Do nanoparticles provide a new opportunity for diagnosis of distal airspace disease?
(2017) In International Journal of Nanomedicine 12. p.41-51- Abstract
There is a need for efficient techniques to assess abnormalities in the peripheral regions of the lungs, for example, for diagnosis of pulmonary emphysema. Considerable scientific efforts have been directed toward measuring lung morphology by studying recovery of inhaled micron-sized aerosol particles (0.4-1.5 μm). In contrast, it is suggested that the recovery of inhaled airborne nanoparticles may be more useful for diagnosis. The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature. Using nanoparticles for studying distal airspace dimensions is shown to have several advantages over other... (More)
There is a need for efficient techniques to assess abnormalities in the peripheral regions of the lungs, for example, for diagnosis of pulmonary emphysema. Considerable scientific efforts have been directed toward measuring lung morphology by studying recovery of inhaled micron-sized aerosol particles (0.4-1.5 μm). In contrast, it is suggested that the recovery of inhaled airborne nanoparticles may be more useful for diagnosis. The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature. Using nanoparticles for studying distal airspace dimensions is shown to have several advantages over other aerosol-based methods. 1) Nanoparticles deposit almost exclusively by diffusion, which allows a simpler breathing maneuver with minor artifacts from particle losses in the oropharyngeal and upper airways. 2) A higher breathing flow rate can be utilized, making it possible to rapidly inhale from residual volume to total lung capacity (TLC), thereby eliminating the need to determine the TLC before measurement. 3) Recent studies indicate better penetration of nanoparticles than micron-sized particles into poorly ventilated and diseased regions of the lungs; thus, a stronger signal from the abnormal parts is expected. 4) Changes in airspace dimensions have a larger impact on the recovery of nanoparticles. Compared to current diagnostic techniques with high specificity for morphometric changes of the lungs, computed tomography and magnetic resonance imaging with hyperpolarized gases, an aerosol-based method is likely to be less time consuming, considerably cheaper, simpler to use, and easier to interpret (providing a single value rather than an image that has to be analyzed). Compared to diagnosis by carbon monoxide (DL,CO), the uptake of nanoparticles in the lung is not affected by blood flow, hemoglobin concentration or alterations of the alveolar membranes, but relies only on lung morphology.
(Less)
- author
- Löndahl, Jakob LU ; Jakobsson, Jonas K F LU ; Broday, David M. ; Aaltonen, H Laura LU and Wollmer, Per LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- AiDA, COPD, Emphysema, Lung particle interaction, Nanoaerosols, Respiratory diagnosis
- in
- International Journal of Nanomedicine
- volume
- 12
- pages
- 11 pages
- publisher
- Dove Medical Press Ltd.
- external identifiers
-
- scopus:85007599977
- pmid:28053522
- wos:000390463800004
- ISSN
- 1176-9114
- DOI
- 10.2147/IJN.S121369
- language
- English
- LU publication?
- yes
- id
- 98a1365f-b385-4d68-8e8c-637cd899c9b4
- date added to LUP
- 2017-03-16 11:14:37
- date last changed
- 2024-09-15 22:06:27
@article{98a1365f-b385-4d68-8e8c-637cd899c9b4, abstract = {{<p>There is a need for efficient techniques to assess abnormalities in the peripheral regions of the lungs, for example, for diagnosis of pulmonary emphysema. Considerable scientific efforts have been directed toward measuring lung morphology by studying recovery of inhaled micron-sized aerosol particles (0.4-1.5 μm). In contrast, it is suggested that the recovery of inhaled airborne nanoparticles may be more useful for diagnosis. The objective of this work is to provide a theoretical background for the use of nanoparticles in measuring lung morphology and to assess their applicability based on a review of the literature. Using nanoparticles for studying distal airspace dimensions is shown to have several advantages over other aerosol-based methods. 1) Nanoparticles deposit almost exclusively by diffusion, which allows a simpler breathing maneuver with minor artifacts from particle losses in the oropharyngeal and upper airways. 2) A higher breathing flow rate can be utilized, making it possible to rapidly inhale from residual volume to total lung capacity (TLC), thereby eliminating the need to determine the TLC before measurement. 3) Recent studies indicate better penetration of nanoparticles than micron-sized particles into poorly ventilated and diseased regions of the lungs; thus, a stronger signal from the abnormal parts is expected. 4) Changes in airspace dimensions have a larger impact on the recovery of nanoparticles. Compared to current diagnostic techniques with high specificity for morphometric changes of the lungs, computed tomography and magnetic resonance imaging with hyperpolarized gases, an aerosol-based method is likely to be less time consuming, considerably cheaper, simpler to use, and easier to interpret (providing a single value rather than an image that has to be analyzed). Compared to diagnosis by carbon monoxide (D<sub>L,CO</sub>), the uptake of nanoparticles in the lung is not affected by blood flow, hemoglobin concentration or alterations of the alveolar membranes, but relies only on lung morphology.</p>}}, author = {{Löndahl, Jakob and Jakobsson, Jonas K F and Broday, David M. and Aaltonen, H Laura and Wollmer, Per}}, issn = {{1176-9114}}, keywords = {{AiDA; COPD; Emphysema; Lung particle interaction; Nanoaerosols; Respiratory diagnosis}}, language = {{eng}}, pages = {{41--51}}, publisher = {{Dove Medical Press Ltd.}}, series = {{International Journal of Nanomedicine}}, title = {{Do nanoparticles provide a new opportunity for diagnosis of distal airspace disease?}}, url = {{http://dx.doi.org/10.2147/IJN.S121369}}, doi = {{10.2147/IJN.S121369}}, volume = {{12}}, year = {{2017}}, }