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Delays in maturation among adolescents with hemophilia and a history of inhibitors

Donfield, Sharyne M.; Lynn, Henry S.; Lail, Alice E.; Hoots, W. Keith; Berntorp, Erik LU and Gomperts, Edward D. (2007) In Blood 110(10). p.3656-3661
Abstract
Inhibitory antibodies to factors VIII or IX have the potential to affect a broad range of outcomes among people with hemophilia; however, their possible effect on growth and maturation has not been explored. We evaluated skeletal maturation (bone age), pubertal progression, serum testosterone levels, height velocity, and stature in the multicenter Hemophilia Growth and Development Study. A total of 333 children and adolescents (mean age, 12.4 years) were enrolled from 1989 to 1990 and followed for 7 years. Of these, 18% (n = 60) had a history of inhibitors. Bone age among HIV- adolescents with a history of inhibitors lagged 9 or more months behind those without inhibitors at every age from 12 to 15 years. Those with a history of inhibitors... (More)
Inhibitory antibodies to factors VIII or IX have the potential to affect a broad range of outcomes among people with hemophilia; however, their possible effect on growth and maturation has not been explored. We evaluated skeletal maturation (bone age), pubertal progression, serum testosterone levels, height velocity, and stature in the multicenter Hemophilia Growth and Development Study. A total of 333 children and adolescents (mean age, 12.4 years) were enrolled from 1989 to 1990 and followed for 7 years. Of these, 18% (n = 60) had a history of inhibitors. Bone age among HIV- adolescents with a history of inhibitors lagged 9 or more months behind those without inhibitors at every age from 12 to 15 years. Those with a history of inhibitors were older at every Tanner stage transition, attained a lower maximum growth velocity, and their serum testosterone levels were significantly lower compared with those without inhibitors. Delays were greater among HIV+ patients with a history of inhibitors compared with those without inhibitors; however, the differences were generally small and not statistically significant. The results of this investigation underscore the importance of monitoring the growth and maturation of children and adolescents with hemophilia, particularly those with inhibitors. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
110
issue
10
pages
3656 - 3661
publisher
American Society of Hematology
external identifiers
  • wos:000250946300032
  • scopus:36348975208
ISSN
1528-0020
DOI
10.1182/blood-2007-05-088062
language
English
LU publication?
yes
id
bb0869b2-b226-4d96-8a56-6656befebb3a (old id 969303)
date added to LUP
2008-01-29 13:03:30
date last changed
2017-01-01 05:07:17
@article{bb0869b2-b226-4d96-8a56-6656befebb3a,
  abstract     = {Inhibitory antibodies to factors VIII or IX have the potential to affect a broad range of outcomes among people with hemophilia; however, their possible effect on growth and maturation has not been explored. We evaluated skeletal maturation (bone age), pubertal progression, serum testosterone levels, height velocity, and stature in the multicenter Hemophilia Growth and Development Study. A total of 333 children and adolescents (mean age, 12.4 years) were enrolled from 1989 to 1990 and followed for 7 years. Of these, 18% (n = 60) had a history of inhibitors. Bone age among HIV- adolescents with a history of inhibitors lagged 9 or more months behind those without inhibitors at every age from 12 to 15 years. Those with a history of inhibitors were older at every Tanner stage transition, attained a lower maximum growth velocity, and their serum testosterone levels were significantly lower compared with those without inhibitors. Delays were greater among HIV+ patients with a history of inhibitors compared with those without inhibitors; however, the differences were generally small and not statistically significant. The results of this investigation underscore the importance of monitoring the growth and maturation of children and adolescents with hemophilia, particularly those with inhibitors.},
  author       = {Donfield, Sharyne M. and Lynn, Henry S. and Lail, Alice E. and Hoots, W. Keith and Berntorp, Erik and Gomperts, Edward D.},
  issn         = {1528-0020},
  language     = {eng},
  number       = {10},
  pages        = {3656--3661},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Delays in maturation among adolescents with hemophilia and a history of inhibitors},
  url          = {http://dx.doi.org/10.1182/blood-2007-05-088062},
  volume       = {110},
  year         = {2007},
}