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Celiac disease can be predicted by high levels of tissue transglutaminase antibodies in children and adolescents with type 1 diabetes

Cerqueiro Bybrant, Mara ; Udén, Elin ; Frederiksen, Filippa ; Gustafsson, Anna L. ; Arvidsson, Carl Göran ; Fureman, Anna Lena ; Forsander, Gun ; Elding Larsson, Helena LU ; Ivarsson, Sten A. LU and Lindgren, Marie LU , et al. (2021) In Pediatric Diabetes 22(3). p.417-424
Abstract

Objectives: Children with type 1 diabetes (T1D) are not included in guidelines regarding diagnosis criteria for celiac disease (CD) without a diagnostic biopsy, due to lack of data. We explored whether tissue transglutaminase antibodies (anti-tTG) that were ≥ 10 times the upper limit of normal (10× ULN) predicted CD in T1D. Methods: Data from the Swedish prospective Better Diabetes Diagnosis study was used, and 2035 children and adolescents with T1D diagnosed between 2005–2010 were included. Of these, 32 had been diagnosed with CD before T1D. The children without CD were repeatedly screened for CD using anti-tTG antibodies of immunoglobulin type A. In addition, their human leukocyte antigen (HLA) were genotyped. All children with... (More)

Objectives: Children with type 1 diabetes (T1D) are not included in guidelines regarding diagnosis criteria for celiac disease (CD) without a diagnostic biopsy, due to lack of data. We explored whether tissue transglutaminase antibodies (anti-tTG) that were ≥ 10 times the upper limit of normal (10× ULN) predicted CD in T1D. Methods: Data from the Swedish prospective Better Diabetes Diagnosis study was used, and 2035 children and adolescents with T1D diagnosed between 2005–2010 were included. Of these, 32 had been diagnosed with CD before T1D. The children without CD were repeatedly screened for CD using anti-tTG antibodies of immunoglobulin type A. In addition, their human leukocyte antigen (HLA) were genotyped. All children with positive anti-tTG were advised to undergo biopsy. Biopsies were performed on 119 children and graded using the Marsh-Oberhüber classification. Results: All of the 60 children with anti-tTG ≥10x ULN had CD verified by biopsies. The degree of mucosal damage correlated with anti-tTG levels. Among 2003 screened children, 6.9% had positive anti-tTG and 5.6% were confirmed CD. The overall CD prevalence, when including the 32 children with CD before T1D, was 7.0% (145/2035). All but one of the children diagnosed with CD had HLA-DQ2 and/or DQ8. Conclusions: As all screened children and adolescents with T1D with tissue transglutaminase antibodies above 10 times the positive value 10x ULN had CD, we propose that the guidelines for diagnosing CD in screened children, when biopsies can be omitted, should also apply to children and adolescents with T1D as a noninvasive method.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
biopsy, celiac disease, screening, tissue transglutaminase antibodies, type 1 diabetes
in
Pediatric Diabetes
volume
22
issue
3
pages
417 - 424
publisher
Wiley-Blackwell
external identifiers
  • scopus:85097400725
  • pmid:33259121
ISSN
1399-543X
DOI
10.1111/pedi.13165
project
Better Diabetes Diagnosis (BDD)
language
English
LU publication?
yes
id
985b0854-9285-4cdf-8ae7-f162870f8db3
date added to LUP
2020-12-23 07:54:25
date last changed
2024-06-27 04:33:47
@article{985b0854-9285-4cdf-8ae7-f162870f8db3,
  abstract     = {{<p>Objectives: Children with type 1 diabetes (T1D) are not included in guidelines regarding diagnosis criteria for celiac disease (CD) without a diagnostic biopsy, due to lack of data. We explored whether tissue transglutaminase antibodies (anti-tTG) that were ≥ 10 times the upper limit of normal (10× ULN) predicted CD in T1D. Methods: Data from the Swedish prospective Better Diabetes Diagnosis study was used, and 2035 children and adolescents with T1D diagnosed between 2005–2010 were included. Of these, 32 had been diagnosed with CD before T1D. The children without CD were repeatedly screened for CD using anti-tTG antibodies of immunoglobulin type A. In addition, their human leukocyte antigen (HLA) were genotyped. All children with positive anti-tTG were advised to undergo biopsy. Biopsies were performed on 119 children and graded using the Marsh-Oberhüber classification. Results: All of the 60 children with anti-tTG ≥10x ULN had CD verified by biopsies. The degree of mucosal damage correlated with anti-tTG levels. Among 2003 screened children, 6.9% had positive anti-tTG and 5.6% were confirmed CD. The overall CD prevalence, when including the 32 children with CD before T1D, was 7.0% (145/2035). All but one of the children diagnosed with CD had HLA-DQ2 and/or DQ8. Conclusions: As all screened children and adolescents with T1D with tissue transglutaminase antibodies above 10 times the positive value 10x ULN had CD, we propose that the guidelines for diagnosing CD in screened children, when biopsies can be omitted, should also apply to children and adolescents with T1D as a noninvasive method.</p>}},
  author       = {{Cerqueiro Bybrant, Mara and Udén, Elin and Frederiksen, Filippa and Gustafsson, Anna L. and Arvidsson, Carl Göran and Fureman, Anna Lena and Forsander, Gun and Elding Larsson, Helena and Ivarsson, Sten A. and Lindgren, Marie and Ludvigsson, Johnny and Marcus, Claude and Pundziute Lyckå, Auste and Persson, Martina and Samuelsson, Ulf and Särnblad, Stefan and Åkesson, Karin and Örtqvist, Eva and Carlsson, Annelie}},
  issn         = {{1399-543X}},
  keywords     = {{biopsy; celiac disease; screening; tissue transglutaminase antibodies; type 1 diabetes}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{417--424}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Pediatric Diabetes}},
  title        = {{Celiac disease can be predicted by high levels of tissue transglutaminase antibodies in children and adolescents with type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1111/pedi.13165}},
  doi          = {{10.1111/pedi.13165}},
  volume       = {{22}},
  year         = {{2021}},
}