Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age : an observational study
Zaigham, Mehreen LU
; Hellström-Westas, Lena
LU
; Domellöf, Magnus
and Andersson, Ola
LU
(2020)
In BMC Pregnancy and Childbirth
20(1).
p.564-564
- Abstract
BACKGROUND: With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born infants.
METHODS: We conducted a prospective, observational study of infants delivered by prelabour caesarean section at the Hospital of Halland, Halmstad, Sweden and compared their development with an historical group of infants born by non-instrumental vaginal delivery.
RESULTS: Infants born by prelabour caesarean section were compared with a group of vaginally born infants. Follow-up assessments were performed at 4 and 12... (More)
BACKGROUND: With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born infants.
METHODS: We conducted a prospective, observational study of infants delivered by prelabour caesarean section at the Hospital of Halland, Halmstad, Sweden and compared their development with an historical group of infants born by non-instrumental vaginal delivery.
RESULTS: Infants born by prelabour caesarean section were compared with a group of vaginally born infants. Follow-up assessments were performed at 4 and 12 months. Prelabour caesarean infants (n = 66) had significantly lower Ages and Stages Questionnaire, second edition (ASQ-II) scores in all domains (communication, gross motor, fine motor, problem solving and personal-social) at 4 months of age with an adjusted mean difference (95% CI) of - 20.7 (- 28.7 to - 12.6) in ASQ-II total score as compared to vaginally born infants (n = 352). These differences remained for gross-motor skills at the 12 month assessment, adjusted mean difference (95% CI) -4.7 (- 8.8 to - 0.7), n = 62 and 336.
CONCLUSIONS: Adverse neurodevelopmental outcomes in infants born by prelabour caesarean section may be apparent already a few months after birth. Additional studies are warranted to explore this relationship further.
(Less)
- author
- Zaigham, Mehreen
LU
; Hellström-Westas, Lena
LU
; Domellöf, Magnus
and Andersson, Ola
LU
- organization
- publishing date
- 2020-09-25
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Pregnancy and Childbirth
- volume
- 20
- issue
- 1
- pages
- 564 - 564
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:32977763
- scopus:85091807960
- ISSN
- 1471-2393
- DOI
- 10.1186/s12884-020-03253-8
- language
- English
- LU publication?
- yes
- id
- 9c73b996-9836-468e-9ed3-240adf255596
- date added to LUP
- 2020-09-30 00:53:15
- date last changed
- 2024-06-12 21:37:28
@article{9c73b996-9836-468e-9ed3-240adf255596,
abstract = {{<p>BACKGROUND: With prelabour caesarean section rates growing globally, there is direct and indirect evidence of negative cognitive outcomes in childhood. The objective of this study was to assess the short-term neurodevelopmental outcomes after prelabour caesarean section as compared to vaginally born infants.</p><p>METHODS: We conducted a prospective, observational study of infants delivered by prelabour caesarean section at the Hospital of Halland, Halmstad, Sweden and compared their development with an historical group of infants born by non-instrumental vaginal delivery.</p><p>RESULTS: Infants born by prelabour caesarean section were compared with a group of vaginally born infants. Follow-up assessments were performed at 4 and 12 months. Prelabour caesarean infants (n = 66) had significantly lower Ages and Stages Questionnaire, second edition (ASQ-II) scores in all domains (communication, gross motor, fine motor, problem solving and personal-social) at 4 months of age with an adjusted mean difference (95% CI) of - 20.7 (- 28.7 to - 12.6) in ASQ-II total score as compared to vaginally born infants (n = 352). These differences remained for gross-motor skills at the 12 month assessment, adjusted mean difference (95% CI) -4.7 (- 8.8 to - 0.7), n = 62 and 336.</p><p>CONCLUSIONS: Adverse neurodevelopmental outcomes in infants born by prelabour caesarean section may be apparent already a few months after birth. Additional studies are warranted to explore this relationship further.</p>}},
author = {{Zaigham, Mehreen and Hellström-Westas, Lena and Domellöf, Magnus and Andersson, Ola}},
issn = {{1471-2393}},
language = {{eng}},
month = {{09}},
number = {{1}},
pages = {{564--564}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Pregnancy and Childbirth}},
title = {{Prelabour caesarean section and neurodevelopmental outcome at 4 and 12 months of age : an observational study}},
url = {{http://dx.doi.org/10.1186/s12884-020-03253-8}},
doi = {{10.1186/s12884-020-03253-8}},
volume = {{20}},
year = {{2020}},
}