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High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes

Svensson, Jannet ; Eising, Stefanie ; Mortensen, Henrik Bindesbol ; Christiansen, Michael ; Laursen, Inga ; Lernmark, Åke LU orcid ; Ramelius, Anita LU ; Simonsen, Lars Bjarke ; Carstensen, Bendix and Pociot, Flemming , et al. (2012) In Human Immunology 73(1). p.17-25
Abstract
The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p < 0.01) and higher IgA levels (p = 0.045), whereas no differences in IgE or IgM (p > 0.5) levels were found. Age-specific levels were unchanged over a 9-year... (More)
The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p < 0.01) and higher IgA levels (p = 0.045), whereas no differences in IgE or IgM (p > 0.5) levels were found. Age-specific levels were unchanged over a 9-year period. In patients and siblings IgG. IgA and IgE increased by age (p < 0.001); which was in contrast to IgM (p > 0.05). The continued increase in IgG levels by age indicates that adult levels are reached later than in previously studied cohorts, thereby indicating a slower maturation of the immune system. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Type 1 diabetes, Immunoglobulin, Incidence, Hygiene
in
Human Immunology
volume
73
issue
1
pages
17 - 25
publisher
Elsevier
external identifiers
  • wos:000299246900003
  • scopus:84355162820
  • pmid:22057035
ISSN
0198-8859
DOI
10.1016/j.humimm.2011.10.019
language
English
LU publication?
yes
id
9dfa5f3b-3d50-4b30-b3a2-742364ae7bcf (old id 2358423)
date added to LUP
2016-04-01 10:16:50
date last changed
2025-04-04 15:09:00
@article{9dfa5f3b-3d50-4b30-b3a2-742364ae7bcf,
  abstract     = {{The incidence of type 1 diabetes (T1D) is increasing, either because of environmental factors accelerating onset of the disease or because of inducement of autoimmune diabetes in children who previously were at lower risk. High levels of immunoglobulin (Ig), specifically, IgM and IgA, and a low level of IgG were reported in adult patients; however no studies have analyzed the increasing incidence in relation to Ig levels. Our aim was to describe Ig in children newly diagnosed with diabetes and in their healthy siblings. Children with T1D expressed significantly lower IgG (p &lt; 0.01) and higher IgA levels (p = 0.045), whereas no differences in IgE or IgM (p &gt; 0.5) levels were found. Age-specific levels were unchanged over a 9-year period. In patients and siblings IgG. IgA and IgE increased by age (p &lt; 0.001); which was in contrast to IgM (p &gt; 0.05). The continued increase in IgG levels by age indicates that adult levels are reached later than in previously studied cohorts, thereby indicating a slower maturation of the immune system. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.}},
  author       = {{Svensson, Jannet and Eising, Stefanie and Mortensen, Henrik Bindesbol and Christiansen, Michael and Laursen, Inga and Lernmark, Åke and Ramelius, Anita and Simonsen, Lars Bjarke and Carstensen, Bendix and Pociot, Flemming and Johannesen, Jesper}},
  issn         = {{0198-8859}},
  keywords     = {{Type 1 diabetes; Immunoglobulin; Incidence; Hygiene}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{17--25}},
  publisher    = {{Elsevier}},
  series       = {{Human Immunology}},
  title        = {{High levels of immunoglobulin E and a continuous increase in immunoglobulin G and immunoglobulin M by age in children with newly diagnosed type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1016/j.humimm.2011.10.019}},
  doi          = {{10.1016/j.humimm.2011.10.019}},
  volume       = {{73}},
  year         = {{2012}},
}