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Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography

Axelsson, Johan LU ; Svensson, Jenny LU and Andersson-Engels, Stefan LU (2007) In Optics Express 15(21). p.13574-13584
Abstract
Fluorescence molecular tomography suffers from being mathematically ill-conditioned resulting in non-unique solutions to the reconstruction problem. In an attempt to reduce the number of possible solutions in the underdetermined system of equations in the reconstruction, we present a method to retrieve a spatially varying regularization map outlining the feasible inclusion position. This approach can be made very simple by including a few multispectral recordings from only one source position. The results retrieved through tissue phantom experiments imply that initial reconstructions with spatially varying priors reduces artifacts and show slightly more accurate reconstruction results compared to reconstructions using no priors.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Optics Express
volume
15
issue
21
pages
13574 - 13584
publisher
OSA
external identifiers
  • wos:000251223100010
  • scopus:35348964199
ISSN
1094-4087
language
English
LU publication?
yes
id
7310be3d-0817-4b55-b7e8-c7190612dd70 (old id 968806)
alternative location
http://www.opticsinfobase.org/abstract.cfm?URI=oe-15-21-13574
date added to LUP
2008-01-29 12:48:50
date last changed
2017-10-22 04:50:33
@article{7310be3d-0817-4b55-b7e8-c7190612dd70,
  abstract     = {Fluorescence molecular tomography suffers from being mathematically ill-conditioned resulting in non-unique solutions to the reconstruction problem. In an attempt to reduce the number of possible solutions in the underdetermined system of equations in the reconstruction, we present a method to retrieve a spatially varying regularization map outlining the feasible inclusion position. This approach can be made very simple by including a few multispectral recordings from only one source position. The results retrieved through tissue phantom experiments imply that initial reconstructions with spatially varying priors reduces artifacts and show slightly more accurate reconstruction results compared to reconstructions using no priors.},
  author       = {Axelsson, Johan and Svensson, Jenny and Andersson-Engels, Stefan},
  issn         = {1094-4087},
  language     = {eng},
  number       = {21},
  pages        = {13574--13584},
  publisher    = {OSA},
  series       = {Optics Express},
  title        = {Spatially varying regularization based on spectrally resolved fluorescence emission in fluorescence molecular tomography},
  volume       = {15},
  year         = {2007},
}