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Second primary cancers after cancer of unknown primary in Sweden and Germany: efficacy of the modern work-up.

Liu, Hao LU ; Hemminki, Kari LU ; Sundquist, Jan LU ; Holleczek, Bernd; Katalinic, Alexander; Emrich, Katharina and Brenner, Hermann (2013) In European Journal of Cancer Prevention 22(3). p.210-214
Abstract
In unsparing efforts to find the hidden primaries, second primary cancers (SPCs) unrelated to cancer of unknown primary (CUP) are found. The detection rates of SPCs after CUP can be considered as measures for the effectiveness of modern diagnostic techniques in finding tumors. We aimed to compare the rates of specific SPCs found after the work-up of CUP and the more sign/symptom-directed diagnostic approaches applied after any other cancer. The number of CUP patients identified in the nationwide Swedish database and nine German cancer registries was 24 641 from 1997 through 2006, and rate ratios (RRs) for SPCs were recorded in two follow-up periods. The detection rate of SPCs immediately after any other cancer was about two times higher in... (More)
In unsparing efforts to find the hidden primaries, second primary cancers (SPCs) unrelated to cancer of unknown primary (CUP) are found. The detection rates of SPCs after CUP can be considered as measures for the effectiveness of modern diagnostic techniques in finding tumors. We aimed to compare the rates of specific SPCs found after the work-up of CUP and the more sign/symptom-directed diagnostic approaches applied after any other cancer. The number of CUP patients identified in the nationwide Swedish database and nine German cancer registries was 24 641 from 1997 through 2006, and rate ratios (RRs) for SPCs were recorded in two follow-up periods. The detection rate of SPCs immediately after any other cancer was about two times higher in Germany than in Sweden, but the rate immediately after CUP was almost the same for the two datasets. In the joint analyses after CUP, the RRs of liver, lung, breast, and kidney cancers were higher than after any other cancer, whereas the RRs of prostate, urinary bladder, and connective tissue cancers as well as non-Hodgkin's lymphoma were not significantly different; the RR of cancers of upper aerodigestive tract was lower after CUP than after any other cancer. The joint data indicate that the work-up is efficient in detecting tumors in the thoracoabdominal organs that are screened by computed tomography. For some other organ sites, the more sign/symptom-directed diagnostic approaches may be equally efficient. However, none of the applied techniques could detect all tumors immediately after the first diagnosis. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Cancer Prevention
volume
22
issue
3
pages
210 - 214
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000316733600002
  • pmid:22960777
  • scopus:84875848756
ISSN
1473-5709
DOI
10.1097/CEJ.0b013e3283592c62
language
English
LU publication?
yes
id
9cdb694a-9799-46aa-8567-b6bae048f6b3 (old id 3124103)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22960777?dopt=Abstract
date added to LUP
2012-10-04 17:01:11
date last changed
2019-02-20 02:19:21
@article{9cdb694a-9799-46aa-8567-b6bae048f6b3,
  abstract     = {In unsparing efforts to find the hidden primaries, second primary cancers (SPCs) unrelated to cancer of unknown primary (CUP) are found. The detection rates of SPCs after CUP can be considered as measures for the effectiveness of modern diagnostic techniques in finding tumors. We aimed to compare the rates of specific SPCs found after the work-up of CUP and the more sign/symptom-directed diagnostic approaches applied after any other cancer. The number of CUP patients identified in the nationwide Swedish database and nine German cancer registries was 24 641 from 1997 through 2006, and rate ratios (RRs) for SPCs were recorded in two follow-up periods. The detection rate of SPCs immediately after any other cancer was about two times higher in Germany than in Sweden, but the rate immediately after CUP was almost the same for the two datasets. In the joint analyses after CUP, the RRs of liver, lung, breast, and kidney cancers were higher than after any other cancer, whereas the RRs of prostate, urinary bladder, and connective tissue cancers as well as non-Hodgkin's lymphoma were not significantly different; the RR of cancers of upper aerodigestive tract was lower after CUP than after any other cancer. The joint data indicate that the work-up is efficient in detecting tumors in the thoracoabdominal organs that are screened by computed tomography. For some other organ sites, the more sign/symptom-directed diagnostic approaches may be equally efficient. However, none of the applied techniques could detect all tumors immediately after the first diagnosis.},
  author       = {Liu, Hao and Hemminki, Kari and Sundquist, Jan and Holleczek, Bernd and Katalinic, Alexander and Emrich, Katharina and Brenner, Hermann},
  issn         = {1473-5709},
  language     = {eng},
  number       = {3},
  pages        = {210--214},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {European Journal of Cancer Prevention},
  title        = {Second primary cancers after cancer of unknown primary in Sweden and Germany: efficacy of the modern work-up.},
  url          = {http://dx.doi.org/10.1097/CEJ.0b013e3283592c62},
  volume       = {22},
  year         = {2013},
}