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North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Eussen, Simone J. P. M.; Nilsen, Roy M.; Midttun, Oivind; Hustad, Steinar; IJssennagger, Noortje; Meyer, Klaus; Fredriksen, Ase; Ulvik, Arve; Ueland, Per M. and Brennan, Paul, et al. (2013) In British Journal of Nutrition 110(2). p.363-374
Abstract
Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between... (More)
Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10.4 nmol/l; women, 10.7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north-south gradient. Vitamin B-2 concentrations were highest in Northern Europe (men, 22.2 nmol/l; women, 26.0 nmol/l) and decreased towards Southern Europe (P-trend < 0.001). Vitamin B-6 concentrations were highest in Central Europe in men (77.3 nmol/l) and highest in the North among women (70.4 nmol/l), with decreasing concentrations towards Southern Europe in women (P-trend < 0.001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle. (Less)
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publication status
published
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keywords
B-vitamins, Amino acids, One-carbon metabolism, Europe
in
British Journal of Nutrition
volume
110
issue
2
pages
363 - 374
publisher
Cambridge University Press
external identifiers
  • wos:000320544400018
  • scopus:84879143141
ISSN
1475-2662
DOI
10.1017/S0007114512004990
language
English
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yes
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9e0e21fc-1c88-45f7-bbf2-ae66a66928e9 (old id 3975715)
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2013-09-02 07:35:37
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@article{9e0e21fc-1c88-45f7-bbf2-ae66a66928e9,
  abstract     = {Different lifestyle patterns across Europe may influence plasma concentrations of B-vitamins and one-carbon metabolites and their relation to chronic disease. Comparison of published data on one-carbon metabolites in Western European regions is difficult due to differences in sampling procedures and analytical methods between studies. The present study aimed, to compare plasma concentrations of one-carbon metabolites in Western European regions with one laboratory performing all biochemical analyses. We performed the present study in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort among 5446 presumptively healthy individuals. Quantile regression was used to compare sex-specific median concentrations between Northern (Denmark and Sweden), Central (France, Germany, The Netherlands and United Kingdom) and Southern (Greece, Spain and Italy) European regions. The lowest folate concentrations were observed in Northern Europe (men, 10.4 nmol/l; women, 10.7 nmol/l) and highest concentrations in Central Europe. Cobalamin concentrations were slightly higher in Northern Europe (men, 330 pmol/l; women, 352 pmol/l) compared with Central and Southern Europe, but did not show a clear north-south gradient. Vitamin B-2 concentrations were highest in Northern Europe (men, 22.2 nmol/l; women, 26.0 nmol/l) and decreased towards Southern Europe (P-trend &lt; 0.001). Vitamin B-6 concentrations were highest in Central Europe in men (77.3 nmol/l) and highest in the North among women (70.4 nmol/l), with decreasing concentrations towards Southern Europe in women (P-trend &lt; 0.001). In men, concentrations of serine, glycine and sarcosine increased from the north to south. In women, sarcosine increased from Northern to Southern Europe. These findings may provide relevant information for the study of regional differences of chronic disease incidence in association with lifestyle.},
  author       = {Eussen, Simone J. P. M. and Nilsen, Roy M. and Midttun, Oivind and Hustad, Steinar and IJssennagger, Noortje and Meyer, Klaus and Fredriksen, Ase and Ulvik, Arve and Ueland, Per M. and Brennan, Paul and Johansson, Mattias and Bueno-de-Mesquita, Bas and Vineis, Paolo and Chuang, Shu-Chun and Boutron-Ruault, Marie Christine and Dossus, Laure and Perquier, Florence and Overvad, Kim and Teucher, Birgit and Grote, Verena A. and Trichopoulou, Antonia and Adarakis, George and Plada, Maria and Sieri, Sabina and Tumino, Rosario and Santucci de Magistris, Maria and Ros, Martine M. and Peeters, Petra H. M. and Luisa Redondo, Maria and Zamora-Ros, Raul and Chirlaque, Maria-Dolores and Ardanaz, Eva and Sonestedt, Emily and Ericson, Ulrika and Schneede, Joern and van Guelpen, Bethany and Wark, Petra A. and Gallo, Valentina and Norat, Teresa and Riboli, Elio and Vollset, Stein Emil},
  issn         = {1475-2662},
  keyword      = {B-vitamins,Amino acids,One-carbon metabolism,Europe},
  language     = {eng},
  number       = {2},
  pages        = {363--374},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {North-south gradients in plasma concentrations of B-vitamins and other components of one-carbon metabolism in Western Europe: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study},
  url          = {http://dx.doi.org/10.1017/S0007114512004990},
  volume       = {110},
  year         = {2013},
}