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Diagnostic accuracy for CZT gamma camera compared to conventional gamma camera technique with myocardial perfusion single-photon emission computed tomography : Assessment of myocardial infarction and function

Hedeer, Fredrik LU ; Akil, Shahnaz LU ; Oddstig, Jenny LU ; Hindorf, Cecilia LU ; Arheden, Håkan LU ; Carlsson, Marcus LU and Engblom, Henrik LU (2023) In Journal of Nuclear Cardiology 30(5). p.1935-1946
Abstract

Background: The solid-state cadmium-zinc-telluride (CZT) gamma camera for myocardial perfusion single-photon emission computed tomography (MPS) has theoretical advantages compared to the conventional gamma camera technique. This includes more sensitive detectors and better energy resolution. We aimed to explore the diagnostic performance of gated MPS with a CZT gamma camera compared to a conventional gamma camera for detection of myocardial infarct (MI) and assessment of left ventricular (LV) volumes and ejection fraction (LVEF), using cardiac magnetic resonance (CMR) as the reference method. Methods: Seventy-three patients (26% female) with known or suspected chronic coronary syndrome were examined with gated MPS using both a CZT gamma... (More)

Background: The solid-state cadmium-zinc-telluride (CZT) gamma camera for myocardial perfusion single-photon emission computed tomography (MPS) has theoretical advantages compared to the conventional gamma camera technique. This includes more sensitive detectors and better energy resolution. We aimed to explore the diagnostic performance of gated MPS with a CZT gamma camera compared to a conventional gamma camera for detection of myocardial infarct (MI) and assessment of left ventricular (LV) volumes and ejection fraction (LVEF), using cardiac magnetic resonance (CMR) as the reference method. Methods: Seventy-three patients (26% female) with known or suspected chronic coronary syndrome were examined with gated MPS using both a CZT gamma camera and a conventional gamma camera as well as with CMR. Presence and extent of MI on MPS and late gadolinium enhancement (LGE) CMR was evaluated. For LV volumes, LVEF and LV mass, gated MPS images and cine CMR images were evaluated. Results: MI was found in 42 patients on CMR. The overall sensitivity, specificity, positive and negative predictive values for the CZT and the conventional gamma camera were the same (67%, 100%, 100% and 69%). For infarct size > 3% on CMR, the sensitivity was 82% for the CZT and 73% for the conventional gamma camera, respectively. LV volumes were significantly underestimated by MPS compared to CMR (P ≤.002 for all measures). The underestimation was slightly less pronounced for the CZT compared to the conventional gamma camera (2-10 mL, P ≤.03 for all measures). For LVEF, however, accuracy was high for both gamma cameras. Conclusion: Differences between a CZT and a conventional gamma camera for detection of MI and assessment of LV volumes and LVEF are small and do not appear to be clinically significant.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CAD, Gated SPECT, MPI, MRI, Myocardial ischemia and infarction, SPECT
in
Journal of Nuclear Cardiology
volume
30
issue
5
pages
12 pages
publisher
Springer
external identifiers
  • pmid:36913172
  • scopus:85146720119
ISSN
1071-3581
DOI
10.1007/s12350-022-03185-0
language
English
LU publication?
yes
id
96cc9891-d20a-4998-9b9d-a482f0c4456d
date added to LUP
2024-01-12 12:36:38
date last changed
2024-04-13 06:04:22
@article{96cc9891-d20a-4998-9b9d-a482f0c4456d,
  abstract     = {{<p>Background: The solid-state cadmium-zinc-telluride (CZT) gamma camera for myocardial perfusion single-photon emission computed tomography (MPS) has theoretical advantages compared to the conventional gamma camera technique. This includes more sensitive detectors and better energy resolution. We aimed to explore the diagnostic performance of gated MPS with a CZT gamma camera compared to a conventional gamma camera for detection of myocardial infarct (MI) and assessment of left ventricular (LV) volumes and ejection fraction (LVEF), using cardiac magnetic resonance (CMR) as the reference method. Methods: Seventy-three patients (26% female) with known or suspected chronic coronary syndrome were examined with gated MPS using both a CZT gamma camera and a conventional gamma camera as well as with CMR. Presence and extent of MI on MPS and late gadolinium enhancement (LGE) CMR was evaluated. For LV volumes, LVEF and LV mass, gated MPS images and cine CMR images were evaluated. Results: MI was found in 42 patients on CMR. The overall sensitivity, specificity, positive and negative predictive values for the CZT and the conventional gamma camera were the same (67%, 100%, 100% and 69%). For infarct size &gt; 3% on CMR, the sensitivity was 82% for the CZT and 73% for the conventional gamma camera, respectively. LV volumes were significantly underestimated by MPS compared to CMR (P ≤.002 for all measures). The underestimation was slightly less pronounced for the CZT compared to the conventional gamma camera (2-10 mL, P ≤.03 for all measures). For LVEF, however, accuracy was high for both gamma cameras. Conclusion: Differences between a CZT and a conventional gamma camera for detection of MI and assessment of LV volumes and LVEF are small and do not appear to be clinically significant.</p>}},
  author       = {{Hedeer, Fredrik and Akil, Shahnaz and Oddstig, Jenny and Hindorf, Cecilia and Arheden, Håkan and Carlsson, Marcus and Engblom, Henrik}},
  issn         = {{1071-3581}},
  keywords     = {{CAD; Gated SPECT; MPI; MRI; Myocardial ischemia and infarction; SPECT}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1935--1946}},
  publisher    = {{Springer}},
  series       = {{Journal of Nuclear Cardiology}},
  title        = {{Diagnostic accuracy for CZT gamma camera compared to conventional gamma camera technique with myocardial perfusion single-photon emission computed tomography : Assessment of myocardial infarction and function}},
  url          = {{http://dx.doi.org/10.1007/s12350-022-03185-0}},
  doi          = {{10.1007/s12350-022-03185-0}},
  volume       = {{30}},
  year         = {{2023}},
}