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Timing of Puberty, Pubertal Growth, and Adult Height in Short Children Born Small for Gestational Age Treated With Growth Hormone

Upners, Emmie N. ; Raket, Lars Lau LU orcid ; Petersen, Jørgen H. ; Thankamony, Ajay ; Roche, Edna ; Shaikh, Guftar ; Kirk, Jeremy ; Hoey, Hilary ; Ivarsson, Sten A. LU and Soder, Olle , et al. (2022) In Journal of Clinical Endocrinology and Metabolism 107(8). p.2286-2295
Abstract

Context: Growth hormone (GH) is used to treat short children born small for gestational age (SGA); however, the effects of treatment on pubertal timing and adult height are rarely studied. Objective: To evaluate adult height and peak height velocity in short GH-treated SGA children. Methods: Prospective longitudinal multicenter study. Participants were short children born SGA treated with GH therapy (n = 102). Adult height was reported in 47 children. A reference cohort of Danish children was used. Main outcome measures were adult height, peak height velocity, age at peak height, and pubertal onset. Pubertal onset was converted to SD score (SDS) using Danish reference data. Results: Gain in height SDS from start of treatment until adult... (More)

Context: Growth hormone (GH) is used to treat short children born small for gestational age (SGA); however, the effects of treatment on pubertal timing and adult height are rarely studied. Objective: To evaluate adult height and peak height velocity in short GH-treated SGA children. Methods: Prospective longitudinal multicenter study. Participants were short children born SGA treated with GH therapy (n = 102). Adult height was reported in 47 children. A reference cohort of Danish children was used. Main outcome measures were adult height, peak height velocity, age at peak height, and pubertal onset. Pubertal onset was converted to SD score (SDS) using Danish reference data. Results: Gain in height SDS from start of treatment until adult height was significant in both girls (0.94 [0.75; 1.53] SDS, P = .02) and boys (1.57 [1.13; 2.15] SDS, P < .001). No difference in adult height between GH dosage groups was observed. Peak height velocity was lower than a reference cohort for girls (6.5 [5.9; 7.6] cm/year vs 7.9 [7.4; 8.5] cm/year, P < .001) and boys (9.5 [8.4; 10.7] cm/year vs 10.1 [9.7; 10.7] cm/year, P = .002), but no difference in age at peak height velocity was seen. Puberty onset was earlier in SGA boys than a reference cohort (1.06 [-0.03; 1.96] SDS vs 0 SDS, P = .002) but not in girls (0.38 [-0.19; 1.05] SDS vs 0 SDS, P = .18). Conclusion: GH treatment improved adult height. Peak height velocity was reduced, but age at peak height velocity did not differ compared with the reference cohort. SGA boys had an earlier pubertal onset compared with the reference cohort.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adult height, GH treatment, peak height velocity, puberty, SGA
in
Journal of Clinical Endocrinology and Metabolism
volume
107
issue
8
pages
10 pages
publisher
Oxford University Press
external identifiers
  • pmid:35521800
  • scopus:85134434586
ISSN
0021-972X
DOI
10.1210/clinem/dgac282
language
English
LU publication?
yes
id
9d4e08ba-33f0-4526-8a00-817c25309059
date added to LUP
2022-09-30 15:08:44
date last changed
2025-01-07 17:00:00
@article{9d4e08ba-33f0-4526-8a00-817c25309059,
  abstract     = {{<p>Context: Growth hormone (GH) is used to treat short children born small for gestational age (SGA); however, the effects of treatment on pubertal timing and adult height are rarely studied. Objective: To evaluate adult height and peak height velocity in short GH-treated SGA children. Methods: Prospective longitudinal multicenter study. Participants were short children born SGA treated with GH therapy (n = 102). Adult height was reported in 47 children. A reference cohort of Danish children was used. Main outcome measures were adult height, peak height velocity, age at peak height, and pubertal onset. Pubertal onset was converted to SD score (SDS) using Danish reference data. Results: Gain in height SDS from start of treatment until adult height was significant in both girls (0.94 [0.75; 1.53] SDS, P = .02) and boys (1.57 [1.13; 2.15] SDS, P &lt; .001). No difference in adult height between GH dosage groups was observed. Peak height velocity was lower than a reference cohort for girls (6.5 [5.9; 7.6] cm/year vs 7.9 [7.4; 8.5] cm/year, P &lt; .001) and boys (9.5 [8.4; 10.7] cm/year vs 10.1 [9.7; 10.7] cm/year, P = .002), but no difference in age at peak height velocity was seen. Puberty onset was earlier in SGA boys than a reference cohort (1.06 [-0.03; 1.96] SDS vs 0 SDS, P = .002) but not in girls (0.38 [-0.19; 1.05] SDS vs 0 SDS, P = .18). Conclusion: GH treatment improved adult height. Peak height velocity was reduced, but age at peak height velocity did not differ compared with the reference cohort. SGA boys had an earlier pubertal onset compared with the reference cohort.</p>}},
  author       = {{Upners, Emmie N. and Raket, Lars Lau and Petersen, Jørgen H. and Thankamony, Ajay and Roche, Edna and Shaikh, Guftar and Kirk, Jeremy and Hoey, Hilary and Ivarsson, Sten A. and Soder, Olle and Juul, Anders and Jensen, Rikke Beck}},
  issn         = {{0021-972X}},
  keywords     = {{adult height; GH treatment; peak height velocity; puberty; SGA}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{2286--2295}},
  publisher    = {{Oxford University Press}},
  series       = {{Journal of Clinical Endocrinology and Metabolism}},
  title        = {{Timing of Puberty, Pubertal Growth, and Adult Height in Short Children Born Small for Gestational Age Treated With Growth Hormone}},
  url          = {{http://dx.doi.org/10.1210/clinem/dgac282}},
  doi          = {{10.1210/clinem/dgac282}},
  volume       = {{107}},
  year         = {{2022}},
}