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Psychosocial health and levels of employment in 851 hypopituitary Swedish patients on long-term GH therapy.

Holmer, Helene LU ; Svensson, Johan LU ; Rylander, Lars LU ; Johannsson, Gudmundur; Rosén, Thord; Bengtsson, Bengt A LU ; Thorén, Marja; Höybye, Charlotte; Degerblad, Marie and Bramnert, Margareta LU , et al. (2013) In Psychoneuroendocrinology 38(6). p.842-852
Abstract
CONTEXT: The psychosocial health and working capacity in hypopituitary patients receiving long-term growth hormone (GH) therapy are unknown. OBJECTIVE: Psychosocial health and levels of employment were compared between GH deficient (GHD) patients on long-term replacement and the general population. DESIGN AND PARTICIPANTS: In a Swedish nationwide study, 851 GHD patients [101 childhood onset (CO) and 750 adult onset (AO)] and 2622 population controls answered a questionnaire regarding current living, employment and educational level, alcohol consumption and smoking habits. The median time on GH therapy for both men and women with CO GHD was 9 years and for AO GHD 6 years, respectively. RESULTS: As compared to the controls, the GHD patients... (More)
CONTEXT: The psychosocial health and working capacity in hypopituitary patients receiving long-term growth hormone (GH) therapy are unknown. OBJECTIVE: Psychosocial health and levels of employment were compared between GH deficient (GHD) patients on long-term replacement and the general population. DESIGN AND PARTICIPANTS: In a Swedish nationwide study, 851 GHD patients [101 childhood onset (CO) and 750 adult onset (AO)] and 2622 population controls answered a questionnaire regarding current living, employment and educational level, alcohol consumption and smoking habits. The median time on GH therapy for both men and women with CO GHD was 9 years and for AO GHD 6 years, respectively. RESULTS: As compared to the controls, the GHD patients were less often working full time, more often on sick leave/disability pension, and to a larger extent alcohol abstainers and never smokers (all; P<0.05). Predominantly CO GHD women and men, but to some extent also AO GHD women and men, lived less frequently with a partner and more often with their parents. Particularly AO GHD craniopharyngioma women used more antidepressants, while AO GHD men with a craniopharyngioma used more analgesics. CONCLUSIONS: A working capacity to the level of the general population was not achieved among hypopituitary patients, although receiving long-term GH therapy. Patients were less likely to use alcohol and tobacco. The CO GHD population lived a less independent life. (Less)
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Psychoneuroendocrinology
volume
38
issue
6
pages
842 - 852
publisher
Elsevier
external identifiers
  • wos:000319540000011
  • pmid:23040973
  • scopus:84877065154
ISSN
1873-3360
DOI
10.1016/j.psyneuen.2012.09.008
language
English
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yes
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9c481572-4325-4b30-ba46-a78b83fa1d88 (old id 3161027)
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http://www.ncbi.nlm.nih.gov/pubmed/23040973?dopt=Abstract
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2012-11-01 13:34:29
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2019-06-11 01:18:48
@article{9c481572-4325-4b30-ba46-a78b83fa1d88,
  abstract     = {CONTEXT: The psychosocial health and working capacity in hypopituitary patients receiving long-term growth hormone (GH) therapy are unknown. OBJECTIVE: Psychosocial health and levels of employment were compared between GH deficient (GHD) patients on long-term replacement and the general population. DESIGN AND PARTICIPANTS: In a Swedish nationwide study, 851 GHD patients [101 childhood onset (CO) and 750 adult onset (AO)] and 2622 population controls answered a questionnaire regarding current living, employment and educational level, alcohol consumption and smoking habits. The median time on GH therapy for both men and women with CO GHD was 9 years and for AO GHD 6 years, respectively. RESULTS: As compared to the controls, the GHD patients were less often working full time, more often on sick leave/disability pension, and to a larger extent alcohol abstainers and never smokers (all; P&lt;0.05). Predominantly CO GHD women and men, but to some extent also AO GHD women and men, lived less frequently with a partner and more often with their parents. Particularly AO GHD craniopharyngioma women used more antidepressants, while AO GHD men with a craniopharyngioma used more analgesics. CONCLUSIONS: A working capacity to the level of the general population was not achieved among hypopituitary patients, although receiving long-term GH therapy. Patients were less likely to use alcohol and tobacco. The CO GHD population lived a less independent life.},
  author       = {Holmer, Helene and Svensson, Johan and Rylander, Lars and Johannsson, Gudmundur and Rosén, Thord and Bengtsson, Bengt A and Thorén, Marja and Höybye, Charlotte and Degerblad, Marie and Bramnert, Margareta and Hägg, Erik and Engström, Britt Edén and Ekman, Bertil and Erfurth, Eva Marie},
  issn         = {1873-3360},
  language     = {eng},
  number       = {6},
  pages        = {842--852},
  publisher    = {Elsevier},
  series       = {Psychoneuroendocrinology},
  title        = {Psychosocial health and levels of employment in 851 hypopituitary Swedish patients on long-term GH therapy.},
  url          = {http://dx.doi.org/10.1016/j.psyneuen.2012.09.008},
  volume       = {38},
  year         = {2013},
}