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Learning Stimulus Intervals – Adaptive Timing of Conditioned Purkinje Cell Responses

Jirenhed, Dan-Anders LU and Hesslow, Germund LU (2011) In Cerebellum 10(Online March 17, 2011). p.523-535
Abstract
Classical conditioning of motor responses, such as the eyeblink response, is an experimental model of associative learning and of adaptive timing of movements. A conditioned blink will have its maximum amplitude near the expected onset of the unconditioned blink-eliciting stimulus and it adapts to changes in the interval between the conditioned and unconditioned stimuli. Previous studies have shown that an eyeblink conditioning protocol can make cerebellar Purkinje cells learn to pause in response to the conditioned stimulus. According to the cerebellar cortical conditioning model, this conditioned Purkinje cell response drives the overt blink. If so, the model predicts that the temporal properties of the Purkinje cell response reflect the... (More)
Classical conditioning of motor responses, such as the eyeblink response, is an experimental model of associative learning and of adaptive timing of movements. A conditioned blink will have its maximum amplitude near the expected onset of the unconditioned blink-eliciting stimulus and it adapts to changes in the interval between the conditioned and unconditioned stimuli. Previous studies have shown that an eyeblink conditioning protocol can make cerebellar Purkinje cells learn to pause in response to the conditioned stimulus. According to the cerebellar cortical conditioning model, this conditioned Purkinje cell response drives the overt blink. If so, the model predicts that the temporal properties of the Purkinje cell response reflect the overt behaviour. To test this prediction, in vivo recordings of Purkinje cell activity were performed in decerebrate ferrets during conditioning, using direct stimulation of cerebellar mossy and climbing fibre afferents as conditioned and unconditioned stimuli. The results show that Purkinje cells not only develop a change in responsiveness to the conditioned stimulus. They also learn a particular temporal response profile where the timing, not only of onset and maximum but also of offset, is determined by the temporal interval between the conditioned and unconditioned stimuli. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cerebellum
volume
10
issue
Online March 17, 2011
pages
523 - 535
publisher
Informa Healthcare
external identifiers
  • pmid:21416378
  • scopus:80455129226
ISSN
1473-4230
DOI
10.1007/s12311-011-0264-3
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
9c34fb92-d4a3-4de4-836a-d3abaabd789f (old id 1788029)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/21416378?dopt=Abstract
date added to LUP
2011-03-04 11:39:57
date last changed
2017-06-25 03:11:35
@article{9c34fb92-d4a3-4de4-836a-d3abaabd789f,
  abstract     = {Classical conditioning of motor responses, such as the eyeblink response, is an experimental model of associative learning and of adaptive timing of movements. A conditioned blink will have its maximum amplitude near the expected onset of the unconditioned blink-eliciting stimulus and it adapts to changes in the interval between the conditioned and unconditioned stimuli. Previous studies have shown that an eyeblink conditioning protocol can make cerebellar Purkinje cells learn to pause in response to the conditioned stimulus. According to the cerebellar cortical conditioning model, this conditioned Purkinje cell response drives the overt blink. If so, the model predicts that the temporal properties of the Purkinje cell response reflect the overt behaviour. To test this prediction, in vivo recordings of Purkinje cell activity were performed in decerebrate ferrets during conditioning, using direct stimulation of cerebellar mossy and climbing fibre afferents as conditioned and unconditioned stimuli. The results show that Purkinje cells not only develop a change in responsiveness to the conditioned stimulus. They also learn a particular temporal response profile where the timing, not only of onset and maximum but also of offset, is determined by the temporal interval between the conditioned and unconditioned stimuli.},
  author       = {Jirenhed, Dan-Anders and Hesslow, Germund},
  issn         = {1473-4230},
  language     = {eng},
  number       = {Online March 17, 2011},
  pages        = {523--535},
  publisher    = {Informa Healthcare},
  series       = {Cerebellum},
  title        = {Learning Stimulus Intervals – Adaptive Timing of Conditioned Purkinje Cell Responses},
  url          = {http://dx.doi.org/10.1007/s12311-011-0264-3},
  volume       = {10},
  year         = {2011},
}