complement also takes part in the inflammatory reaction in the disease that gives rise to the tissue and organ damage. In this review various aspects of the relation between complement and SLE are discussed.},
  author       = {Truedsson, Lennart and Bengtsson, Anders and Sturfelt, Gunnar},
  issn         = {0891-6934},
  keyword      = {complement,SLE,deficiency,autoimmune disease},
  language     = {eng},
  number       = {8},
  pages        = {560--566},
  publisher    = {Taylor & Francis},
  series       = {Autoimmunity},
  title        = {Complement deficiencies and systemic lupus erythematosus},
  url          = {http://dx.doi.org/10.1080/08916930701510673},
  volume       = {40},
  year         = {2007},
}