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Cancer risks in Crohn disease patients

Hemminki, K LU ; Li, X LU ; Sundquist, J LU and Sundquist, K LU (2009) In Annals of oncology : official journal of the European Society for Medical Oncology 20(3). p.80-574
Abstract

BACKGROUND: Patients diagnosed with Crohn disease (CD) are known to be at an increased risk of bowel cancers and lymphoma. CD is an autoimmune disease and we hypothesize that the patients are predisposed to a wider spectrum of cancers.

PATIENTS AND METHODS: A CD research database was constructed by identifying hospitalized CD patients from the Hospital Discharge Register and cancer patients from the Swedish Cancer Registry. Follow-up of 21 788 CD patients first hospitalized during the years 1964-2004 identified 1424 cancer cases. Standardized incidence ratios (SIRs) were calculated by comparing cancers in CD patients with subjects without CD.

RESULTS: In addition to the known sites, many additional sites were in excess in CD... (More)

BACKGROUND: Patients diagnosed with Crohn disease (CD) are known to be at an increased risk of bowel cancers and lymphoma. CD is an autoimmune disease and we hypothesize that the patients are predisposed to a wider spectrum of cancers.

PATIENTS AND METHODS: A CD research database was constructed by identifying hospitalized CD patients from the Hospital Discharge Register and cancer patients from the Swedish Cancer Registry. Follow-up of 21 788 CD patients first hospitalized during the years 1964-2004 identified 1424 cancer cases. Standardized incidence ratios (SIRs) were calculated by comparing cancers in CD patients with subjects without CD.

RESULTS: In addition to the known sites, many additional sites were in excess in CD patients. These included liver, pancreatic, lung, prostate, testicular, kidney and skin (squamous cell) cancers; nonthyroid endocrine tumors and leukemia. The previously established sites showed the highest SIRs; however, SIRs >2.0 were noted for the novel sites of the liver, testis and kidney. For testicular cancer, the SIR of seminoma was 2.74. Cancer risks were influences by age at first hospitalization for CD but whether the age effects were increasing or decreasing depending on the cancer type.

CONCLUSIONS: This large study identified many novel subsequent cancers in CD patients.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Crohn Disease/complications, Humans, Incidence, Neoplasms/complications, Registries, Risk Factors, Sweden/epidemiology
in
Annals of oncology : official journal of the European Society for Medical Oncology
volume
20
issue
3
pages
80 - 574
publisher
Oxford University Press
external identifiers
  • scopus:61649127794
  • pmid:18765463
ISSN
1569-8041
DOI
10.1093/annonc/mdn595
language
English
LU publication?
no
id
9cbfefaf-4391-4345-b846-a25bcf5920d4
date added to LUP
2019-01-30 10:55:57
date last changed
2019-11-20 05:36:25
@article{9cbfefaf-4391-4345-b846-a25bcf5920d4,
  abstract     = {<p>BACKGROUND: Patients diagnosed with Crohn disease (CD) are known to be at an increased risk of bowel cancers and lymphoma. CD is an autoimmune disease and we hypothesize that the patients are predisposed to a wider spectrum of cancers.</p><p>PATIENTS AND METHODS: A CD research database was constructed by identifying hospitalized CD patients from the Hospital Discharge Register and cancer patients from the Swedish Cancer Registry. Follow-up of 21 788 CD patients first hospitalized during the years 1964-2004 identified 1424 cancer cases. Standardized incidence ratios (SIRs) were calculated by comparing cancers in CD patients with subjects without CD.</p><p>RESULTS: In addition to the known sites, many additional sites were in excess in CD patients. These included liver, pancreatic, lung, prostate, testicular, kidney and skin (squamous cell) cancers; nonthyroid endocrine tumors and leukemia. The previously established sites showed the highest SIRs; however, SIRs &gt;2.0 were noted for the novel sites of the liver, testis and kidney. For testicular cancer, the SIR of seminoma was 2.74. Cancer risks were influences by age at first hospitalization for CD but whether the age effects were increasing or decreasing depending on the cancer type.</p><p>CONCLUSIONS: This large study identified many novel subsequent cancers in CD patients.</p>},
  author       = {Hemminki, K and Li, X and Sundquist, J and Sundquist, K},
  issn         = {1569-8041},
  language     = {eng},
  number       = {3},
  pages        = {80--574},
  publisher    = {Oxford University Press},
  series       = {Annals of oncology : official journal of the European Society for Medical Oncology},
  title        = {Cancer risks in Crohn disease patients},
  url          = {http://dx.doi.org/10.1093/annonc/mdn595},
  doi          = {10.1093/annonc/mdn595},
  volume       = {20},
  year         = {2009},
}