Glucose homeostasis, beta cell function, and insulin resistance in relation to vitamin D status after gestational diabetes mellitus
(2017) In Acta Obstetricia et Gynecologica Scandinavica 96(7). p.821-827- Abstract
Introduction: We wanted to determine vitamin D status after gestational diabetes mellitus (GDM) and to evaluate whether levels of 25-hydroxyvitamin D3 (25OHD3) are associated with beta cell function, insulin resistance or a diagnosis of diabetes after GDM. Material and methods: Glucose homeostasis was assessed during a 75-g oral glucose tolerance test one to two years after delivery in 376 women with previous GDM (287 European and 78 non-European, including 33 Arab and 35 Asian women). Insulin resistance was estimated using homeostasis model assessment of insulin resistance (HOMA-IR). The insulinogenic index (I/G30) and the disposition index [(I/G30)/HOMA-IR] were used to calculate insulin secretion. Concentrations... (More)
Introduction: We wanted to determine vitamin D status after gestational diabetes mellitus (GDM) and to evaluate whether levels of 25-hydroxyvitamin D3 (25OHD3) are associated with beta cell function, insulin resistance or a diagnosis of diabetes after GDM. Material and methods: Glucose homeostasis was assessed during a 75-g oral glucose tolerance test one to two years after delivery in 376 women with previous GDM (287 European and 78 non-European, including 33 Arab and 35 Asian women). Insulin resistance was estimated using homeostasis model assessment of insulin resistance (HOMA-IR). The insulinogenic index (I/G30) and the disposition index [(I/G30)/HOMA-IR] were used to calculate insulin secretion. Concentrations of serum 25OHD3 were determined. Results: Mean (±SD) 25OHD3 concentration was 50.0 ± 22.3 nmol/L and differed significantly among subgroups of body mass index, ethnicity, and glucose tolerance status; 53% had 25OHD3 levels <50 nmol/L and 87% had 25OHD3 levels <75 nmol/L. There was a negative correlation between 25OHD3 concentration and HOMA-IR (p < 0.001) and a positive correlation between 25OHD3 and disposition index (p = 0.002) in univariable regression analysis. Correlations attenuated after adjustment for body mass index. In univariable regression analysis, 25OHD3 concentrations were significantly associated with diabetes after GDM (p = 0.004). However, in a multivariable model, non-European origin, HOMA-IR and insulinogenic index were significantly associated with postpartum diabetes, whereas 25OHD3 concentrations were not. Conclusion: Vitamin D deficiency/insufficiency in previous GDM cases appears to be associated with beta cell dysfunction and insulin resistance, but not with postpartum diabetes when factors well known to influence type-2 diabetes were adjusted for.
(Less)
- author
- Shaat, Nael
LU
; Ignell, Claes LU
; Katsarou, Anastasia LU and Berntorp, Kerstin LU
- organization
- publishing date
- 2017
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Disposition index, Ethnicity, Gestational diabetes, HOMA-IR, Insulinogenic index, OGTT, Postpartum diabetes, Vitamin D
- in
- Acta Obstetricia et Gynecologica Scandinavica
- volume
- 96
- issue
- 7
- pages
- 821 - 827
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:28276579
- wos:000403899400005
- scopus:85017527797
- ISSN
- 0001-6349
- DOI
- 10.1111/aogs.13124
- language
- English
- LU publication?
- yes
- id
- 99695ce1-bf64-4c71-a515-5fc395b8a370
- date added to LUP
- 2017-05-04 17:00:38
- date last changed
- 2025-01-07 12:33:34
@article{99695ce1-bf64-4c71-a515-5fc395b8a370, abstract = {{<p>Introduction: We wanted to determine vitamin D status after gestational diabetes mellitus (GDM) and to evaluate whether levels of 25-hydroxyvitamin D<sub>3</sub> (25OHD<sub>3</sub>) are associated with beta cell function, insulin resistance or a diagnosis of diabetes after GDM. Material and methods: Glucose homeostasis was assessed during a 75-g oral glucose tolerance test one to two years after delivery in 376 women with previous GDM (287 European and 78 non-European, including 33 Arab and 35 Asian women). Insulin resistance was estimated using homeostasis model assessment of insulin resistance (HOMA-IR). The insulinogenic index (I/G30) and the disposition index [(I/G30)/HOMA-IR] were used to calculate insulin secretion. Concentrations of serum 25OHD<sub>3</sub> were determined. Results: Mean (±SD) 25OHD<sub>3</sub> concentration was 50.0 ± 22.3 nmol/L and differed significantly among subgroups of body mass index, ethnicity, and glucose tolerance status; 53% had 25OHD<sub>3</sub> levels <50 nmol/L and 87% had 25OHD<sub>3</sub> levels <75 nmol/L. There was a negative correlation between 25OHD<sub>3</sub> concentration and HOMA-IR (p < 0.001) and a positive correlation between 25OHD<sub>3</sub> and disposition index (p = 0.002) in univariable regression analysis. Correlations attenuated after adjustment for body mass index. In univariable regression analysis, 25OHD<sub>3</sub> concentrations were significantly associated with diabetes after GDM (p = 0.004). However, in a multivariable model, non-European origin, HOMA-IR and insulinogenic index were significantly associated with postpartum diabetes, whereas 25OHD<sub>3</sub> concentrations were not. Conclusion: Vitamin D deficiency/insufficiency in previous GDM cases appears to be associated with beta cell dysfunction and insulin resistance, but not with postpartum diabetes when factors well known to influence type-2 diabetes were adjusted for.</p>}}, author = {{Shaat, Nael and Ignell, Claes and Katsarou, Anastasia and Berntorp, Kerstin}}, issn = {{0001-6349}}, keywords = {{Disposition index; Ethnicity; Gestational diabetes; HOMA-IR; Insulinogenic index; OGTT; Postpartum diabetes; Vitamin D}}, language = {{eng}}, number = {{7}}, pages = {{821--827}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Obstetricia et Gynecologica Scandinavica}}, title = {{Glucose homeostasis, beta cell function, and insulin resistance in relation to vitamin D status after gestational diabetes mellitus}}, url = {{https://lup.lub.lu.se/search/files/35022811/24906521.pdf}}, doi = {{10.1111/aogs.13124}}, volume = {{96}}, year = {{2017}}, }